A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress
Bruno, Peter M, Liu, Yunpeng, Park, Ga Young, Murai, Junko, Koch, Catherine E, Eisen, Timothy J, Pritchard, Justin R, Pommier, Yves, Lippard, Stephen J, Hemann, Michael T
Published in Nature medicine (01.04.2017)
Published in Nature medicine (01.04.2017)
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Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?
Yamanaka, Kinrin, Chatterjee, Nimrat, Hemann, Michael T, Walker, Graham C
Published in PLoS genetics (01.08.2017)
Published in PLoS genetics (01.08.2017)
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The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning
Bruno, Peter M., Lu, Mengrou, Dennis, Kady A., Inam, Haider, Moore, Connor J., Sheehe, John, Elledge, Stephen J., Hemann, Michael T., Pritchard, Justin R.
Published in Proceedings of the National Academy of Sciences - PNAS (25.02.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (25.02.2020)
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Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma
Braun, Christian J., Stanciu, Monica, Boutz, Paul L., Patterson, Jesse C., Calligaris, David, Higuchi, Fumi, Neupane, Rachit, Fenoglio, Silvia, Cahill, Daniel P., Wakimoto, Hiroaki, Agar, Nathalie Y.R., Yaffe, Michael B., Sharp, Phillip A., Hemann, Michael T., Lees, Jacqueline A.
Published in Cancer cell (09.10.2017)
Published in Cancer cell (09.10.2017)
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Sensitizing Protective Tumor Microenvironments to Antibody-Mediated Therapy
Pallasch, Christian P., Leskov, Ilya, Braun, Christian J., Vorholt, Daniela, Drake, Adam, Soto-Feliciano, Yadira M., Bent, Eric H., Schwamb, Janine, Iliopoulou, Bettina, Kutsch, Nadine, van Rooijen, Nico, Frenzel, Lukas P., Wendtner, Clemens M., Heukamp, Lukas, Kreuzer, Karl Anton, Hallek, Michael, Chen, Jianzhu, Hemann, Michael T.
Published in Cell (30.01.2014)
Published in Cell (30.01.2014)
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Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution
Zhao, Boyang, Sedlak, Joseph C., Srinivas, Raja, Creixell, Pau, Pritchard, Justin R., Tidor, Bruce, Lauffenburger, Douglas A., Hemann, Michael T.
Published in Cell (24.03.2016)
Published in Cell (24.03.2016)
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Error-prone translesion synthesis mediates acquired chemoresistance
Xie, Kun, Doles, Jason, Hemann, Michael T., Walker, Graham C., Lehmann, Alan R.
Published in Proceedings of the National Academy of Sciences - PNAS (30.11.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (30.11.2010)
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Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation
Braun, Christian J., Bruno, Peter M., Horlbeck, Max A., Gilbert, Luke A., Weissman, Jonathan S., Hemann, Michael T.
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (05.07.2016)
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Stage-specific sensitivity to p53 restoration during lung cancer progression
Jacks, Tyler, Feldser, David M, Kostova, Kamena K, Winslow, Monte M, Taylor, Sarah E, Cashman, Chris, Whittaker, Charles A, Sanchez-Rivera, Francisco J, Resnick, Rebecca, Bronson, Roderick, Hemann, Michael T
Published in Nature (London) (25.11.2010)
Published in Nature (London) (25.11.2010)
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Integrated regulatory models for inference of subtype‐specific susceptibilities in glioblastoma
Liu, Yunpeng, Shi, Ning, Regev, Aviv, He, Shan, Hemann, Michael T
Published in Molecular systems biology (01.09.2020)
Published in Molecular systems biology (01.09.2020)
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Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer
Qi, Ruogu, Wang, Yongheng, Bruno, Peter M, Xiao, Haihua, Yu, Yingjie, Li, Ting, Lauffer, Sam, Wei, Wei, Chen, Qixian, Kang, Xiang, Song, Haiqin, Yang, Xi, Huang, Xing, Detappe, Alexandre, Matulonis, Ursula, Pepin, David, Hemann, Michael T, Birrer, Michael J, Ghoroghchian, P Peter
Published in Nature communications (18.12.2017)
Published in Nature communications (18.12.2017)
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REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks
Chatterjee, Nimrat, Whitman, Matthew A., Harris, Cynthia A., Min, Sophia M., Jonas, Oliver, Lien, Evan C., Luengo, Alba, Vander Heiden, Matthew G., Hong, Jiyong, Zhou, Pei, Hemann, Michael T., Walker, Graham C.
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2020)
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Journal Article
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
Fenouille, Nina, Bassil, Christopher F, Ben-Sahra, Issam, Benajiba, Lina, Alexe, Gabriela, Ramos, Azucena, Pikman, Yana, Conway, Amy S, Burgess, Michael R, Li, Qing, Luciano, Frédéric, Auberger, Patrick, Galinsky, Ilene, DeAngelo, Daniel J, Stone, Richard M, Zhang, Yi, Perkins, Archibald S, Shannon, Kevin, Hemann, Michael T, Puissant, Alexandre, Stegmaier, Kimberly
Published in Nature medicine (01.03.2017)
Published in Nature medicine (01.03.2017)
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Simultaneous screening of overexpressed genes in breast cancer for oncogenic drivers and tumor dependencies
Mofunanya, Adaobi, Cameron, Eleanor R, Braun, Christian J, Celeste, Frank, Zhao, Xiaoyu, Hemann, Michael T, Scott, Kenneth L, Li, Jinyu, Powers, Scott
Published in Scientific reports (09.06.2024)
Published in Scientific reports (09.06.2024)
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