Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
Msaouel, Pavlos, Malouf, Gabriel G., Su, Xiaoping, Yao, Hui, Tripathi, Durga N., Soeung, Melinda, Gao, Jianjun, Rao, Priya, Coarfa, Cristian, Creighton, Chad J., Bertocchio, Jean-Philippe, Kunnimalaiyaan, Selvi, Multani, Asha S., Blando, Jorge, He, Rong, Shapiro, Daniel D., Perelli, Luigi, Srinivasan, Sanjana, Carbone, Federica, Pilié, Patrick G., Karki, Menuka, Seervai, Riyad N.H., Vokshi, Bujamin H., Lopez-Terrada, Dolores, Cheng, Emily H., Tang, Ximing, Lu, Wei, Wistuba, Ignacio I., Thompson, Timothy C., Davidson, Irwin, Giuliani, Virginia, Schlacher, Katharina, Carugo, Alessandro, Heffernan, Timothy P., Sharma, Padmanee, Karam, Jose A., Wood, Christopher G., Walker, Cheryl L., Genovese, Giannicola, Tannir, Nizar M.
Published in Cancer cell (11.05.2020)
Published in Cancer cell (11.05.2020)
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PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy
Hsu, Joanne I., Dayaram, Tajhal, Tovy, Ayala, De Braekeleer, Etienne, Jeong, Mira, Wang, Feng, Zhang, Jianhua, Heffernan, Timothy P., Gera, Sonal, Kovacs, Jeffrey J., Marszalek, Joseph R., Bristow, Christopher, Yan, Yuanqing, Garcia-Manero, Guillermo, Kantarjian, Hagop, Vassiliou, George, Futreal, P. Andrew, Donehower, Lawrence A., Takahashi, Koichi, Goodell, Margaret A.
Published in Cell stem cell (01.11.2018)
Published in Cell stem cell (01.11.2018)
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Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state
Echeverria, Gloria V, Ge, Zhongqi, Seth, Sahil, Zhang, Xiaomei, Jeter-Jones, Sabrina, Zhou, Xinhui, Cai, Shirong, Tu, Yizheng, McCoy, Aaron, Peoples, Michael, Sun, Yuting, Qiu, Huan, Chang, Qing, Bristow, Christopher, Carugo, Alessandro, Shao, Jiansu, Ma, Xiaoyan, Harris, Angela, Mundi, Prabhjot, Lau, Rosanna, Ramamoorthy, Vandhana, Wu, Yun, Alvarez, Mariano J, Califano, Andrea, Moulder, Stacy L, Symmans, William F, Marszalek, Joseph R, Heffernan, Timothy P, Chang, Jeffrey T, Piwnica-Worms, Helen
Published in Science translational medicine (17.04.2019)
Published in Science translational medicine (17.04.2019)
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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Delmore, Jake E., Issa, Ghayas C., Lemieux, Madeleine E., Rahl, Peter B., Shi, Junwei, Jacobs, Hannah M., Kastritis, Efstathios, Gilpatrick, Timothy, Paranal, Ronald M., Qi, Jun, Chesi, Marta, Schinzel, Anna C., McKeown, Michael R., Heffernan, Timothy P., Vakoc, Christopher R., Bergsagel, P. Leif, Ghobrial, Irene M., Richardson, Paul G., Young, Richard A., Hahn, William C., Anderson, Kenneth C., Kung, Andrew L., Bradner, James E., Mitsiades, Constantine S.
Published in Cell (16.09.2011)
Published in Cell (16.09.2011)
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Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis
Del Poggetto, Edoardo, Ho, I-Lin, Balestrieri, Chiara, Yen, Er-Yen, Zhang, Shaojun, Citron, Francesca, Shah, Rutvi, Corti, Denise, Diaferia, Giuseppe R, Li, Chieh-Yuan, Loponte, Sara, Carbone, Federica, Hayakawa, Yoku, Valenti, Giovanni, Jiang, Shan, Sapio, Luigi, Jiang, Hong, Dey, Prasenjit, Gao, Sisi, Deem, Angela K, Rose-John, Stefan, Yao, Wantong, Ying, Haoqiang, Rhim, Andrew D, Genovese, Giannicola, Heffernan, Timothy P, Maitra, Anirban, Wang, Timothy C, Wang, Linghua, Draetta, Giulio F, Carugo, Alessandro, Natoli, Gioacchino, Viale, Andrea
Published in Science (American Association for the Advancement of Science) (17.09.2021)
Published in Science (American Association for the Advancement of Science) (17.09.2021)
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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Viale, Andrea, Pettazzoni, Piergiorgio, Lyssiotis, Costas A, Ying, Haoqiang, Sánchez, Nora, Marchesini, Matteo, Carugo, Alessandro, Green, Tessa, Seth, Sahil, Giuliani, Virginia, Kost-Alimova, Maria, Muller, Florian, Colla, Simona, Nezi, Luigi, Genovese, Giannicola, Deem, Angela K, Kapoor, Avnish, Yao, Wantong, Brunetto, Emanuela, Kang, Ya'an, Yuan, Min, Asara, John M, Wang, Y Alan, Heffernan, Timothy P, Kimmelman, Alec C, Wang, Huamin, Fleming, Jason B, Cantley, Lewis C, DePinho, Ronald A, Draetta, Giulio F
Published in Nature (London) (30.10.2014)
Published in Nature (London) (30.10.2014)
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Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
Cascone, Tina, McKenzie, Jodi A., Mbofung, Rina M., Punt, Simone, Wang, Zhe, Xu, Chunyu, Williams, Leila J., Wang, Zhiqiang, Bristow, Christopher A., Carugo, Alessandro, Peoples, Michael D., Li, Lerong, Karpinets, Tatiana, Huang, Lu, Malu, Shruti, Creasy, Caitlin, Leahey, Sara E., Chen, Jiong, Chen, Yuan, Pelicano, Helen, Bernatchez, Chantale, Gopal, Y.N. Vashisht, Heffernan, Timothy P., Hu, Jianhua, Wang, Jing, Amaria, Rodabe N., Garraway, Levi A., Huang, Peng, Yang, Peiying, Wistuba, Ignacio I., Woodman, Scott E., Roszik, Jason, Davis, R. Eric, Davies, Michael A., Heymach, John V., Hwu, Patrick, Peng, Weiyi
Published in Cell metabolism (01.05.2018)
Published in Cell metabolism (01.05.2018)
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Telomere dysfunction induces metabolic and mitochondrial compromise
SAHIN, Ergün, COLLA, Simona, MASER, Richard S, TONON, Giovanni, FOERSTER, Friedrich, ROBERT XIONG, WANG, Y. Alan, SHUKLA, Sachet A, JASKELIOFF, Mariela, MARTIN, Eric S, HEFFERNAN, Timothy P, PROTOPOPOV, Alexei, LIESA, Marc, IVANOVA, Elena, MAHONEY, John E, KOST-ALIMOVA, Maria, PERRY, Samuel R, BRONSON, Roderick, LIAO, Ronglih, MULLIGAN, Richard, SHIRIHAI, Orian S, CHIN, Lynda, DEPINHO, Ronald A, MOSLEHI, Javid, MÜLLER, Florian L, MIRA GUO, COOPER, Marcus, KOTTON, Darrell, FABIAN, Attila J, WALKEY, Carl
Published in Nature (London) (17.02.2011)
Published in Nature (London) (17.02.2011)
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High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
Echeverria, Gloria V, Powell, Emily, Seth, Sahil, Ge, Zhongqi, Carugo, Alessandro, Bristow, Christopher, Peoples, Michael, Robinson, Frederick, Qiu, Huan, Shao, Jiansu, Jeter-Jones, Sabrina L, Zhang, Xiaomei, Ramamoorthy, Vandhana, Cai, Shirong, Wu, Wenhui, Draetta, Giulio, Moulder, Stacy L, Symmans, William F, Chang, Jeffrey T, Heffernan, Timothy P, Piwnica-Worms, Helen
Published in Nature communications (29.11.2018)
Published in Nature communications (29.11.2018)
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BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition
Hofmann, Marco H, Gmachl, Michael, Ramharter, Juergen, Savarese, Fabio, Gerlach, Daniel, Marszalek, Joseph R, Sanderson, Michael P, Kessler, Dirk, Trapani, Francesca, Arnhof, Heribert, Rumpel, Klaus, Botesteanu, Dana-Adriana, Ettmayer, Peter, Gerstberger, Thomas, Kofink, Christiane, Wunberg, Tobias, Zoephel, Andreas, Fu, Szu-Chin, Teh, Jessica L, Böttcher, Jark, Pototschnig, Nikolai, Schachinger, Franziska, Schipany, Katharina, Lieb, Simone, Vellano, Christopher P, O'Connell, Jonathan C, Mendes, Rachel L, Moll, Jurgen, Petronczki, Mark, Heffernan, Timothy P, Pearson, Mark, McConnell, Darryl B, Kraut, Norbert
Published in Cancer discovery (01.01.2021)
Published in Cancer discovery (01.01.2021)
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The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
Vangamudi, Bhavatarini, Paul, Thomas A, Shah, Parantu K, Kost-Alimova, Maria, Nottebaum, Lisa, Shi, Xi, Zhan, Yanai, Leo, Elisabetta, Mahadeshwar, Harshad S, Protopopov, Alexei, Futreal, Andrew, Tieu, Trang N, Peoples, Mike, Heffernan, Timothy P, Marszalek, Joseph R, Toniatti, Carlo, Petrocchi, Alessia, Verhelle, Dominique, Owen, Dafydd R, Draetta, Giulio, Jones, Philip, Palmer, Wylie S, Sharma, Shikhar, Andersen, Jannik N
Published in Cancer research (Chicago, Ill.) (15.09.2015)
Published in Cancer research (Chicago, Ill.) (15.09.2015)
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Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis
Kim, Michael P, Li, Xinqun, Deng, Jenying, Zhang, Yun, Dai, Bingbing, Allton, Kendra L, Hughes, Tara G, Siangco, Christian, Augustine, Jithesh J, Kang, Ya'an, McDaniel, Joy M, Xiong, Shunbin, Koay, Eugene J, McAllister, Florencia, Bristow, Christopher A, Heffernan, Timothy P, Maitra, Anirban, Liu, Bin, Barton, Michelle C, Wasylishen, Amanda R, Fleming, Jason B, Lozano, Guillermina
Published in Cancer discovery (01.08.2021)
Published in Cancer discovery (01.08.2021)
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Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy
Peng, Weiyi, Chen, Jie Qing, Liu, Chengwen, Malu, Shruti, Creasy, Caitlin, Tetzlaff, Michael T, Xu, Chunyu, McKenzie, Jodi A, Zhang, Chunlei, Liang, Xiaoxuan, Williams, Leila J, Deng, Wanleng, Chen, Guo, Mbofung, Rina, Lazar, Alexander J, Torres-Cabala, Carlos A, Cooper, Zachary A, Chen, Pei-Ling, Tieu, Trang N, Spranger, Stefani, Yu, Xiaoxing, Bernatchez, Chantale, Forget, Marie-Andree, Haymaker, Cara, Amaria, Rodabe, McQuade, Jennifer L, Glitza, Isabella C, Cascone, Tina, Li, Haiyan S, Kwong, Lawrence N, Heffernan, Timothy P, Hu, Jianhua, Bassett, Jr, Roland L, Bosenberg, Marcus W, Woodman, Scott E, Overwijk, Willem W, Lizée, Gregory, Roszik, Jason, Gajewski, Thomas F, Wargo, Jennifer A, Gershenwald, Jeffrey E, Radvanyi, Laszlo, Davies, Michael A, Hwu, Patrick
Published in Cancer discovery (01.02.2016)
Published in Cancer discovery (01.02.2016)
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Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials
Yap, Timothy A, Daver, Naval, Mahendra, Mikhila, Zhang, Jixiang, Kamiya-Matsuoka, Carlos, Meric-Bernstam, Funda, Kantarjian, Hagop M, Ravandi, Farhad, Collins, Meghan E, Francesco, Maria Emilia Di, Dumbrava, Ecaterina E, Fu, Siqing, Gao, Sisi, Gay, Jason P, Gera, Sonal, Han, Jing, Hong, David S, Jabbour, Elias J, Ju, Zhenlin, Karp, Daniel D, Lodi, Alessia, Molina, Jennifer R, Baran, Natalia, Naing, Aung, Ohanian, Maro, Pant, Shubham, Pemmaraju, Naveen, Bose, Prithviraj, Piha-Paul, Sarina A, Rodon, Jordi, Salguero, Carolina, Sasaki, Koji, Singh, Anand K, Subbiah, Vivek, Tsimberidou, Apostolia M, Xu, Quanyun A, Yilmaz, Musa, Zhang, Qi, Li, Yuan, Bristow, Christopher A, Bhattacharjee, Meenakshi B, Tiziani, Stefano, Heffernan, Timothy P, Vellano, Christopher P, Jones, Philip, Heijnen, Cobi J, Kavelaars, Annemieke, Marszalek, Joseph R, Konopleva, Marina
Published in Nature medicine (01.01.2023)
Published in Nature medicine (01.01.2023)
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Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition
Yan, Liang, Tu, Bo, Yao, Jun, Gong, Jing, Carugo, Alessandro, Bristow, Christopher A, Wang, Qiuyun, Zhu, Cihui, Dai, Bingbing, Kang, Ya'an, Han, Leng, Feng, Ningping, Jin, Yanqing, Fleming, Jason, Heffernan, Timothy P, Yao, Wantong, Ying, Haoqiang
Published in Cancer research (Chicago, Ill.) (01.08.2021)
Published in Cancer research (Chicago, Ill.) (01.08.2021)
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Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer
Evans, Kurt W, Yuca, Erkan, Scott, Stephen S, Zhao, Ming, Paez Arango, Natalia, Cruz Pico, Christian X, Saridogan, Turcin, Shariati, Maryam, Class, Caleb A, Bristow, Christopher A, Vellano, Christopher P, Zheng, Xiaofeng, Gonzalez-Angulo, Ana Maria, Su, Xiaoping, Tapia, Coya, Chen, Ken, Akcakanat, Argun, Lim, Bora, Tripathy, Debu, Yap, Timothy A, Francesco, Maria Emilia Di, Draetta, Giulio F, Jones, Philip, Heffernan, Timothy P, Marszalek, Joseph R, Meric-Bernstam, Funda
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Published in Cancer research (Chicago, Ill.) (01.11.2021)
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Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities
Skoulidis, Ferdinandos, Byers, Lauren A, Diao, Lixia, Papadimitrakopoulou, Vassiliki A, Tong, Pan, Izzo, Julie, Behrens, Carmen, Kadara, Humam, Parra, Edwin R, Canales, Jaime Rodriguez, Zhang, Jianjun, Giri, Uma, Gudikote, Jayanthi, Cortez, Maria A, Yang, Chao, Fan, Youhong, Peyton, Michael, Girard, Luc, Coombes, Kevin R, Toniatti, Carlo, Heffernan, Timothy P, Choi, Murim, Frampton, Garrett M, Miller, Vincent, Weinstein, John N, Herbst, Roy S, Wong, Kwok-Kin, Zhang, Jianhua, Sharma, Padmanee, Mills, Gordon B, Hong, Waun K, Minna, John D, Allison, James P, Futreal, Andrew, Wang, Jing, Wistuba, Ignacio I, Heymach, John V
Published in Cancer discovery (01.08.2015)
Published in Cancer discovery (01.08.2015)
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Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer
Yao, Wantong, Rose, Johnathon L, Wang, Wei, Seth, Sahil, Jiang, Hong, Taguchi, Ayumu, Liu, Jintan, Yan, Liang, Kapoor, Avnish, Hou, Pingping, Chen, Ziheng, Wang, Qiuyun, Nezi, Luigi, Xu, Zhaohui, Yao, Jun, Hu, Baoli, Pettazzoni, Piergiorgio F, Ho, I Lin, Feng, Ningping, Ramamoorthy, Vandhana, Jiang, Shan, Deng, Pingna, Ma, Grace J, Den, Peter, Tan, Zhi, Zhang, Shu Xing, Wang, Huamin, Wang, Y Alan, Deem, Angela K, Fleming, Jason B, Carugo, Alessandro, Heffernan, Timothy P, Maitra, Anirban, Viale, Andrea, Ying, Haoqiang, Hanash, Samir, DePinho, Ronald A, Draetta, Giulio F
Published in Nature (London) (01.04.2019)
Published in Nature (London) (01.04.2019)
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KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells
Mahadevan, Krishnan K., McAndrews, Kathleen M., LeBleu, Valerie S., Yang, Sujuan, Lyu, Hengyu, Li, Bingrui, Sockwell, Amari M., Kirtley, Michelle L., Morse, Sami J., Moreno Diaz, Barbara A., Kim, Michael P., Feng, Ningping, Lopez, Anastasia M., Guerrero, Paola A., Paradiso, Francesca, Sugimoto, Hikaru, Arian, Kent A., Ying, Haoqiang, Barekatain, Yasaman, Sthanam, Lakshmi Kavitha, Kelly, Patience J., Maitra, Anirban, Heffernan, Timothy P., Kalluri, Raghu
Published in Cancer cell (11.09.2023)
Published in Cancer cell (11.09.2023)
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