Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy
JHA, Jay C, GRAY, Stephen P, TOUYZ, Rhian M, COOPER, Mark E, SCHMIDT, Harald H. H. W, JANDELEIT-DAHM, Karin A, BARIT, David, OKABE, Jun, EL-OSTA, Assam, NAMIKOSHI, Tamehachi, THALLAS-BONKE, Vicki, WINGLER, Kirstin, SZYNDRALEWIEZ, Cedric, HERTZ, Freddy
Published in Journal of the American Society of Nephrology (01.06.2014)
Published in Journal of the American Society of Nephrology (01.06.2014)
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NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis
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Published in Circulation (New York, N.Y.) (07.05.2013)
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First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
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Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
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Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes
Sedeek, Mona, Gutsol, Alex, Montezano, Augusto C, Burger, Dylan, Nguyen Dinh Cat, Aurelie, Kennedy, Chris R J, Burns, Kevin D, Cooper, Mark E, Jandeleit-Dahm, Karin, Page, Patrick, Szyndralewiez, Cedric, Heitz, Freddy, Hebert, Richard L, Touyz, Rhian M
Published in Clinical science (1979) (01.02.2013)
Published in Clinical science (1979) (01.02.2013)
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Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism
Garrido-Urbani, Sarah, Jemelin, Stephane, Deffert, Christine, Carnesecchi, Stéphanie, Basset, Olivier, Szyndralewiez, Cédric, Heitz, Freddy, Page, Patrick, Montet, Xavier, Michalik, Liliane, Arbiser, Jack, Rüegg, Curzio, Krause, Karl Heinz, Imhof, Beat A, Imhof, Beat
Published in PloS one (07.02.2011)
Published in PloS one (07.02.2011)
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Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors
Gaggini, Francesca, Laleu, Benoît, Orchard, Mike, Fioraso-Cartier, Laetitia, Cagnon, Laurène, Houngninou-Molango, Sophie, Gradia, Angelo, Duboux, Guillaume, Merlot, Cédric, Heitz, Freddy, Szyndralewiez, Cédric, Page, Patrick
Published in Bioorganic & medicinal chemistry (01.12.2011)
Published in Bioorganic & medicinal chemistry (01.12.2011)
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siRNA screen identifies QPCT as a druggable target for Huntington's disease
Jimenez-Sanchez, Maria, Lam, Wun, Hannus, Michael, Sönnichsen, Birte, Imarisio, Sara, Fleming, Angeleen, Tarditi, Alessia, Menzies, Fiona, Ed Dami, Teresa, Xu, Catherine, Gonzalez-Couto, Eduardo, Lazzeroni, Giulia, Heitz, Freddy, Diamanti, Daniela, Massai, Luisa, Satagopam, Venkata P, Marconi, Guido, Caramelli, Chiara, Nencini, Arianna, Andreini, Matteo, Sardone, Gian Luca, Caradonna, Nicola P, Porcari, Valentina, Scali, Carla, Schneider, Reinhard, Pollio, Giuseppe, O'Kane, Cahir J, Caricasole, Andrea, Rubinsztein, David C
Published in Nature chemical biology (06.04.2015)
Published in Nature chemical biology (06.04.2015)
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NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors
Ford, Kirsty, Hanley, Christopher J, Mellone, Massimiliano, Szyndralewiez, Cedric, Heitz, Freddy, Wiesel, Philippe, Wood, Oliver, Machado, Maria, Lopez, Maria-Antoinette, Ganesan, Anusha-Preethi, Wang, Chuan, Chakravarthy, Ankur, Fenton, Tim R, King, Emma V, Vijayanand, Pandurangan, Ottensmeier, Christian H, Al-Shamkhani, Aymen, Savelyeva, Natalia, Thomas, Gareth J
Published in Cancer research (Chicago, Ill.) (01.05.2020)
Published in Cancer research (Chicago, Ill.) (01.05.2020)
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Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent
Aoyama, Tomonori, Paik, Yong-Han, Watanabe, Sumio, Laleu, Benoît, Gaggini, Francesca, Fioraso-Cartier, Laetitia, Molango, Sophie, Heitz, Freddy, Merlot, Cédric, Szyndralewiez, Cédric, Page, Patrick, Brenner, David A.
Published in Hepatology (Baltimore, Md.) (01.12.2012)
Published in Hepatology (Baltimore, Md.) (01.12.2012)
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Site-directed mutagenesis of the putative human muscarinic M2 receptor binding site
Heitz, F, Holzwarth, J A, Gies, J P, Pruss, R M, Trumpp-Kallmeyer, S, Hibert, M F, Guenet, C
Published in European journal of pharmacology (10.09.1999)
Published in European journal of pharmacology (10.09.1999)
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NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?
Sorce, Silvia, Stocker, Roland, Seredenina, Tamara, Holmdahl, Rikard, Aguzzi, Adriano, Chio, Adriano, Depaulis, Antoine, Heitz, Freddy, Olofsson, Peter, Olsson, Tomas, Duveau, Venceslas, Sanoudou, Despina, Skosgater, Sara, Vlahou, Antonia, Wasquel, Dominique, Krause, Karl-Heinz, Jaquet, Vincent
Published in Free radical biology & medicine (01.11.2017)
Published in Free radical biology & medicine (01.11.2017)
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siRNA screen identifies QPCT as a druggable target for Huntington's disease
Jimenez-Sanchez, Maria, Lam, Wun, Hannus, Michael, Sönnichsen, Birte, Imarisio, Sara, Fleming, Angeleen, Tarditi, Alessia, Menzies, Fiona, Ed Dami, Teresa, Xu, Catherine, Gonzalez-Couto, Eduardo, Lazzeroni, Giulia, Heitz, Freddy, Diamanti, Daniela, Massai, Luisa, Satagopam, Venkata P, Marconi, Guido, Caramelli, Chiara, Nencini, Arianna, Andreini, Matteo, Sardone, Gian Luca, Caradonna, Nicola P, Porcari, Valentina, Scali, Carla, Schneider, Reinhard, Pollio, Giuseppe, O'Kane, Cahir J, Caricasole, Andrea, Rubinsztein, David C
Published in Nature chemical biology (01.05.2015)
Published in Nature chemical biology (01.05.2015)
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Inhibition of host NOX1 blocks tumor growth and enhances checkpoint inhibitor-based immunotherapy
Stalin, Jimmy, Garrido-Urbani, Sarah, Heitz, Freddy, Szyndralewiez, Cédric, Jemelin, Stephane, Coquoz, Oriana, Ruegg, Curzio, Imhof, Beat A
Published in Life science alliance (01.08.2019)
Published in Life science alliance (01.08.2019)
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NOX 저해제의 암 치료용 용도
HANLEY CHRISTOPHER, FORD KIRSTY, HEITZ FREDDY, THOMAS GARETH, WIESEL PHILIPPE
Year of Publication 02.07.2020
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Year of Publication 02.07.2020
Patent
NADPH 산화효소 저해제로서의 신규한 화합물
MACHIN PETER, CELANIRE SYLVAIN, SHARPE ANDREW, WISHART GRANT, PERRY BENJAMIN, CHAMBERS MARK, HEITZ FREDDY, HODGES ALASTAIR
Year of Publication 11.06.2021
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Year of Publication 11.06.2021
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Small molecule drug discovery for Huntington's Disease
Fecke, Wolfgang, Gianfriddo, Marco, Gaviraghi, Giovanni, Terstappen, Georg C., Heitz, Freddy
Published in Drug discovery today (01.05.2009)
Published in Drug discovery today (01.05.2009)
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A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation
Lazzeroni, Giulia, Benicchi, Tiziana, Heitz, Freddy, Magnoni, Letizia, Diamanti, Daniela, Rossini, Lara, Massai, Luisa, Federico, Cesare, Fecke, Wolfgang, Caricasole, Andrea, La Rosa, Salvatore, Porcari, Valentina
Published in Journal of biomolecular screening (01.10.2013)
Published in Journal of biomolecular screening (01.10.2013)
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Abstract 367: A Nox4 Inhibitor, GKT 137831, Decreases Aldosterone Synthesis, Adiposity and Vascular Contractility in a Murine Model of Diabetes
Montezano, Augusto C, Nguyen Dinh Cat, Aurelie, Antunes, Tayze T, Callera, Glaucia E, Briet, Marie, He, Ying, Page, Patrick, Szyndralewiez, Cedric, Heitz, Freddy, Cooper, Mark E, Touyz, Rhian M
Published in Hypertension (Dallas, Tex. 1979) (01.09.2012)
Published in Hypertension (Dallas, Tex. 1979) (01.09.2012)
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