Mechanisms underlying mutational signatures in human cancers
Helleday, Thomas, Eshtad, Saeed, Nik-Zainal, Serena
Published in Nature reviews. Genetics (01.09.2014)
Published in Nature reviews. Genetics (01.09.2014)
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Journal Article
Chk1 promotes replication fork progression by controlling replication initiation
Petermann, Eva, Woodcock, Mick, Helleday, Thomas
Published in Proceedings of the National Academy of Sciences - PNAS (14.09.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (14.09.2010)
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Journal Article
Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
Petermann, Eva, Orta, Manuel Luís, Issaeva, Natalia, Schultz, Niklas, Helleday, Thomas
Published in Molecular cell (26.02.2010)
Published in Molecular cell (26.02.2010)
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Journal Article
Drugging DNA repair
Jackson, Stephen P., Helleday, Thomas
Published in Science (American Association for the Advancement of Science) (03.06.2016)
Published in Science (American Association for the Advancement of Science) (03.06.2016)
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Journal Article
Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1
SONGMIN YING, HAMDY, Freddie C, HELLEDAY, Thomas
Published in Cancer research (Chicago, Ill.) (01.06.2012)
Published in Cancer research (Chicago, Ill.) (01.06.2012)
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Journal Article
DNA repair pathways as targets for cancer therapy
Helleday, Thomas, Petermann, Eva, Lundin, Cecilia, Hodgson, Ben, Sharma, Ricky A
Published in Nature reviews. Cancer (01.03.2008)
Published in Nature reviews. Cancer (01.03.2008)
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Journal Article
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
Berglund, Emelie, Maaskola, Jonas, Schultz, Niklas, Friedrich, Stefanie, Marklund, Maja, Bergenstråhle, Joseph, Tarish, Firas, Tanoglidi, Anna, Vickovic, Sanja, Larsson, Ludvig, Salmén, Fredrik, Ogris, Christoph, Wallenborg, Karolina, Lagergren, Jens, Ståhl, Patrik, Sonnhammer, Erik, Helleday, Thomas, Lundeberg, Joakim
Published in Nature communications (20.06.2018)
Published in Nature communications (20.06.2018)
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Journal Article
Targeting DNA repair, DNA metabolism and replication stress as anti‐cancer strategies
Puigvert, Jordi Carreras, Sanjiv, Kumar, Helleday, Thomas
Published in The FEBS journal (01.01.2016)
Published in The FEBS journal (01.01.2016)
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Journal Article
Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer
Thålin, Charlotte, Lundström, Staffan, Seignez, Cedric, Daleskog, Maud, Lundström, Annika, Henriksson, Peter, Helleday, Thomas, Phillipson, Mia, Wallén, Håkan, Demers, Mélanie
Published in PloS one (11.01.2018)
Published in PloS one (11.01.2018)
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Journal Article
Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells
Costantino, Lorenzo, Sotiriou, Sotirios K., Rantala, Juha K., Magin, Simon, Mladenov, Emil, Helleday, Thomas, Haber, James E., Iliakis, George, Kallioniemi, Olli P., Halazonetis, Thanos D.
Published in Science (American Association for the Advancement of Science) (03.01.2014)
Published in Science (American Association for the Advancement of Science) (03.01.2014)
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Journal Article
UV stalled replication forks restart by re-priming in human fibroblasts
Elvers, Ingegerd, Johansson, Fredrik, Groth, Petra, Erixon, Klaus, Helleday, Thomas
Published in Nucleic acids research (01.09.2011)
Published in Nucleic acids research (01.09.2011)
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Journal Article
Targeting homologous recombination repair defects in cancer
Evers, Bastiaan, Helleday, Thomas, Jonkers, Jos
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2010)
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2010)
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Journal Article
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
Bryant, Helen E, Petermann, Eva, Schultz, Niklas, Jemth, Ann-Sofie, Loseva, Olga, Issaeva, Natalia, Johansson, Fredrik, Fernandez, Serena, McGlynn, Peter, Helleday, Thomas
Published in The EMBO journal (02.09.2009)
Published in The EMBO journal (02.09.2009)
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Journal Article
Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs
Scaletti, Emma, Jemth, Ann‐Sofie, Helleday, Thomas, Stenmark, Pål
Published in FEBS letters (01.07.2019)
Published in FEBS letters (01.07.2019)
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Journal Article
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
Visnes, Torkild, Cázares-Körner, Armando, Hao, Wenjing, Wallner, Olov, Masuyer, Geoffrey, Loseva, Olga, Mortusewicz, Oliver, Wiita, Elisée, Sarno, Antonio, Manoilov, Aleksandr, Astorga-Wells, Juan, Jemth, Ann-Sofie, Pan, Lang, Sanjiv, Kumar, Karsten, Stella, Gokturk, Camilla, Grube, Maurice, Homan, Evert J, Hanna, Bishoy M F, Paulin, Cynthia B J, Pham, Therese, Rasti, Azita, Berglund, Ulrika Warpman, von Nicolai, Catharina, Benitez-Buelga, Carlos, Koolmeister, Tobias, Ivanic, Dag, Iliev, Petar, Scobie, Martin, Krokan, Hans E, Baranczewski, Pawel, Artursson, Per, Altun, Mikael, Jensen, Annika Jenmalm, Kalderén, Christina, Ba, Xueqing, Zubarev, Roman A, Stenmark, Pål, Boldogh, Istvan, Helleday, Thomas
Published in Science (American Association for the Advancement of Science) (16.11.2018)
Published in Science (American Association for the Advancement of Science) (16.11.2018)
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Journal Article