Towards the Total Synthesis of Vibsanin E, 15-O-Methylcyclovibsanin B,3-Hydroxyvibsanin E, Furanovibsanin A, and 3-O-Methylfuranovibsanin A
Schwartz, Brett D., Tilly, David P., Heim, Ralf, Wiedemann, Stefan, Williams, Craig M., Bernhardt, Paul V.
Published in European Journal of Organic Chemistry (01.07.2006)
Published in European Journal of Organic Chemistry (01.07.2006)
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Book Review
Journal Article
Expedient Construction of the Vibsanin E Core without the Use of Protecting Groups
Heim, Ralf, Wiedemann, Stefan, Williams, Craig M, Bernhardt, Paul V
Published in Organic letters (31.03.2005)
Published in Organic letters (31.03.2005)
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Journal Article
Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure−Activity and Structure−Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives
Lucas, Simon, Negri, Matthias, Heim, Ralf, Zimmer, Christina, Hartmann, Rolf W
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Journal Article
1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: A new class of potent and selective aldosterone synthase inhibitors
Grombein, Cornelia M., Hu, Qingzhong, Heim, Ralf, Rau, Sabrina, Zimmer, Christina, Hartmann, Rolf W.
Published in European journal of medicinal chemistry (07.01.2015)
Published in European journal of medicinal chemistry (07.01.2015)
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Journal Article
In Vivo Active Aldosterone Synthase Inhibitors with Improved Selectivity: Lead Optimization Providing a Series of Pyridine Substituted 3,4-Dihydro-1H-quinolin-2-one Derivatives
Lucas, Simon, Heim, Ralf, Ries, Christina, Schewe, Katarzyna E, Birk, Barbara, Hartmann, Rolf W
Published in Journal of medicinal chemistry (25.12.2008)
Published in Journal of medicinal chemistry (25.12.2008)
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Journal Article
Novel Aldosterone Synthase Inhibitors with Extended Carbocyclic Skeleton by a Combined Ligand-Based and Structure-Based Drug Design Approach
Lucas, Simon, Heim, Ralf, Negri, Matthias, Antes, Iris, Ries, Christina, Schewe, Katarzyna E, Bisi, Alessandra, Gobbi, Silvia, Hartmann, Rolf W
Published in Journal of medicinal chemistry (09.10.2008)
Published in Journal of medicinal chemistry (09.10.2008)
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Journal Article
Unexpected results of a SNAr-reaction. A novel synthetic approach to 1-arylthio-2-naphthols
Grombein, Cornelia M., Hu, Qingzhong, Heim, Ralf, Huch, Volker, Hartmann, Rolf W.
Published in Tetrahedron letters (27.11.2013)
Published in Tetrahedron letters (27.11.2013)
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Journal Article
Unexpected results of a S-NAr-reaction. A novel synthetic approach to 1-arylthio-2-naphthols
Grombein, Cornelia M., Hu, Qingzhong, Heim, Ralf, Huch, Volker, Hartmann, Rolf W.
Published in Tetrahedron letters (27.11.2013)
Published in Tetrahedron letters (27.11.2013)
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Journal Article
Overcoming Undesirable CYP1A2 Inhibition of Pyridylnaphthalene-Type Aldosterone Synthase Inhibitors: Influence of Heteroaryl Derivatization on Potency and Selectivity
Heim, Ralf, Lucas, Simon, Grombein, Cornelia M, Ries, Christina, Schewe, Katarzyna E, Negri, Matthias, Birk, Barbara, Hartmann, Rolf W
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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Journal Article
In Vivo Active Aldosterone Synthase Inhibitors with Improved Selectivity: Lead Optimization Providing a Series of Pyridine Substituted 3,4-Dihydro-1 H -quinolin-2-one Derivatives
Lucas, Simon, Heim, Ralf, Ries, Christina, Schewe, Katarzyna E., Birk, Barbara, Hartmann, Rolf W.
Published in Journal of medicinal chemistry (25.12.2008)
Published in Journal of medicinal chemistry (25.12.2008)
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Journal Article