613 HER2-XPAT, a novel protease-activatable prodrug T cell engager (TCE), with potent T-cell activation and efficacy in solid tumors and large predicted safety margins in non-human primate (NHP)
Cattaruzza, Fiore, Nazeer, Ayesha, Lange, Zachary, Koski, Caitlin, Hammond, Mikhail, Dao-Pick, Trang, Henkensiefken, Angela, Derynck, Mika, Schellenberger, Volker, Irving, Bryan
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Abstract 3376: HER2-XPAT and EGFR-XPAT: Pro-drug T-cell engagers (TCEs) engineered to address o n -target, o ff -tumor toxicity with potent efficacy in vitro and in vivo and large safety margins in NHP
Cattaruzza, Fiore, Nazeer, Ayesha, Lange, Zachary, Hammond, Mikhail, Koski, Caitlin, Henkensiefken, Angela, Derynck, Mika K., Irving, Bryan, Schellenberger, Volker
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract PS17-11: Her2-xpat, a novel protease-activatable prodrug t-cell engager (tce), exhibits potent t-cell activation and efficacy in her2 tumors, yielding large predicted safety margins based on non-human primate (nhp)
Cattaruzza, Fiore, Nazeer, Ayesha, Lange, Zachary, Koski, Caitlin, Hammond, Mikhail, Henkensiefken, Angela, Dao-Pick, Trang, Derynck, Mika K, Irving, Bryan, Schellenberger, Volker
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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활성화 가능한 치료제와 관련된 조성물 및 방법
RENNERFELDT DEENA, HENKENSIEFKEN ANGELA, SCHELLENBERGER VOLKER, TO MILTON
Year of Publication 25.04.2023
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Year of Publication 25.04.2023
Patent
시토카인 접합체
YOUNG TRACY, IRVING BRYAN, HENKENSIEFKEN ANGELA, JOHANSEN ERIC, CHAUHAN VIBHA, SCHELLENBERGER VOLKER, YEUNG VALENTINE
Year of Publication 27.03.2023
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Year of Publication 27.03.2023
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Precision-activated T-cell engagers targeting HER2 or EGFR and CD3 mitigate on-target, off-tumor toxicity for immunotherapy in solid tumors
Cattaruzza, Fiore, Nazeer, Ayesha, To, Milton, Hammond, Mikhail, Koski, Caitlin, Liu, Lucas Y, Pete Yeung, V, Rennerfeldt, Deena A, Henkensiefken, Angela, Fox, Michael, Lam, Sharon, Morrissey, Kari M, Lange, Zachary, Podust, Vladimir N, Derynck, Mika K, Irving, Bryan A, Schellenberger, Volker
Published in Nature cancer (01.04.2023)
Published in Nature cancer (01.04.2023)
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HER-2 표적화 이중특이적 조성물 및 이의 제조 및 사용 방법
FOX MICHAEL, DERYNCK MIKA, MACCANN DARRAGH, MCCLORY JAMES, IRVING BRYAN, HENKENSIEFKEN ANGELA, JOHANSEN ERIC, KUHN PHILLIPP, FRENZEL ANDRE, SCHELLENBERGER VOLKER, TO MILTON
Year of Publication 24.03.2023
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Year of Publication 24.03.2023
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COMPOSITIONS AND METHODS RELATED TO ACTIVATABLE THERAPEUTIC AGENTS
RENNERFELDT, Deena, HENKENSIEFKEN, Angela, SCHELLENBERGER, Volker, TO, Milton
Year of Publication 12.10.2023
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Year of Publication 12.10.2023
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COMPOSITIONS AND METHODS RELATED TO ACTIVATABLE THERAPEUTIC AGENTS
RENNERFELDT, Deena, HENKENSIEFKEN, Angela, SCHELLENBERGER, Volker, TO, Milton
Year of Publication 31.05.2023
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Year of Publication 31.05.2023
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Compositions and methods related to activatable therapeutic agents
RENNERFELDT, Deena, HENKENSIEFKEN, Angela, SCHELLENBERGER, Volker, TO, Milton
Year of Publication 16.03.2023
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Year of Publication 16.03.2023
Patent
CYTOKINE CONJUGATES
CHAUHAN, Vibha, JOHANSEN, Eric, HENKENSIEFKEN, Angela, SCHELLENBERGER, Volker, YEUNG, Valentine, IRVING, Bryan, YOUNG, Tracy
Year of Publication 31.07.2024
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Year of Publication 31.07.2024
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COMPOSITIONS AND METHODS RELATED TO ACTIVATABLE THERAPEUTIC AGENTS
RENNERFELDT, Deena, HENKENSIEFKEN, Angela, SCHELLENBERGER, Volker, TO, Milton
Year of Publication 27.01.2022
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Year of Publication 27.01.2022
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COMPOSITIONS AND METHODS RELATED TO ACTIVATABLE THERAPEUTIC AGENTS
SCHELLENBERGER, VOLKER, RENNERFELDT, DEENA, TO, MILTON, HENKENSIEFKEN, ANGELA
Year of Publication 27.01.2022
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Year of Publication 27.01.2022
Patent
CYTOKINE CONJUGATES
CHAUHAN, Vibha, JOHANSEN, Eric, HENKENSIEFKEN, Angela, SCHELLENBERGER, Volker, YEUNG, Valentine, IRVING, Bryan, YOUNG, Tracy
Year of Publication 24.08.2023
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Year of Publication 24.08.2023
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