Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2
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Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2012)
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Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum
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Published in PLoS pathogens (01.12.2019)
Published in PLoS pathogens (01.12.2019)
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Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation
Nagy, Zoltán Attila, Héja, Dávid, Bencze, Dániel, Kiss, Bence, Boros, Eszter, Szakács, Dávid, Fodor, Krisztián, Wilmanns, Matthias, Kocsis, Andrea, Dobó, József, Gál, Péter, Harmat, Veronika, Pál, Gábor
Published in The Journal of biological chemistry (01.06.2022)
Published in The Journal of biological chemistry (01.06.2022)
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Directed Evolution of Canonical Loops and Their Swapping between Unrelated Serine Proteinase Inhibitors Disprove the Interscaffolding Additivity Model
Boros, Eszter, Sebák, Fanni, Héja, Dávid, Szakács, Dávid, Zboray, Katalin, Schlosser, Gitta, Micsonai, András, Kardos, József, Bodor, Andrea, Pál, Gábor
Published in Journal of molecular biology (01.02.2019)
Published in Journal of molecular biology (01.02.2019)
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Overlapping Specificity of Duplicated Human Pancreatic Elastase 3 Isoforms and Archetypal Porcine Elastase 1 Provides Clues to Evolution of Digestive Enzymes
Boros, Eszter, Szabó, András, Zboray, Katalin, Héja, Dávid, Pál, Gábor, Sahin-Tóth, Miklós
Published in The Journal of biological chemistry (17.02.2017)
Published in The Journal of biological chemistry (17.02.2017)
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Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2
Héja, Dávid, Harmat, Veronika, Fodor, Krisztián, Wilmanns, Matthias, Dobó, József, Kékesi, Katalin A., Závodszky, Péter, Gál, Péter, Pál, Gábor
Published in The Journal of biological chemistry (08.06.2012)
Published in The Journal of biological chemistry (08.06.2012)
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Quantitative Characterization of the Activation Steps of Mannan-binding Lectin (MBL)-associated Serine Proteases (MASPs) Points to the Central Role of MASP-1 in the Initiation of the Complement Lectin Pathway
Megyeri, Márton, Harmat, Veronika, Major, Balázs, Végh, Ádám, Balczer, Júlia, Héja, Dávid, Szilágyi, Katalin, Datz, Dániel, Pál, Gábor, Závodszky, Péter, Gál, Péter, Dobó, József
Published in The Journal of biological chemistry (29.03.2013)
Published in The Journal of biological chemistry (29.03.2013)
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High Affinity Small Protein Inhibitors of Human Chymotrypsin C (CTRC) Selected by Phage Display Reveal Unusual Preference for P4′ Acidic Residues
Szabó, András, Héja, Dávid, Szakács, Dávid, Zboray, Katalin, Kékesi, Katalin A., Radisky, Evette S., Sahin-Tóth, Miklós, Pál, Gábor
Published in The Journal of biological chemistry (24.06.2011)
Published in The Journal of biological chemistry (24.06.2011)
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Dynamic regulation of B cell complement signaling is integral to germinal center responses
Cumpelik, Arun, Heja, David, Hu, Yuan, Varano, Gabriele, Ordikhani, Farideh, Roberto, Mark P., He, Zhengxiang, Homann, Dirk, Lira, Sergio A., Dominguez-Sola, David, Heeger, Peter S.
Published in Nature immunology (01.06.2021)
Published in Nature immunology (01.06.2021)
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Design and testing of a humanized porcine donor for xenotransplantation
Anand, Ranjith P., Layer, Jacob V., Heja, David, Hirose, Takayuki, Lassiter, Grace, Firl, Daniel J., Paragas, Violette B., Akkad, Adam, Chhangawala, Sagar, Colvin, Robert B., Ernst, Russell J., Esch, Nicholas, Getchell, Kristen, Griffin, Alexandra K., Guo, Xiaoyun, Hall, Katherine C., Hamilton, Paula, Kalekar, Lokesh A., Kan, Yinan, Karadagi, Ahmad, Li, Feng, Low, Susan C., Matheson, Rudy, Nehring, Claudia, Otsuka, Ryo, Pandelakis, Matthew, Policastro, Robert A., Pols, Rebecca, Queiroz, Luis, Rosales, Ivy A., Serkin, William T., Stiede, Kathryn, Tomosugi, Toshihide, Xue, Yongqiang, Zentner, Gabriel E., Angeles-Albores, David, Chris Chao, J., Crabtree, Juliet N., Harken, Sierra, Hinkle, Nicole, Lemos, Tania, Li, Mailin, Pantano, Lorena, Stevens, Denise, Subedar, Omar D., Tan, Xiaoqing, Yin, Shiyi, Anwar, Imran J., Aufhauser, David, Capuano, Saverio, Kaufman, Dixon B., Knechtle, Stuart J., Kwun, Jean, Shanmuganayagam, Dhanansayan, Markmann, James F., Church, George M., Curtis, Mike, Kawai, Tatsuo, Youd, Michele E., Qin, Wenning
Published in Nature (London) (12.10.2023)
Published in Nature (London) (12.10.2023)
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Mannan binding lectin modulates alloreactive T cell immunity
Heja, David, Zhao, Dongchang, Ferrara, James, Heeger, Peter
Published in Molecular immunology (01.10.2018)
Published in Molecular immunology (01.10.2018)
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Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation
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Published in Immunity (Cambridge, Mass.) (08.03.2022)
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Year of Publication 26.12.2023
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Year of Publication 24.10.2024
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CELLS, TISSUES, ORGANS, AND ANIMALS HAVING ONE OR MORE MODIFIED GENES FOR ENHANCED XENOGRAFT SURVIVAL AND TOLERANCE
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CELLS, TISSUES, ORGANS, AND ANIMALS HAVING ONE OR MORE MODIFIED GENES FOR ENHANCED XENOGRAFT SURVIVAL AND TOLERANCE
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Year of Publication 14.03.2024
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Cells, tissues, organs and animals having one or more modified genes for enhanced xenograft survival and tolerance
Juliet Crabtree, Michele Youd, Yinan Kan, Violette Paragas, Jacob Layer, David Angeles Albores, Wenning Qin, Ranjith Anand, David Heja, Russell Ernst, Paola Perrat
Year of Publication 01.11.2023
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Year of Publication 01.11.2023
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CELLS, TISSUES, ORGANS, AND ANIMALS HAVING ONE OR MORE MODIFIED GENES FOR ENHANCED XENOGRAFT SURVIVAL AND TOLERANCE
ANAND, Ranjith, PERRAT, Paola, PARAGAS, Violette, QIN, Wenning, KAN, Yinan, HEJA, David, ERNST, Russell, YOUD, Michele, ANGELES ALBORES, David, LAYER, Jacob, CRABTREE, Juliet
Year of Publication 20.09.2023
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Year of Publication 20.09.2023
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CELLS, TISSUES, ORGANS, AND ANIMALS HAVING ONE OR MORE MODIFIED GENES FOR ENHANCED XENOGRAFT SURVIVAL AND TOLERANCE
ANAND, Ranjith, PERRAT, Paola, PARAGAS, Violette, QIN, Wenning, KAN, Yinan, HEJA, David, ERNST, Russell, YOUD, Michele, ANGELES ALBORES, David, LAYER, Jacob, CRABTREE, Juliet
Year of Publication 15.06.2023
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Year of Publication 15.06.2023
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