Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
Gerisch, Michael, Heinig, Roland, Engelen, Anna, Lang, Dieter, Kolkhof, Peter, Radtke, Martin, Platzek, Johannes, Lovis, Kai, Rohde, Gabriele, Schwarz, Thomas
Published in Drug metabolism and disposition (01.11.2018)
Published in Drug metabolism and disposition (01.11.2018)
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Pharmacokinetics of the Novel, Selective, Non-steroidal Mineralocorticoid Receptor Antagonist Finerenone in Healthy Volunteers: Results from an Absolute Bioavailability Study and Drug–Drug Interaction Studies In Vitro and In Vivo
Heinig, Roland, Gerisch, Michael, Engelen, Anna, Nagelschmitz, Johannes, Loewen, Stephanie
Published in European journal of drug metabolism and pharmacokinetics (01.12.2018)
Published in European journal of drug metabolism and pharmacokinetics (01.12.2018)
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Pharmacokinetics, safety and tolerability of the novel, selective mineralocorticoid receptor antagonist finerenone - results from first-in-man and relative bioavailability studies
Lentini, Silvia, Heinig, Roland, Kimmeskamp-Kirschbaum, Nina, Wensing, Georg
Published in Fundamental & clinical pharmacology (01.04.2016)
Published in Fundamental & clinical pharmacology (01.04.2016)
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Abstract 1666: Regorafenib (BAY 73-4506): preclinical pharmacology and clinical identification and quantification of its major metabolites
Zopf, Dieter, Heinig, Roland, Thierauch, Karl-Heinz, Hirth-Dietrich, Claudia, Hafner, Frank-Thorsten, Christensen, Olaf, Lin, Tiffany, Wilhelm, Scott, Radtke, Martin
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Determination of finerenone – a novel, selective, nonsteroidal mineralocorticoid receptor antagonist – in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study in venous and capillary human plasma
Rohde, Gabriele, Loewen, Stephanie, Heinig, Roland
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.05.2021)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.05.2021)
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Results From Phase I Studies Investigating the Dose Linearity of Finerenone Tablets and the Influence of Food or pH-Modifying Comedications on its Pharmacokinetics in Healthy Male Volunteers
Heinig, Roland, Nagelschmitz, Johannes, Loewen, Stephanie
Published in European journal of drug metabolism and pharmacokinetics (01.07.2022)
Published in European journal of drug metabolism and pharmacokinetics (01.07.2022)
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A Phase I Dose―Escalation Study of Regorafenib (BAY 73―4506), an Inhibitor of Oncogenic, Angiogenic, and Stromal Kinases, in Patients with Advanced Solid Tumors
MROSS, Klaus, FROST, Annette, CHRISTENSEN, Olaf, STEINBILD, Simone, HEDBOM, Susanne, BÜCHERT, Martin, FASOL, Ulrike, UNGER, Clemens, KRÄTZSCHMAR, Jörn, HEINIG, Roland, BOIX, Oliver
Published in Clinical cancer research (01.05.2012)
Published in Clinical cancer research (01.05.2012)
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Results From Drug–Drug Interaction Studies In Vitro and In Vivo Investigating the Inhibitory Effect of Finerenone on the Drug Transporters BCRP, OATP1B1, and OATP1B3
Heinig, Roland, Fricke, Robert, Wertz, Sebastian, Nagelschmitz, Johannes, Loewen, Stephanie
Published in European journal of drug metabolism and pharmacokinetics (01.11.2022)
Published in European journal of drug metabolism and pharmacokinetics (01.11.2022)
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Results from Drug–Drug Interaction Studies In Vitro and In Vivo Investigating the Effect of Finerenone on the Pharmacokinetics of Comedications
Heinig, Roland, Gerisch, Michael, Bairlein, Michaela, Nagelschmitz, Johannes, Loewen, Stephanie
Published in European journal of drug metabolism and pharmacokinetics (01.08.2020)
Published in European journal of drug metabolism and pharmacokinetics (01.08.2020)
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Pharmacokinetics of the Novel Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone (BAY 94-8862) in Individuals with Mild or Moderate Hepatic Impairment
Heinig, Roland, Lambelet, Marc, Nagelschmitz, Johannes, Alatrach, Abir, Halabi, Atef
Published in European journal of drug metabolism and pharmacokinetics (01.10.2019)
Published in European journal of drug metabolism and pharmacokinetics (01.10.2019)
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Finerenone Dose-Exposure-Response for the Primary Kidney Outcome in FIDELIO-DKD Phase III: Population Pharmacokinetic and Time-to-Event Analysis
van den Berg, Paul, Ruppert, Martijn, Mesic, Emir, Snelder, Nelleke, Seelmann, Andreas, Heinig, Roland, Joseph, Amer, Garmann, Dirk, Lippert, Joerg, Eissing, Thomas
Published in Clinical pharmacokinetics (01.03.2022)
Published in Clinical pharmacokinetics (01.03.2022)
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Population Pharmacokinetic and Exposure–Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic Kidney Disease
Snelder, Nelleke, Heinig, Roland, Drenth, Henk-Jan, Joseph, Amer, Kolkhof, Peter, Lippert, Jörg, Garmann, Dirk, Ploeger, Bart, Eissing, Thomas
Published in Clinical pharmacokinetics (01.03.2020)
Published in Clinical pharmacokinetics (01.03.2020)
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Front Cover
Eissing, Thomas, Goulooze, Sebastiaan Camiel, van den Berg, Paul, van Noort, Martijn, Ruppert, Martijn, Snelder, Nelleke, Garmann, Dirk, Lippert, Joerg, Heinig, Roland, Brinker, Meike, Heerspink, Hiddo J. L.
Published in Diabetes, obesity & metabolism (01.03.2024)
Published in Diabetes, obesity & metabolism (01.03.2024)
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Pharmacokinetics and pharmacodynamics of finerenone in patients with chronic kidney disease and type 2 diabetes: Insights based on FIGARO‐DKD and FIDELIO‐DKD
Eissing, Thomas, Goulooze, Sebastiaan Camiel, Berg, Paul, Noort, Martijn, Ruppert, Martijn, Snelder, Nelleke, Garmann, Dirk, Lippert, Joerg, Heinig, Roland, Brinker, Meike, Heerspink, Hiddo J. L.
Published in Diabetes, obesity & metabolism (01.03.2024)
Published in Diabetes, obesity & metabolism (01.03.2024)
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Pharmacokinetics of the Novel Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone (BAY 94-8862) in Individuals With Renal Impairment
Heinig, Roland, Kimmeskamp-Kirschbaum, Nina, Halabi, Atef, Lentini, Silvia
Published in Clinical pharmacology in drug development (01.11.2016)
Published in Clinical pharmacology in drug development (01.11.2016)
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