Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
Jackstadt, Rene, van Hooff, Sander R., Leach, Joshua D., Cortes-Lavaud, Xabier, Lohuis, Jeroen O., Ridgway, Rachel A., Wouters, Valérie M., Roper, Jatin, Kendall, Timothy J., Roxburgh, Campbell S., Horgan, Paul G., Nixon, Colin, Nourse, Craig, Gunzer, Matthias, Clark, William, Hedley, Ann, Yilmaz, Omer H., Rashid, Mamunur, Bailey, Peter, Biankin, Andrew V., Campbell, Andrew D., Adams, David J., Barry, Simon T., Steele, Colin W., Medema, Jan Paul, Sansom, Owen J.
Published in Cancer cell (16.09.2019)
Published in Cancer cell (16.09.2019)
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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
Sakamaki, Jun-ichi, Wilkinson, Simon, Hahn, Marcel, Tasdemir, Nilgun, O’Prey, Jim, Clark, William, Hedley, Ann, Nixon, Colin, Long, Jaclyn S., New, Maria, Van Acker, Tim, Tooze, Sharon A., Lowe, Scott W., Dikic, Ivan, Ryan, Kevin M.
Published in Molecular cell (18.05.2017)
Published in Molecular cell (18.05.2017)
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NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
Flanagan, Dustin J, Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J, Gilroy, Kathryn, Raven, Alexander P, Mcgarry, Lynn, Englund, Johanna I, Webb, Anna T, Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C, Ridgway, Rachel A, Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K, Romagnolo, Beatrice, Perret, Christine, Williams, Ann C, Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Jones, E Yvonne, Ristimäki, Ari, Leedham, Simon J, Fish, Paul V, Vincent, Jean-Paul, Katajisto, Pekka, Sansom, Owen J
Published in Nature (London) (17.06.2021)
Published in Nature (London) (17.06.2021)
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Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells
Carruthers, Ross D, Ahmed, Shafiq U, Ramachandran, Shaliny, Strathdee, Karen, Kurian, Kathreena M, Hedley, Ann, Gomez-Roman, Natividad, Kalna, Gabriela, Neilson, Mathew, Gilmour, Lesley, Stevenson, Katrina H, Hammond, Ester M, Chalmers, Anthony J
Published in Cancer research (Chicago, Ill.) (01.09.2018)
Published in Cancer research (Chicago, Ill.) (01.09.2018)
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PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer
Galbraith, Laura C A, Mui, Ernest, Nixon, Colin, Hedley, Ann, Strachan, David, MacKay, Gillian, Sumpton, David, Sansom, Owen J, Leung, Hing Y, Ahmad, Imran
Published in Oncogene (01.04.2021)
Published in Oncogene (01.04.2021)
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Fumarate induces redox-dependent senescence by modifying glutathione metabolism
Zheng, Liang, Cardaci, Simone, Jerby, Livnat, MacKenzie, Elaine D, Sciacovelli, Marco, Johnson, T Isaac, Gaude, Edoardo, King, Ayala, Leach, Joshua D G, Edrada-Ebel, RuAngelie, Hedley, Ann, Morrice, Nicholas A, Kalna, Gabriela, Blyth, Karen, Ruppin, Eytan, Frezza, Christian, Gottlieb, Eyal
Published in Nature communications (23.01.2015)
Published in Nature communications (23.01.2015)
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Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma
Muthalagu, Nathiya, Monteverde, Tiziana, Raffo-Iraolagoitia, Ximena, Wiesheu, Robert, Whyte, Declan, Hedley, Ann, Laing, Sarah, Kruspig, Björn, Upstill-Goddard, Rosanna, Shaw, Robin, Neidler, Sarah, Rink, Curtis, Karim, Saadia A, Gyuraszova, Katarina, Nixon, Colin, Clark, William, Biankin, Andrew V, Carlin, Leo M, Coffelt, Seth B, Sansom, Owen J, Morton, Jennifer P, Murphy, Daniel J
Published in Cancer discovery (01.06.2020)
Published in Cancer discovery (01.06.2020)
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Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
Gay, David M, Ridgway, Rachel A, Müller, Miryam, Hodder, Michael C, Hedley, Ann, Clark, William, Leach, Joshua D, Jackstadt, Rene, Nixon, Colin, Huels, David J, Campbell, Andrew D, Bird, Thomas G, Sansom, Owen J
Published in Nature communications (13.02.2019)
Published in Nature communications (13.02.2019)
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MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer
Casciano, Jessica C, Perry, Caroline, Cohen-Nowak, Adam J, Miller, Katelyn D, Vande Voorde, Johan, Zhang, Qifeng, Chalmers, Susan, Sandison, Mairi E, Liu, Qin, Hedley, Ann, McBryan, Tony, Tang, Hsin-Yao, Gorman, Nicole, Beer, Thomas, Speicher, David W, Adams, Peter D, Liu, Xuefeng, Schlegel, Richard, McCarron, John G, Wakelam, Michael J O, Gottlieb, Eyal, Kossenkov, Andrew V, Schug, Zachary T
Published in British journal of cancer (17.03.2020)
Published in British journal of cancer (17.03.2020)
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Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion
Marco, Sergi, Neilson, Matthew, Moore, Madeleine, Perez-Garcia, Arantxa, Hall, Holly, Mitchell, Louise, Lilla, Sergio, Blanco, Giovani R, Hedley, Ann, Zanivan, Sara, Norman, Jim C
Published in Nature communications (24.11.2021)
Published in Nature communications (24.11.2021)
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Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging
Freckmann, Eva C, Sandilands, Emma, Cumming, Erin, Neilson, Matthew, Román-Fernández, Alvaro, Nikolatou, Konstantina, Nacke, Marisa, Lannagan, Tamsin R M, Hedley, Ann, Strachan, David, Salji, Mark, Morton, Jennifer P, McGarry, Lynn, Leung, Hing Y, Sansom, Owen J, Miller, Crispin J, Bryant, David M
Published in Nature communications (09.09.2022)
Published in Nature communications (09.09.2022)
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SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer
Martinez, Rafael S, Salji, Mark J, Rushworth, Linda, Ntala, Chara, Rodriguez Blanco, Giovanny, Hedley, Ann, Clark, William, Peixoto, Paul, Hervouet, Eric, Renaude, Elodie, Kung, Sonia H Y, Galbraith, Laura C A, Nixon, Colin, Lilla, Sergio, MacKay, Gillian M, Fazli, Ladan, Gaughan, Luke, Sumpton, David, Gleave, Martin E, Zanivan, Sara, Blomme, Arnaud, Leung, Hing Y
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress
Port, Jennifer, Muthalagu, Nathiya, Raja, Meera, Ceteci, Fatih, Monteverde, Tiziana, Kruspig, Björn, Hedley, Ann, Kalna, Gabriela, Lilla, Sergio, Neilson, Lisa, Brucoli, Martina, Gyuraszova, Katarina, Tait-Mulder, Jacqueline, Mezna, Mokdad, Svambaryte, Silvija, Bryson, Amy, Sumpton, David, McVie, Allan, Nixon, Colin, Drysdale, Martin, Esumi, Hiroyasu, Murray, Graeme I, Sansom, Owen J, Zanivan, Sara R, Murphy, Daniel J
Published in Cancer discovery (01.05.2018)
Published in Cancer discovery (01.05.2018)
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Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix
Kay, Emily J, Paterson, Karla, Riera-Domingo, Carla, Sumpton, David, Däbritz, J Henry M, Tardito, Saverio, Boldrini, Claudia, Hernandez-Fernaud, Juan R, Athineos, Dimitris, Dhayade, Sandeep, Stepanova, Ekaterina, Gjerga, Enio, Neilson, Lisa J, Lilla, Sergio, Hedley, Ann, Koulouras, Grigorios, McGregor, Grace, Jamieson, Craig, Johnson, Radia Marie, Park, Morag, Kirschner, Kristina, Miller, Crispin, Kamphorst, Jurre J, Loayza-Puch, Fabricio, Saez-Rodriguez, Julio, Mazzone, Massimiliano, Blyth, Karen, Zagnoni, Michele, Zanivan, Sara
Published in Nature metabolism (01.06.2022)
Published in Nature metabolism (01.06.2022)
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Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
Flanagan, Dustin J, Amirkhah, Raheleh, Vincent, David F, Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J, McCorry, Amy M B, Fisher, Natalie C, Davis, Hayley L, Ridgway, Rachel A, Lohuis, Jeroen, Leach, Joshua D G, Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K, Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L, Kerr, Emma M, Longley, Daniel B, Ginty, Fiona, Cho, Sanghee, Coleman, Helen G, Loughrey, Maurice B, Bardelli, Alberto, Maughan, Timothy S, Campbell, Andrew D, Lawler, Mark, Leedham, Simon J, Barry, Simon T, Inman, Gareth J, van Rheenen, Jacco, Dunne, Philip D, Sansom, Owen J
Published in Nature communications (07.12.2022)
Published in Nature communications (07.12.2022)
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BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration
Loveridge, Carolyn J, Slater, Sarah, Campbell, Kirsteen J, Nam, Noor A, Knight, John, Ahmad, Imran, Hedley, Ann, Lilla, Sergio, Repiscak, Peter, Patel, Rachana, Salji, Mark, Fleming, Janis, Mitchell, Louise, Nixon, Colin, Strathdee, Douglas, Neilson, Matthew, Ntala, Chara, Bryson, Sheila, Zanivan, Sara, Edwards, Joanne, Robson, Craig N, Goodyear, Carl S, Blyth, Karen, Leung, Hing Y
Published in Oncogene (01.02.2020)
Published in Oncogene (01.02.2020)
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Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
Flanagan, Dustin J, Amirkhah, Raheleh, Vincent, David F, Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J, McCorry, Amy M B, Fisher, Natalie C, Davis, Hayley L, Ridgway, Rachel A, Lohuis, Jeroen, Leach, Joshua D G, Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K, Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L, Kerr, Emma M, Longley, Daniel B, Ginty, Fiona, Cho, Sanghee, Coleman, Helen G, Loughrey, Maurice B, Bardelli, Alberto, Maughan, Timothy S, Campbell, Andrew D, Lawler, Mark, Leedham, Simon J, Barry, Simon T, Inman, Gareth J, van Rheenen, Jacco, Dunne, Philip D, Sansom, Owen J
Published in Nature communications (31.01.2023)
Published in Nature communications (31.01.2023)
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Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis
Taurino, Giuseppe, Deshmukh, Ruhi, Villar, Victor H., Chiu, Martina, Shaw, Robin, Hedley, Ann, Shokry, Engy, Sumpton, David, Dander, Erica, D'Amico, Giovanna, Bussolati, Ovidio, Tardito, Saverio
Published in Molecular metabolism (Germany) (01.09.2022)
Published in Molecular metabolism (Germany) (01.09.2022)
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Transcriptome profiling of developmental and xenobiotic responses in a keystone soil animal, the oligochaete annelid Lumbricus rubellus
Owen, Jennifer, Hedley, B Ann, Svendsen, Claus, Wren, Jodie, Jonker, Martijs J, Hankard, Peter K, Lister, Linsey J, Stürzenbaum, Stephen R, Morgan, A John, Spurgeon, David J, Blaxter, Mark L, Kille, Peter
Published in BMC genomics (03.06.2008)
Published in BMC genomics (03.06.2008)
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Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1
Patel, Rachana, Fleming, Janis, Mui, Ernest, Loveridge, Carolyn, Repiscak, Peter, Blomme, Arnaud, Harle, Victoria, Salji, Mark, Ahmad, Imran, Teo, Katy, Hamdy, Freddie C, Hedley, Ann, van den Broek, Niels, Mackay, Gillian, Edwards, Joanne, Sansom, Owen J, Leung, Hing Y
Published in EMBO molecular medicine (01.04.2018)
Published in EMBO molecular medicine (01.04.2018)
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