Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis
Ben-Othman, Nouha, Vieira, Andhira, Courtney, Monica, Record, Fabien, Gjernes, Elisabet, Avolio, Fabio, Hadzic, Biljana, Druelle, Noémie, Napolitano, Tiziana, Navarro-Sanz, Sergi, Silvano, Serena, Al-Hasani, Keith, Pfeifer, Anja, Lacas-Gervais, Sandra, Leuckx, Gunter, Marroquí, Laura, Thévenet, Julien, Madsen, Ole Dragsbaek, Eizirik, Decio Laks, Heimberg, Harry, Kerr-Conte, Julie, Pattou, François, Mansouri, Ahmed, Collombat, Patrick
Published in Cell (12.01.2017)
Published in Cell (12.01.2017)
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Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
Huch, Meritxell, Bonfanti, Paola, Boj, Sylvia F, Sato, Toshiro, Loomans, Cindy J M, van de Wetering, Marc, Sojoodi, Mozhdeh, Li, Vivian S W, Schuijers, Jurian, Gracanin, Ana, Ringnalda, Femke, Begthel, Harry, Hamer, Karien, Mulder, Joyce, van Es, Johan H, de Koning, Eelco, Vries, Robert G J, Heimberg, Harry, Clevers, Hans
Published in The EMBO journal (16.10.2013)
Published in The EMBO journal (16.10.2013)
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Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration
Pan, Fong Cheng, Bankaitis, Eric D, Boyer, Daniel, Xu, Xiaobo, Van de Casteele, Mark, Magnuson, Mark A, Heimberg, Harry, Wright, Christopher V E
Published in Development (Cambridge) (15.02.2013)
Published in Development (Cambridge) (15.02.2013)
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The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells
Courtney, Monica, Gjernes, Elisabet, Druelle, Noémie, Ravaud, Christophe, Vieira, Andhira, Ben-Othman, Nouha, Pfeifer, Anja, Avolio, Fabio, Leuckx, Gunter, Lacas-Gervais, Sandra, Burel-Vandenbos, Fanny, Ambrosetti, Damien, Hecksher-Sorensen, Jacob, Ravassard, Philippe, Heimberg, Harry, Mansouri, Ahmed, Collombat, Patrick
Published in PLoS genetics (01.10.2013)
Published in PLoS genetics (01.10.2013)
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Lineage Tracing Evidence for Transdifferentiation of Acinar to Duct Cells and Plasticity of Human Pancreas
Houbracken, Isabelle, de Waele, Evelien, Lardon, Jessy, Ling, Zhidong, Heimberg, Harry, Rooman, Ilse, Bouwens, Luc
Published in Gastroenterology (New York, N.Y. 1943) (01.08.2011)
Published in Gastroenterology (New York, N.Y. 1943) (01.08.2011)
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Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice
Baeyens, Luc, Lemper, Marie, Leuckx, Gunter, De Groef, Sofie, Bonfanti, Paola, Stangé, Geert, Shemer, Ruth, Nord, Christoffer, Scheel, David W, Pan, Fong C, Ahlgren, Ulf, Gu, Guoqiang, Stoffers, Doris A, Dor, Yuval, Ferrer, Jorge, Gradwohl, Gerard, Wright, Christopher V E, Van de Casteele, Mark, German, Michael S, Bouwens, Luc, Heimberg, Harry
Published in Nature biotechnology (01.01.2014)
Published in Nature biotechnology (01.01.2014)
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A Specific CNOT1 Mutation Results in a Novel Syndrome of Pancreatic Agenesis and Holoprosencephaly through Impaired Pancreatic and Neurological Development
De Franco, Elisa, Watson, Rachel A., Weninger, Wolfgang J., Wong, Chi C., Flanagan, Sarah E., Caswell, Richard, Green, Angela, Tudor, Catherine, Lelliott, Christopher J., Geyer, Stefan H., Maurer-Gesek, Barbara, Reissig, Lukas F., Lango Allen, Hana, Caliebe, Almuth, Siebert, Reiner, Holterhus, Paul Martin, Deeb, Asma, Prin, Fabrice, Hilbrands, Robert, Heimberg, Harry, Ellard, Sian, Hattersley, Andrew T., Barroso, Inês
Published in American journal of human genetics (02.05.2019)
Published in American journal of human genetics (02.05.2019)
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Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential
Loomans, Cindy J.M., Williams Giuliani, Nerys, Balak, Jeetindra, Ringnalda, Femke, van Gurp, Léon, Huch, Meritxell, Boj, Sylvia F., Sato, Toshiro, Kester, Lennart, de Sousa Lopes, Susana M. Chuva, Roost, Matthias S., Bonner-Weir, Susan, Engelse, Marten A., Rabelink, Ton J., Heimberg, Harry, Vries, Robert G.J., van Oudenaarden, Alexander, Carlotti, Françoise, Clevers, Hans, de Koning, Eelco J.P.
Published in Stem cell reports (13.03.2018)
Published in Stem cell reports (13.03.2018)
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Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program
van Arensbergen, Joris, García-Hurtado, Javier, Moran, Ignasi, Maestro, Miguel Angel, Xu, Xiaobo, Van de Casteele, Mark, Skoudy, Anouchka L, Palassini, Matteo, Heimberg, Harry, Ferrer, Jorge
Published in Genome research (01.06.2010)
Published in Genome research (01.06.2010)
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Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?
Bourgeois, Stephanie, Sawatani, Toshiaki, Van Mulders, Annelore, De Leu, Nico, Heremans, Yves, Heimberg, Harry, Cnop, Miriam, Staels, Willem
Published in Cells (Basel, Switzerland) (19.01.2021)
Published in Cells (Basel, Switzerland) (19.01.2021)
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Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia
Prévot, Pierre-Paul, Simion, Alexandru, Grimont, Adrien, Colletti, Marta, Khalaileh, Abed, Van den Steen, Géraldine, Sempoux, Christine, Xu, Xiaobo, Roelants, Véronique, Hald, Jacob, Bertrand, Luc, Heimberg, Harry, Konieczny, Stephen F, Dor, Yuval, Lemaigre, Frédéric P, Jacquemin, Patrick
Published in Gut (01.12.2012)
Published in Gut (01.12.2012)
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Ex Vivo Expansion and Differentiation of Human and Mouse Fetal Pancreatic Progenitors Are Modulated by Epidermal Growth Factor
Bonfanti, Paola, Nobecourt, Estelle, Oshima, Masaya, Albagli-Curiel, Olivier, Laurysens, Veerle, Stangé, Geert, Sojoodi, Mozhdeh, Heremans, Yves, Heimberg, Harry, Scharfmann, Raphael
Published in Stem cells and development (01.08.2015)
Published in Stem cells and development (01.08.2015)
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Semi-automated digital measurement as the method of choice for beta cell mass analysis
Coppens, Violette, Leuckx, Gunter, Heremans, Yves, Staels, Willem, Verdonck, Yannick, Baeyens, Luc, De Leu, Nico, Heimberg, Harry
Published in PloS one (06.02.2018)
Published in PloS one (06.02.2018)
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Generation of Functional Beta-Like Cells from Human Exocrine Pancreas
Lima, Maria J, Muir, Kenneth R, Docherty, Hilary M, McGowan, Neil W A, Forbes, Shareen, Heremans, Yves, Heimberg, Harry, Casey, John, Docherty, Kevin
Published in PloS one (31.05.2016)
Published in PloS one (31.05.2016)
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Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas
Gassen, Naomi, Overmeire, Eva, Leuckx, Gunter, Heremans, Yves, Groef, Sofie, Cai, Ying, Elkrim, Yvon, Gysemans, Conny, Stijlemans, Benoît, Casteele, Mark, Baetselier, Patrick, Leu, Nico, Heimberg, Harry, Ginderachter, Jo A.
Published in European journal of immunology (01.05.2015)
Published in European journal of immunology (01.05.2015)
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Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming
Swales, Nathalie, Martens, Geert A, Bonné, Stefan, Heremans, Yves, Borup, Rehannah, Van de Casteele, Mark, Ling, Zhidong, Pipeleers, Daniel, Ravassard, Philippe, Nielsen, Finn, Ferrer, Jorge, Heimberg, Harry
Published in PloS one (14.05.2012)
Published in PloS one (14.05.2012)
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Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation
Cai, Ying, Martens, Geert A., Hinke, Simon A., Heimberg, Harry, Pipeleers, Daniel, Van de Casteele, Mark
Published in Free radical biology & medicine (2007)
Published in Free radical biology & medicine (2007)
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Combining MK626, a novel DPP-4 inhibitor, and low-dose monoclonal CD3 antibody for stable remission of new-onset diabetes in mice
Ding, Lei, Gysemans, Conny A, Stangé, Geert, Heremans, Yves, Yuchi, Yixing, Takiishi, Tatiana, Korf, Hannelie, Chintinne, Marie, Carr, Richard D, Heimberg, Harry, Pipeleers, Daniel, Mathieu, Chantal
Published in PloS one (30.09.2014)
Published in PloS one (30.09.2014)
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Recapitulation of Embryonic Neuroendocrine Differentiation in Adult Human Pancreatic Duct Cells Expressing Neurogenin 3
Heremans, Yves, Van De Casteele, Mark, Peter in't Veld, Gradwohl, Gerard, Serup, Palle, Madsen, Ole, Pipeleers, Daniel, Heimberg, Harry
Published in The Journal of cell biology (28.10.2002)
Published in The Journal of cell biology (28.10.2002)
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