Platelet biology and functions: new concepts and clinical perspectives
van der Meijden, Paola E. J., Heemskerk, Johan W. M.
Published in Nature reviews cardiology (01.03.2019)
Published in Nature reviews cardiology (01.03.2019)
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Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions
Huang, Jingnan, Swieringa, Frauke, Solari, Fiorella A., Provenzale, Isabella, Grassi, Luigi, De Simone, Ilaria, Baaten, Constance C. F. M. J., Cavill, Rachel, Sickmann, Albert, Frontini, Mattia, Heemskerk, Johan W. M.
Published in Scientific reports (11.06.2021)
Published in Scientific reports (11.06.2021)
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Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis
Lievens, Dirk, Zernecke, Alma, Seijkens, Tom, Soehnlein, Oliver, Beckers, Linda, Munnix, Imke C.A., Wijnands, Erwin, Goossens, Pieter, van Kruchten, Roger, Thevissen, Larissa, Boon, Louis, Flavell, Richard A., Noelle, Randolph J., Gerdes, Norbert, Biessen, Erik A., Daemen, Mat J.A.P., Heemskerk, Johan W.M., Weber, Christian, Lutgens, Esther
Published in Blood (18.11.2010)
Published in Blood (18.11.2010)
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Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner
Westein, Erik, van der Meer, Andries D., Kuijpers, Marijke J. E., Frimat, Jean-Philippe, van den Berg, Albert, Heemskerk, Johan W. M.
Published in Proceedings of the National Academy of Sciences - PNAS (22.01.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (22.01.2013)
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An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts
Tantiwong, Chukiat, Dunster, Joanne L., Cavill, Rachel, Tomlinson, Michael G., Wierling, Christoph, Heemskerk, Johan W. M., Gibbins, Jonathan M.
Published in Scientific reports (08.03.2023)
Published in Scientific reports (08.03.2023)
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Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets
Zhang, Pengyu, Solari, Fiorella A, Heemskerk, Johan W M, Kuijpers, Marijke J E, Sickmann, Albert, Walter, Ulrich, Jurk, Kerstin
Published in International journal of molecular sciences (24.04.2023)
Published in International journal of molecular sciences (24.04.2023)
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Journal Article
Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan
Provenzale, Isabella, De Simone, Ilaria, Gibbins, Jonathan M, Heemskerk, Johan W. M, van der Meijden, Paola E. J, Jones, Chris I
Published in International journal of molecular sciences (01.09.2023)
Published in International journal of molecular sciences (01.09.2023)
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Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics
Fernández, Delia I., Troitiño, Sara, Sobota, Vladimír, Tullemans, Bibian M. E., Zou, Jinmi, van den Hurk, Helma, García, Ángel, Honarnejad, Saman, Kuijpers, Marijke J. E., Heemskerk, Johan W. M.
Published in Scientific reports (14.03.2024)
Published in Scientific reports (14.03.2024)
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Journal Article
Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype
Vajen, Tanja, Benedikter, Birke J., Heinzmann, Alexandra C. A., Vasina, Elena M., Henskens, Yvonne, Parsons, Martin, Maguire, Patricia B., Stassen, Frank R., Heemskerk, Johan W. M., Schurgers, Leon J., Koenen, Rory R.
Published in Journal of extracellular vesicles (01.12.2017)
Published in Journal of extracellular vesicles (01.12.2017)
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Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome
van Geffen, Johanna P., Swieringa, Frauke, van Kuijk, Kim, Tullemans, Bibian M. E., Solari, Fiorella A., Peng, Bing, Clemetson, Kenneth J., Farndale, Richard W., Dubois, Ludwig J., Sickmann, Albert, Zahedi, René P., Ahrends, Robert, Biessen, Erik A. L., Sluimer, Judith C., Heemskerk, Johan W. M., Kuijpers, Marijke J. E.
Published in Scientific reports (08.12.2020)
Published in Scientific reports (08.12.2020)
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Journal Article
Platelet response heterogeneity in thrombus formation
Munnix, Imke C A, Cosemans, Judith M E M, Auger, Jocelyn M, Heemskerk, Johan W M
Published in Thrombosis and haemostasis (01.12.2009)
Published in Thrombosis and haemostasis (01.12.2009)
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New fundamentals in hemostasis
Versteeg, Henri H, Heemskerk, Johan W M, Levi, Marcel, Reitsma, Pieter H
Published in Physiological reviews (01.01.2013)
Published in Physiological reviews (01.01.2013)
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Journal Article
Platelet activation and blood coagulation
Heemskerk, Johan W M, Bevers, Edouard M, Lindhout, Theo
Published in Thrombosis and haemostasis (01.08.2002)
Published in Thrombosis and haemostasis (01.08.2002)
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Quantitative and qualitative changes in platelet traits of sunitinib-treated patients with renal cell carcinoma in relation to circulating sunitinib levels: a proof-of-concept study
Tullemans, Bibian M E, Brouns, Sanne L N, Swieringa, Frauke, Sabrkhany, Siamack, van den Berkmortel, Franchette W P J, Peters, Natascha A J B, de Bruijn, Peter, Koolen, Stijn L W, Heemskerk, Johan W M, Aarts, Maureen J B, Kuijpers, Marijke J E
Published in BMC cancer (13.06.2022)
Published in BMC cancer (13.06.2022)
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Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow
Cosemans, Judith M.E.M., Schols, Saskia E.M., Stefanini, Lucia, de Witt, Susanne, Feijge, Marion A.H., Hamulyák, Karly, Deckmyn, Hans, Bergmeier, Wolfgang, Heemskerk, Johan W.M.
Published in Blood (13.01.2011)
Published in Blood (13.01.2011)
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Journal Article
Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear
Berny, Michelle A, Munnix, Imke C A, Auger, Jocelyn M, Schols, Saskia E M, Cosemans, Judith M E M, Panizzi, Peter, Bock, Paul E, Watson, Steve P, McCarty, Owen J T, Heemskerk, Johan W M
Published in PloS one (29.04.2010)
Published in PloS one (29.04.2010)
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Journal Article
Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2
Konopatskaya, Olga, Matthews, Sharon A., Harper, Matthew T., Gilio, Karen, Cosemans, Judith M.E.M., Williams, Christopher M., Navarro, Maria N., Carter, Deborah A., Heemskerk, Johan W.M., Leitges, Michael, Cantrell, Doreen, Poole, Alastair W.
Published in Blood (14.07.2011)
Published in Blood (14.07.2011)
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Journal Article
Antithrombotic Potential of Blockers of Store-Operated Calcium Channels in Platelets
van Kruchten, Roger, Braun, Attila, Feijge, Marion A H, Kuijpers, Marijke J E, Rivera-Galdos, Ronmy, Kraft, Peter, Stoll, Guido, Kleinschnitz, Christoph, Bevers, Edouard M, Nieswandt, Bernhard, Heemskerk, Johan W M
Published in Arteriosclerosis, thrombosis, and vascular biology (01.07.2012)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.07.2012)
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