Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731
Huang, Qi, Cai, Dawei, Yan, Ran, Li, Lichun, Zong, Yuhua, Guo, Lida, Mercier, Alexandre, Zhou, Yi, Tang, Ariel, Henne, Kirk, Colonno, Richard
Published in Antimicrobial agents and chemotherapy (20.10.2020)
Published in Antimicrobial agents and chemotherapy (20.10.2020)
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A comprehensive listing of bioactivation pathways of organic functional groups
Kalgutkar, Amit S, Gardner, Iain, Obach, R Scott, Shaffer, Christopher L, Callegari, Ernesto, Henne, Kirk R, Mutlib, Abdul E, Dalvie, Deepak K, Lee, Jae S, Nakai, Yasuhiro, O'Donnell, John P, Boer, Jason, Harriman, Shawn P
Published in Current drug metabolism (01.06.2005)
Published in Current drug metabolism (01.06.2005)
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Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme
Arguello, Annie, Mahon, Cathal S, Calvert, Meredith E K, Chan, Darren, Dugas, Jason C, Pizzo, Michelle E, Thomsen, Elliot R, Chau, Roni, Damo, Lorna A, Duque, Joseph, Fang, Meng, Giese, Tina, Kim, Do Jin, Liang, Nicholas, Nguyen, Hoang N, Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Ullman, Julie C, Wang, Junhua, Dennis, Mark S, Diaz, Dolores, Gunasekaran, Kannan, Henne, Kirk R, Lewcock, Joseph W, Sanchez, Pascal E, Troyer, Matthew D, Harris, Jeffrey M, Scearce-Levie, Kimberly, Shan, Lu, Watts, Ryan J, Thorne, Robert G, Henry, Anastasia G, Kariolis, Mihalis S
Published in The Journal of experimental medicine (07.03.2022)
Published in The Journal of experimental medicine (07.03.2022)
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Journal Article
Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease
Cushing, Timothy D., Hao, Xiaolin, Shin, Youngsook, Andrews, Kristin, Brown, Matthew, Cardozo, Mario, Chen, Yi, Duquette, Jason, Fisher, Ben, Gonzalez-Lopez de Turiso, Felix, He, Xiao, Henne, Kirk R., Hu, Yi-Ling, Hungate, Randall, Johnson, Michael G., Kelly, Ron C., Lucas, Brian, McCarter, John D., McGee, Lawrence R., Medina, Julio C., San Miguel, Tisha, Mohn, Deanna, Pattaropong, Vatee, Pettus, Liping H., Reichelt, Andreas, Rzasa, Robert M., Seganish, Jennifer, Tasker, Andrew S., Wahl, Robert C., Wannberg, Sharon, Whittington, Douglas A., Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Dawei, Metz, Daniela P.
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II
Wang, Junhua, Bhalla, Akhil, Ullman, Julie C, Fang, Meng, Ravi, Ritesh, Arguello, Annie, Thomsen, Elliot, Tsogtbaatar, Buyankhishig, Guo, Jing L, Skuja, Lukas L, Dugas, Jason C, Davis, Sonnet S, Poda, Suresh B, Gunasekaran, Kannan, Costanzo, Simona, Sweeney, Zachary K, Henry, Anastasia G, Harris, Jeffrey M, Henne, Kirk R, Astarita, Giuseppe
Published in International journal of molecular sciences (30.07.2020)
Published in International journal of molecular sciences (30.07.2020)
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Journal Article
Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement
Henne, Kirk R, Ason, Brandon, Howard, Monique, Wang, Wei, Sun, Jeonghoon, Higbee, Jared, Tang, Jie, Matsuda, Katherine C, Xu, Ren, Zhou, Lei, Chan, Joyce C Y, King, Chadwick, Piper, Derek E, Ketchem, Randal R, Michaels, Mark Leo, Jackson, Simon M, Retter, Marc W
Published in The Journal of pharmacology and experimental therapeutics (01.04.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2015)
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Journal Article
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Kariolis, Mihalis S, Wells, Robert C, Getz, Jennifer A, Kwan, Wanda, Mahon, Cathal S, Tong, Raymond, Kim, Do Jin, Srivastava, Ankita, Bedard, Catherine, Henne, Kirk R, Giese, Tina, Assimon, Victoria A, Chen, Xiaocheng, Zhang, Yin, Solanoy, Hilda, Jenkins, Katherine, Sanchez, Pascal E, Kane, Lesley, Miyamoto, Takashi, Chew, Kylie S, Pizzo, Michelle E, Liang, Nicholas, Calvert, Meredith E K, DeVos, Sarah L, Baskaran, Sulochanadevi, Hall, Sejal, Sweeney, Zachary K, Thorne, Robert G, Watts, Ryan J, Dennis, Mark S, Silverman, Adam P, Zuchero, Y Joy Yu
Published in Science translational medicine (27.05.2020)
Published in Science translational medicine (27.05.2020)
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Journal Article
Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome
Arguello, Annie, Meisner, René, Thomsen, Elliot R, Nguyen, Hoang N, Ravi, Ritesh, Simms, Jeffrey, Lo, Iris, Speckart, Jessica, Holtzman, Julia, Gill, Thomas M, Chan, Darren, Cheng, Yuhsiang, Chiu, Chi-Lu, Dugas, Jason C, Fang, Meng, Lopez, Isabel A, Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Zhu, Yuda, Bhalla, Akhil, Henne, Kirk R, Henry, Anastasia G, Delucchi, Anthony, Costanzo, Simona, Harris, Jeffrey M, Diaz, Dolores, Scearce-Levie, Kimberly, Sanchez, Pascal E
Published in JCI insight (08.10.2021)
Published in JCI insight (08.10.2021)
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Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme
Henne, Kirk R, Tran, Thuy B, VandenBrink, Brooke M, Rock, Dan A, Aidasani, Divesh K, Subramanian, Raju, Mason, Andrew K, Stresser, David M, Teffera, Yohannes, Wong, Simon G, Johnson, Michael G, Chen, Xiaoqi, Tonn, George R, Wong, Bradley K
Published in Drug metabolism and disposition (01.07.2012)
Published in Drug metabolism and disposition (01.07.2012)
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Journal Article
Bioactivation of 4-Ipomeanol by CYP4B1: Adduct Characterization and Evidence for an Enedial Intermediate
Baer, Brian R, Rettie, Allan E, Henne, Kirk R
Published in Chemical research in toxicology (01.05.2005)
Published in Chemical research in toxicology (01.05.2005)
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Journal Article
Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/D-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction
WONG, Simon G, FAN, Peter W, SUBRAMANIAN, Raju, TONN, George R, HENNE, Kirk R, JOHNSON, Michael G, TADANO LOHR, Michelle, WONG, Bradley K
Published in Drug metabolism and disposition (01.05.2010)
Published in Drug metabolism and disposition (01.05.2010)
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Journal Article
Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome
Arguello, Annie, Meisner, René, Thomsen, Elliot R., Nguyen, Hoang N., Ravi, Ritesh, Simms, Jeffrey, Lo, Iris, Speckart, Jessica, Holtzman, Julia, Gill, Thomas M., Chan, Darren, Cheng, Yuhsiang, Chiu, Chi-Lu, Dugas, Jason C., Fang, Meng, Lopez, Isabel A., Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Zhu, Yuda, Bhalla, Akhil, Henne, Kirk R., Henry, Anastasia G., Delucchi, Anthony, Costanzo, Simona, Harris, Jeffrey M., Diaz, Dolores, Scearce-Levie, Kimberly, Sanchez, Pascal E.
Published in JCI insight (08.10.2021)
Published in JCI insight (08.10.2021)
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Journal Article
A comparison of substrate dynamics in human CYP2E1 and CYP2A6
Harrelson, John P., Henne, Kirk R., Alonso, Darwin O.V., Nelson, Sidney D.
Published in Biochemical and biophysical research communications (26.01.2007)
Published in Biochemical and biophysical research communications (26.01.2007)
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Journal Article
BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONE-IMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4
KALGUTKAR, Amit S, VAZ, Alfin D. N, HOP, Cornelis E. C. A, LAME, Mary E, HENNE, Kirk R, SOGLIA, John, ZHAO, Sabrina X, ABRAMOV, Yuri A, LOMBARDO, Franco, COLLIN, Claire, HENDSCH, Zachary S
Published in Drug metabolism and disposition (01.02.2005)
Published in Drug metabolism and disposition (01.02.2005)
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Journal Article
Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4
Kalgutkar, Amit S., Henne, Kirk R., Lame, Mary E., Vaz, Alfin D.N., Collin, Claire, Soglia, John R., Zhao, Sabrina X., Hop, Cornelis E.C.A.
Published in Chemico-biological interactions (30.06.2005)
Published in Chemico-biological interactions (30.06.2005)
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Journal Article
Covalent Linkage of Prosthetic Heme to CYP4 Family P450 Enzymes
Henne, Kirk R, Kunze, Kent L, Zheng, Yi-Min, Christmas, Peter, Soberman, Roy J, Rettie, Allan E
Published in Biochemistry (Easton) (30.10.2001)
Published in Biochemistry (Easton) (30.10.2001)
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Journal Article
Covalent Heme Binding to CYP4B1 via Glu310 and a Carbocation Porphyrin Intermediate
Zheng, Yi-Min, Baer, Brian R, Kneller, M. Byron, Henne, Kirk R, Kunze, Kent L, Rettie, Allan E
Published in Biochemistry (Easton) (22.04.2003)
Published in Biochemistry (Easton) (22.04.2003)
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Journal Article
Enzymatic Determinants of the Substrate Specificity of CYP2C9: Role of B‘−C Loop Residues in Providing the π-Stacking Anchor Site for Warfarin Binding
Haining, Robert L, Jones, Jeffrey P, Henne, Kirk R, Fisher, Michael B, Koop, Dennis R, Trager, William F, Rettie, Allan E
Published in Biochemistry (Easton) (16.03.1999)
Published in Biochemistry (Easton) (16.03.1999)
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Journal Article
Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis
Zheng, Y.i-Min, Henne, Kirk R., Charmley, Patrick, Kim, Richard B., McCarver, D.Gail, Cabacungan, Erwin T., Hines, Ronald N., Rettie, Allan E.
Published in Toxicology and applied pharmacology (15.01.2003)
Published in Toxicology and applied pharmacology (15.01.2003)
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Journal Article
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation
Liao, Fan, Li, Aimin, Xiong, Monica, Bien-Ly, Nga, Jiang, Hong, Zhang, Yin, Finn, Mary Beth, Hoyle, Rosa, Keyser, Jennifer, Lefton, Katheryn B, Robinson, Grace O, Serrano, Javier Remolina, Silverman, Adam P, Guo, Jing L, Getz, Jennifer, Henne, Kirk, Leyns, Cheryl Eg, Gallardo, Gilbert, Ulrich, Jason D, Sullivan, Patrick M, Lerner, Eli Paul, Hudry, Eloise, Sweeney, Zachary K, Dennis, Mark S, Hyman, Bradley T, Watts, Ryan J, Holtzman, David M
Published in The Journal of clinical investigation (01.05.2018)
Published in The Journal of clinical investigation (01.05.2018)
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