Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway
Shen, Jianyu, Guillén Mancina, Emilio, Chen, Shenyu, Manolakou, Theodora, Gad, Helge, Warpman Berglund, Ulrika, Sanjiv, Kumar, Helleday, Thomas
Published in Oncogenesis (New York, NY) (25.05.2024)
Published in Oncogenesis (New York, NY) (25.05.2024)
Get full text
Journal Article
Pharmacological OGG1 inhibition decreases murine allergic airway inflammation
Tanner, Lloyd, Bergwik, Jesper, Bhongir, Ravi K. V., Pan, Lang, Dong, Caijuan, Wallner, Olov, Kalderén, Christina, Helleday, Thomas, Boldogh, Istvan, Adner, Mikael, Egesten, Arne
Published in Frontiers in pharmacology (17.10.2022)
Published in Frontiers in pharmacology (17.10.2022)
Get full text
Journal Article
A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown
HIGGINS, Geoff S, PREVO, Remko, LEE, Yin-Fai, HELLEDAY, Thomas, MUSCHEL, Ruth J, TAYLOR, Steve, YOSHIMURA, Michio, HICKSON, Ian D, BERNHARD, Eric J, MCKENNA, W. Gillies
Published in Cancer research (Chicago, Ill.) (01.04.2010)
Published in Cancer research (Chicago, Ill.) (01.04.2010)
Get full text
Journal Article
Crystal structure of human MTH1 and the 8-oxo-dGMP product complex
Svensson, Linda M., Jemth, Ann-Sofie, Desroses, Matthieu, Loseva, Olga, Helleday, Thomas, Högbom, Martin, Stenmark, Pål
Published in FEBS letters (19.08.2011)
Published in FEBS letters (19.08.2011)
Get full text
Journal Article
Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion
Sokolova, Maria, Turunen, Mikko, Mortusewicz, Oliver, Kivioja, Teemu, Herr, Patrick, Vähärautio, Anna, Björklund, Mikael, Taipale, Minna, Helleday, Thomas, Taipale, Jussi
Published in Cell cycle (Georgetown, Tex.) (17.01.2017)
Published in Cell cycle (Georgetown, Tex.) (17.01.2017)
Get full text
Journal Article
OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions
Hanna, Bishoy M F, Helleday, Thomas, Mortusewicz, Oliver
Published in Biomolecules (Basel, Switzerland) (26.10.2020)
Published in Biomolecules (Basel, Switzerland) (26.10.2020)
Get full text
Journal Article
Transcription-Associated Recombination Is Dependent on Replication in Mammalian Cells
Gottipati, Ponnari, Cassel, Tobias N., Savolainen, Linda, Helleday, Thomas
Published in Molecular and Cellular Biology (01.01.2008)
Published in Molecular and Cellular Biology (01.01.2008)
Get full text
Journal Article
Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids
Pettke, Aleksandra, Tampere, Marianna, Pronk, Robin, Wallner, Olov, Falk, Anna, Warpman Berglund, Ulrika, Helleday, Thomas, Mirazimi, Ali, Puumalainen, Marjo-Riitta
Published in Viruses (01.01.2021)
Published in Viruses (01.01.2021)
Get full text
Journal Article
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
Köpper, Frederik, Bierwirth, Cathrin, Schön, Margarete, Kunze, Meike, Elvers, Ingegerd, Kranz, Dominique, Saini, Priyanka, Menon, Manoj B., Walter, David, Sørensen, Claus Storgaard, Gaestel, Matthias, Helleday, Thomas, Schön, Michael P., Dobbelstein, Matthias
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2013)
Get full text
Journal Article
Poly(ADP-ribose) Polymerase (PARP-1) in Homologous Recombination and as a Target for Cancer Therapy
Helleday, Thomas, Bryant, Helen E., Schultz, Niklas
Published in Cell cycle (Georgetown, Tex.) (01.09.2005)
Published in Cell cycle (Georgetown, Tex.) (01.09.2005)
Get full text
Journal Article
A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma
Einarsdottir, Berglind O., Karlsson, Joakim, Söderberg, Elin M. V., Lindberg, Mattias F., Funck-Brentano, Elisa, Jespersen, Henrik, Brynjolfsson, Siggeir F., Olofsson Bagge, Roger, Carstam, Louise, Scobie, Martin, Koolmeister, Tobias, Wallner, Olof, Stierner, Ulrika, Berglund, Ulrika Warpman, Ny, Lars, Nilsson, Lisa M., Larsson, Erik, Helleday, Thomas, Nilsson, Jonas A.
Published in Cell death & disease (24.07.2018)
Published in Cell death & disease (24.07.2018)
Get full text
Journal Article
An Approach for Systems-Level Understanding of Prostate Cancer from High-Throughput Data Integration to Pathway Modeling and Simulation
Mobashir, Mohammad, Turunen, S Pauliina, Izhari, Mohammad Asrar, Ashankyty, Ibraheem Mohammed, Helleday, Thomas, Lehti, Kaisa
Published in Cells (Basel, Switzerland) (01.12.2022)
Published in Cells (Basel, Switzerland) (01.12.2022)
Get full text
Journal Article
STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions
Desroses, Matthieu, Busker, Sander, Astorga-Wells, Juan, Attarha, Sanaz, Kolosenko, Iryna, Zubarev, Roman A., Helleday, Thomas, Grandér, Dan, Page, Brent D.G.
Published in Journal of pharmaceutical and biomedical analysis (25.10.2018)
Published in Journal of pharmaceutical and biomedical analysis (25.10.2018)
Get full text
Journal Article
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses
Tampere, Marianna, Pettke, Aleksandra, Salata, Cristiano, Wallner, Olov, Koolmeister, Tobias, Cazares-Körner, Armando, Visnes, Torkild, Hesselman, Maria Carmen, Kunold, Elena, Wiita, Elisee, Kalderén, Christina, Lightowler, Molly, Jemth, Ann-Sofie, Lehtiö, Janne, Rosenquist, Åsa, Warpman-Berglund, Ulrika, Helleday, Thomas, Mirazimi, Ali, Jafari, Rozbeh, Puumalainen, Marjo-Riitta
Published in Viruses (10.12.2020)
Published in Viruses (10.12.2020)
Get full text
Journal Article
Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma
Oksvold, Morten P., Berglund, Ulrika Warpman, Gad, Helge, Bai, Baoyan, Stokke, Trond, Rein, Idun Dale, Pham, Therese, Sanjiv, Kumar, Øy, Geir Frode, Norum, Jens Henrik, Smeland, Erlend B., Myklebust, June H., Helleday, Thomas, Våtsveen, Thea Kristin
Published in Scientific reports (18.03.2021)
Published in Scientific reports (18.03.2021)
Get full text
Journal Article
MetaCNV - a consensus approach to infer accurate copy numbers from low coverage data
Friedrich, Stefanie, Barbulescu, Remus, Helleday, Thomas, Sonnhammer, Erik L L
Published in BMC medical genomics (01.06.2020)
Published in BMC medical genomics (01.06.2020)
Get full text
Journal Article
OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells
Baquero, Juan Miguel, Marchena-Perea, Erik, Mirabet, Rocío, Torres-Ruiz, Raúl, Blanco-Aparicio, Carmen, Rodríguez-Perales, Sandra, Helleday, Thomas, Benítez-Buelga, Carlos, Benítez, Javier, Osorio, Ana
Published in Frontiers in oncology (10.05.2022)
Published in Frontiers in oncology (10.05.2022)
Get full text
Journal Article
Identification of novel small molecules that inhibit STAT3-dependent transcription and function
Kolosenko, Iryna, Yu, Yasmin, Busker, Sander, Dyczynski, Matheus, Liu, Jianping, Haraldsson, Martin, Palm Apergi, Caroline, Helleday, Thomas, Tamm, Katja Pokrovskaja, Page, Brent D G, Grander, Dan
Published in PloS one (21.06.2017)
Published in PloS one (21.06.2017)
Get full text
Journal Article