Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer's disease
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Published in Molecular neurodegeneration (22.01.2019)
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Structure–Activity Studies of Diazabicyclo[3.3.0]octane-Substituted Pyrazines and Pyridines as Potent α4β2 Nicotinic Acetylcholine Receptor Ligands
Scanio, Marc J. C, Shi, Lei, Bunnelle, William H, Anderson, David J, Helfrich, Rosalind J, Malysz, John, Thorin-Hagene, Kirsten K, Van Handel, Ceclia E, Marsh, Kennan C, Lee, Chih-Hung, Gopalakrishnan, Murali
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease
STOLL, Vincent, WENYING QIN, KEMPF, Dale, SHAM, Hing L, NORBECK, Daniel W, STEWART, Kent D, JAKOB, Clarissa, CHANG PARK, WALTER, K, SIMMER, R. L, HELFRICH, Rosalind, BUSSIERE, Dirk, KAO, J
Published in Bioorganic & medicinal chemistry (01.08.2002)
Published in Bioorganic & medicinal chemistry (01.08.2002)
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Comparative pharmacology of human dopamine D2-like receptor stable cell lines coupled to calcium flux through Gαqo5
MORELAND, Robert B, NAKANE, Masaki, EL-KOUHEN, Odile F, MASTERS, Jeffrey N, BRIONI, Jorge D, DONNELLY-ROBERTS, Diana L, MILLER, Loan N, CHANG, Renjie, UCHIC, Marie E, TERRANOVA, Marc A, GUBBINS, Earl J, HELFRICH, Rosalind J, NAMOVIC, Marian T
Published in Biochemical pharmacology (15.08.2004)
Published in Biochemical pharmacology (15.08.2004)
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A cell-based microarrayed compound screening format for identifying agonists of G-protein-coupled receptors
Gopalakrishnan, Sujatha M., Moreland, Robert B., Kofron, James.L., Helfrich, Rosalind J., Gubbins, Earl, McGowen, Jennifer, Masters, Jeffrey N., Donnelly-Roberts, Diana, Brioni, Jorge D., Burns, David.J., Warrior, Usha
Published in Analytical biochemistry (15.10.2003)
Published in Analytical biochemistry (15.10.2003)
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In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107
Malysz, John, Anderson, David J., Grønlien, Jens H., Ji, Jianguo, Bunnelle, William H., Håkerud, Monika, Thorin-Hagene, Kirten, Ween, Hilde, Helfrich, Rosalind, Hu, Min, Gubbins, Earl, Gopalakrishnan, Sujatha, Puttfarcken, Pamela S., Briggs, Clark A., Li, Jinhe, Meyer, Michael D., Dyhring, Tino, Ahring, Philip K., Nielsen, Elsebet Ø., Peters, Dan, Timmermann, Daniel B., Gopalakrishnan, Murali
Published in The Journal of pharmacology and experimental therapeutics (01.09.2010)
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Abstract 3199: Miniaturized, multiplexed, highly sensitive protein NanoArray assay for measuring biomarkers in dried blood spot (DBS) samples
Dixon, Douglas B., Ivanov, Ivan D., Gubbins, Earl J., Harris, Richard R., Coen, Michael L., Helfrich, Rosalind, Jamil, Haris
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Structure-Activity Studies of Diazabicyclo[3.3.0]octane-Substituted Pyrazines and Pyridines as Potent alpha 4 beta 2 Nicotinic Acetylcholine Receptor Ligands
Scanio, Marc J. C., Shi, Lei, Bunnelle, William H., Anderson, David J., Helfrich, Rosalind J., Malysz, John, Thorin-Hagene, Kirsten K., Van Handel, Ceclia E., Marsh, Kennan C., Lee, Chih-Hung, Gopalakrishnant, Murali
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties
Tietje, Karin R., Anderson, David J., Bitner, R. Scott, Blomme, Eric A., Brackemeyer, Paul J., Briggs, Clark A., Browman, Kaitlin E., Bury, Dagmar, Curzon, Peter, Drescher, Karla U., Frost, Jennifer M., Fryer, Ryan M., Fox, Gerard B., Gronlien, Jens Halvard, Håkerud, Monika, Gubbins, Earl J., Halm, Sabine, Harris, Richard, Helfrich, Rosalind J., Kohlhaas, Kathy L., Law, Devalina, Malysz, John, Marsh, Kennan C., Martin, Ruth L., Meyer, Michael D., Molesky, Angela L., Nikkel, Arthur L., Otte, Stephani, Pan, Liping, Puttfarcken, Pamela S., Radek, Richard J., Robb, Holly M., Spies, Eva, Thorin-Hagene, Kirsten, Waring, Jeffrey F., Ween, Hilde, Xu, Hongyu, Gopalakrishnan, Murali, Bunnelle, William H.
Published in CNS neuroscience & therapeutics (01.03.2008)
Published in CNS neuroscience & therapeutics (01.03.2008)
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Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties
Tietje, Karin R., Anderson, David J., Bitner, R. Scott, Blomme, Eric A., Brackemeyer, Paul J., Briggs, Clark A., Browman, Kaitlin E., Bury, Dagmar, Curzon, Peter, Drescher, Karla U., Frost, Jennifer M., Fryer, Ryan M., Fox, Gerard B., Gronlien, Jens Halvard, Håkerud, Monika, Gubbins, Earl J., Halm, Sabine, Harris, Richard, Helfrich, Rosalind J., Kohlhaas, Kathy L., Law, Devalina, Malysz, John, Marsh, Kennan C., Martin, Ruth L., Meyer, Michael D., Molesky, Angela L., Nikkel, Arthur L., Otte, Stephani, Pan, Liping, Puttfarcken, Pamela S., Radek, Richard J., Robb, Holly M., Spies, Eva, Thorin‐Hagene, Kirsten, Waring, Jeffrey F., Ween, Hilde, Xu, Hongyu, Gopalakrishnan, Murali, Bunnelle, William H.
Published in CNS neuroscience & therapeutics (2008)
Published in CNS neuroscience & therapeutics (2008)
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Syntheses and structure–activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel α7 neuronal nicotinic receptor (NNR) ligands
Li, Tao, Bunnelle, William H., Ryther, Keith B., Anderson, David J., Malysz, John, Helfrich, Rosalind, Grønlien, Jens H., Håkerud, Monika, Peters, Dan, Schrimpf, Michael R., Gopalakrishnan, Murali, Ji, Jianguo
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease
Erickson, J, Neidhart, D J, VanDrie, J, Kempf, D J, Wang, X C, Norbeck, D W, Plattner, J J, Rittenhouse, J W, Turon, M, Wideburg, N
Published in Science (American Association for the Advancement of Science) (03.08.1990)
Published in Science (American Association for the Advancement of Science) (03.08.1990)
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Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5)
Moreland, Robert B, Nakane, Masaki, Donnelly-Roberts, Diana L, Miller, Loan N, Chang, Renjie, Uchic, Marie E, Terranova, Marc A, Gubbins, Earl J, Helfrich, Rosalind J, Namovic, Marian T, El-Kouhen, Odile F, Masters, Jeffrey N, Brioni, Jorge D
Published in Biochemical pharmacology (15.08.2004)
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Published in Biochemical pharmacology (15.08.2004)
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Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands
Li, Tao, Bunnelle, William H, Ryther, Keith B, Anderson, David J, Malysz, John, Helfrich, Rosalind, Grønlien, Jens H, Håkerud, Monika, Peters, Dan, Schrimpf, Michael R, Gopalakrishnan, Murali, Ji, Jianguo
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Journal Article
Comparative pharmacology of human dopamine D 2-like receptor stable cell lines coupled to calcium flux through Gα qo5
Moreland, Robert B, Nakane, Masaki, Donnelly-Roberts, Diana L, Miller, Loan N, Chang, Renjie, Uchic, Marie E, Terranova, Marc A, Gubbins, Earl J, Helfrich, Rosalind J, Namovic, Marian T, El-Kouhen, Odile F, Masters, Jeffrey N, Brioni, Jorge D
Published in Biochemical pharmacology (2004)
Published in Biochemical pharmacology (2004)
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In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107
Malysz, John, Anderson, David J, Grønlien, Jens H, Ji, Jianguo, Bunnelle, William H, Håkerud, Monika, Thorin-Hagene, Kirten, Ween, Hilde, Helfrich, Rosalind, Hu, Min, Gubbins, Earl, Gopalakrishnan, Sujatha, Puttfarcken, Pamela S, Briggs, Clark A, Li, Jinhe, Meyer, Michael D, Dyhring, Tino, Ahring, Philip K, Nielsen, Elsebet Ø, Peters, Dan, Timmermann, Daniel B, Gopalakrishnan, Murali
Published in The Journal of pharmacology and experimental therapeutics (01.09.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2010)
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Journal Article
Preclinical Characterization of A-582941: A Novel alpha 7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties
Tietje, Karin R, Anderson, David J, Bitner, RScott, Blomme, Eric A, Brackemeyer, Paul J, Briggs, Clark A, Browman, Kaitlin E, Bury, Dagmar, Curzon, Peter, Drescher, Karla U, Frost, Jennifer M, Fryer, Ryan M, Fox, Gerard B, Gronlien, Jens Halvard, Haakerud, Monika, Gubbins, Earl J, Halm, Sabine, Harris, Richard, Helfrich, Rosalind J, Kohlhaas, Kathy L, Law, Devalina, Malysz, John, Marsh, Kennan C, Martin, Ruth L, Meyer, Michael D, Molesky, Angela L, Nikkel, Arthur L, Otte, Stephani, Pan, Liping, Puttfarcken, Pamela S, Radek, Richard J, Robb, Holly M, Spies, Eva, Thorin-Hagene, Kirsten, Waring, Jeffrey F, Ween, Hilde, Xu, Hongyu, Gopalakrishnan, Murali, Bunnelle, William H
Published in CNS neuroscience & therapeutics (01.03.2008)
Published in CNS neuroscience & therapeutics (01.03.2008)
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Journal Article
Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
Tietje, Karin R, Anderson, David J, Bitner, R Scott, Blomme, Eric A, Brackemeyer, Paul J, Briggs, Clark A, Browman, Kaitlin E, Bury, Dagmar, Curzon, Peter, Drescher, Karla U, Frost, Jennifer M, Fryer, Ryan M, Fox, Gerard B, Gronlien, Jens Halvard, Håkerud, Monika, Gubbins, Earl J, Halm, Sabine, Harris, Richard, Helfrich, Rosalind J, Kohlhaas, Kathy L, Law, Devalina, Malysz, John, Marsh, Kennan C, Martin, Ruth L, Meyer, Michael D, Molesky, Angela L, Nikkel, Arthur L, Otte, Stephani, Pan, Liping, Puttfarcken, Pamela S, Radek, Richard J, Robb, Holly M, Spies, Eva, Thorin-Hagene, Kirsten, Waring, Jeffrey F, Ween, Hilde, Xu, Hongyu, Gopalakrishnan, Murali, Bunnelle, William H
Published in CNS neuroscience & therapeutics (2008)
Published in CNS neuroscience & therapeutics (2008)
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Journal Article
Preclinical Characterization of A-582941 : A Novel a7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties
TIETJE, Karin R, ANDERSON, David J, FROST, Jennifer M, FRYER, Ryan M, FOX, Gerard B, HALVARD GRONLIEN, Jens, HAKERUD, Monika, GUBBINS, Earl J, HALM, Sabine, HARRIS, Richard, HELFRICH, Rosalind J, KOHLHAAS, Kathy L, BITNER, R. Scott, LAW, Devalina, MALYSZ, John, MARSH, Kennan C, MARTIN, Ruth L, MEYER, Michael D, MOLESKY, Angela L, NIKKEL, Arthur L, OTTE, Stephani, PAN, Liping, PUTTFARCKEN, Pamela S, BLOMME, Eric A, RADEK, Richard J, ROBB, Holly M, SPIES, Eva, THORIN-HAGENE, Kirsten, WARING, Jeffrey F, WEEN, Hilde, HONGYU XU, GOPALAKRISHNAN, Murali, BUNNELLE, William H, BRACKEMEYER, Paul J, BRIGGS, Clark A, BROWMAN, Kaitlin E, BURY, Dagmar, CURZON, Peter, DRESCHER, Karla U
Published in CNS neuroscience & therapeutics (2008)
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Published in CNS neuroscience & therapeutics (2008)
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Cloning and Expression of the Adenosine Kinase Gene from Rat and Human Tissues
McNally, Teresa, Helfrich, Rosalind J., Cowart, Marlon, Dorwin, Sarah A., Meuth, Joseph L., Idler, Kenneth B., Klute, Kimberly A., Simmer, Robert L., Kowaluk, Elizabeth A., Halbert, Donald N.
Published in Biochemical and biophysical research communications (24.02.1997)
Published in Biochemical and biophysical research communications (24.02.1997)
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