Structural determinants driving homoserine lactone ligand selection in the Pseudomonas aeruginosa LasR quorum-sensing receptor
McCready, Amelia R., Paczkowski, Jon E., Henke, Brad R., Bassler, Bonnie L.
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2019)
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Flavonoids Suppress Pseudomonas aeruginosa Virulence through Allosteric Inhibition of Quorum-sensing Receptors
Paczkowski, Jon E., Mukherjee, Sampriti, McCready, Amelia R., Cong, Jian-Ping, Aquino, Christopher J., Kim, Hahn, Henke, Brad R., Smith, Chari D., Bassler, Bonnie L.
Published in The Journal of biological chemistry (10.03.2017)
Published in The Journal of biological chemistry (10.03.2017)
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Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk
Feaver, Ryan E, Bowers, M. Scott, Cole, Banumathi K, Hoang, Steve, Lawson, Mark J, Taylor, Justin, LaMoreaux, Brian D, Zhao, Lin, Henke, Brad R, Johns, Brian A, Nyborg, Andrew C, Wamhoff, Brian R, Figler, Robert A
Published in PloS one (08.09.2023)
Published in PloS one (08.09.2023)
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Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein–Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production
Taylor, Isabelle R, Paczkowski, Jon E, Jeffrey, Philip D, Henke, Brad R, Smith, Chari D, Bassler, Bonnie L
Published in ACS chemical biology (16.04.2021)
Published in ACS chemical biology (16.04.2021)
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Mechanism underlying autoinducer recognition in the Vibrio cholerae DPO-VqmA quorum-sensing pathway
Huang, Xiuliang, Duddy, Olivia P., Silpe, Justin E., Paczkowski, Jon E., Cong, Jianping, Henke, Brad R., Bassler, Bonnie L.
Published in The Journal of biological chemistry (06.03.2020)
Published in The Journal of biological chemistry (06.03.2020)
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Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors
Haffner, Curt D, Becherer, J. David, Boros, Eric E, Cadilla, Rodolfo, Carpenter, Tiffany, Cowan, David, Deaton, David N, Guo, Yu, Harrington, Wallace, Henke, Brad R, Jeune, Michael R, Kaldor, Istvan, Milliken, Naphtali, Petrov, Kim G, Preugschat, Frank, Schulte, Christie, Shearer, Barry G, Shearer, Todd, Smalley, Terrence L, Stewart, Eugene L, Stuart, J. Darren, Ulrich, John C
Published in Journal of medicinal chemistry (23.04.2015)
Published in Journal of medicinal chemistry (23.04.2015)
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Discovery of PqsE Thioesterase Inhibitors for Pseudomonas aeruginosa Using DNA-Encoded Small Molecule Library Screening
Valastyan, Julie S, Tota, Michael R, Taylor, Isabelle R, Stergioula, Vasiliki, Hone, Graham A. B, Smith, Chari D, Henke, Brad R, Carson, Kenneth G, Bassler, Bonnie L
Published in ACS chemical biology (21.02.2020)
Published in ACS chemical biology (21.02.2020)
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Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia
Armstrong, Allison J, Henke, Brad R, Collado, Maria Sol, Taylor, Justin M, Pourtaheri, Taylor D, Dillberger, John E, Roper, Thomas D, Wamhoff, Brian R, Olson, Matthew W, Figler, Robert A, Hoang, Stephen A, Reardon, John E, Johns, Brian A
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor
Paczkowski, Jon E, McCready, Amelia R, Cong, Jian-Ping, Li, Zhijie, Jeffrey, Philip D, Smith, Chari D, Henke, Brad R, Hughson, Frederick M, Bassler, Bonnie L
Published in ACS chemical biology (15.03.2019)
Published in ACS chemical biology (15.03.2019)
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A novel small molecule approach for the treatment of propionic and methylmalonic acidemias
Armstrong, Allison J., Collado, Maria Sol, Henke, Brad R., Olson, Matthew W., Hoang, Stephen A., Hamilton, Christin A., Pourtaheri, Taylor D., Chapman, Kimberly A., Summar, Marshall M., Johns, Brian A., Wamhoff, Brian R., Reardon, John E., Figler, Robert A.
Published in Molecular genetics and metabolism (01.05.2021)
Published in Molecular genetics and metabolism (01.05.2021)
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The PPARs: From Orphan Receptors to Drug Discovery
Willson, Timothy M, Brown, Peter J, Sternbach, Daniel D, Henke, Brad R
Published in Journal of medicinal chemistry (24.02.2000)
Published in Journal of medicinal chemistry (24.02.2000)
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2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships
Deaton, David N., Haffner, Curt D., Henke, Brad R., Jeune, Michael R., Shearer, Barry G., Stewart, Eugene L., Stuart, J. Darren, Ulrich, John C.
Published in Bioorganic & medicinal chemistry (01.05.2018)
Published in Bioorganic & medicinal chemistry (01.05.2018)
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Discovery of Novel Small Molecules that Activate Satellite Cell Proliferation and Enhance Repair of Damaged Muscle
Billin, Andrew N, Bantscheff, Marcus, Drewes, Gerard, Ghidelli-Disse, Sonja, Holt, Jason A, Kramer, Henning F, McDougal, Alan J, Smalley, Terry L, Wells, Carrow I, Zuercher, William J, Henke, Brad R
Published in ACS chemical biology (19.02.2016)
Published in ACS chemical biology (19.02.2016)
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Molecular Basis for Benzodiazepine Agonist Action at the Type 1 Cholecystokinin Receptor
Harikumar, Kaleeckal G., Cawston, Erin E., Lam, Polo C.H., Patil, Achyut, Orry, Andrew, Henke, Brad R., Abagyan, Ruben, Christopoulos, Arthur, Sexton, Patrick M., Miller, Laurence J.
Published in The Journal of biological chemistry (19.07.2013)
Published in The Journal of biological chemistry (19.07.2013)
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A New Series of Estrogen Receptor Modulators That Display Selectivity for Estrogen Receptor β
Henke, Brad R, Consler, Thomas G, Go, Ning, Hale, Ron L, Hohman, Dana R, Jones, Stacey A, Lu, Amy T, Moore, Linda B, Moore, John T, Orband-Miller, Lisa A, Robinett, R. Graham, Shearin, Jean, Spearing, Paul K, Stewart, Eugene L, Turnbull, Philip S, Weaver, Susan L, Williams, Shawn P, Wisely, G. Bruce, Lambert, Millard H
Published in Journal of medicinal chemistry (05.12.2002)
Published in Journal of medicinal chemistry (05.12.2002)
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Journal Article
N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 3. Structure−Activity Relationship and Optimization of the N-Aryl Substituent
Cobb, Jeff E, Blanchard, Steven G, Boswell, Evan G, Brown, Kathleen K, Charifson, Paul S, Cooper, Joel P, Collins, Jon L, Dezube, Milana, Henke, Brad R, Hull-Ryde, Emily A, Lake, Debra H, Lenhard, James M, Oliver, William, Oplinger, Jeffery, Pentti, Mila, Parks, Derek J, Plunket, Kelli D, Tong, Wei-Qin
Published in Journal of medicinal chemistry (03.12.1998)
Published in Journal of medicinal chemistry (03.12.1998)
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N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 2. Structure−Activity Relationship and Optimization of the Phenyl Alkyl Ether Moiety
Collins, Jon L, Blanchard, Steven G, Boswell, G. Evan, Charifson, Paul S, Cobb, Jeff E, Henke, Brad R, Hull-Ryde, Emily A, Kazmierski, Wieslaw M, Lake, Debra H, Leesnitzer, Lisa M, Lehmann, Jürgen, Lenhard, James M, Orband-Miller, Lisa A, Gray-Nunez, Yolanda, Parks, Derek J, Plunkett, Kelli D, Tong, Wei-Qin
Published in Journal of medicinal chemistry (03.12.1998)
Published in Journal of medicinal chemistry (03.12.1998)
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