A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens
Roberts, Kade D., Zhu, Yan, Azad, Mohammad A. K., Han, Mei-Ling, Wang, Jiping, Wang, Lynn, Yu, Heidi H., Horne, Andrew S., Pinson, Jo-Anne, Rudd, David, Voelcker, Nicolas H., Patil, Nitin A., Zhao, Jinxin, Jiang, Xukai, Lu, Jing, Chen, Ke, Lomovskaya, Olga, Hecker, Scott J., Thompson, Philip E., Nation, Roger L., Dudley, Michael N., Griffith, David C., Velkov, Tony, Li, Jian
Published in Nature communications (25.03.2022)
Published in Nature communications (25.03.2022)
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Journal Article
Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases
Hecker, Scott J, Reddy, K. Raja, Lomovskaya, Olga, Griffith, David C, Rubio-Aparicio, Debora, Nelson, Kirk, Tsivkovski, Ruslan, Sun, Dongxu, Sabet, Mojgan, Tarazi, Ziad, Parkinson, Jonathan, Totrov, Maxim, Boyer, Serge H, Glinka, Tomasz W, Pemberton, Orville A, Chen, Yu, Dudley, Michael N
Published in Journal of medicinal chemistry (23.07.2020)
Published in Journal of medicinal chemistry (23.07.2020)
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Journal Article
Cu-Catalyzed Decarboxylative Borylation
Wang, Jie, Shang, Ming, Lundberg, Helena, Feu, Karla S, Hecker, Scott J, Qin, Tian, Blackmond, Donna G, Baran, Phil S
Published in ACS catalysis (05.10.2018)
Published in ACS catalysis (05.10.2018)
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Journal Article
Discovery of a Cyclic Boronic Acid β‑Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases
Hecker, Scott J, Reddy, K. Raja, Totrov, Maxim, Hirst, Gavin C, Lomovskaya, Olga, Griffith, David C, King, Paula, Tsivkovski, Ruslan, Sun, Dongxu, Sabet, Mojgan, Tarazi, Ziad, Clifton, Matthew C, Atkins, Kateri, Raymond, Amy, Potts, Kristy T, Abendroth, Jan, Boyer, Serge H, Loutit, Jeffrey S, Morgan, Elizabeth E, Durso, Stephanie, Dudley, Michael N
Published in Journal of medicinal chemistry (14.05.2015)
Published in Journal of medicinal chemistry (14.05.2015)
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Journal Article
Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees
CARROLL, Steven S, KOEPLINGER, Kenneth, FUJITAKI, James M, BOYER, Serge H, LINEMEYER, David L, HECKER, Scott J, ERION, Mark D, VAVREK, Marissa, NANYAN RENA ZHANG, HANDT, Laurence, MACCOSS, Malcolm, OLSEN, David B, RAJA REDDY, K, ZHILI SUN, VAN POELJE, Paul D
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
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Journal Article
Selection of QPX7831, an Orally Bioavailable Prodrug of Boronic Acid β‑Lactamase Inhibitor QPX7728
Reddy, K. Raja, Parkinson, Jonathan, Sabet, Mojgan, Tarazi, Ziad, Boyer, Serge H, Lomovskaya, Olga, Griffith, David C, Hecker, Scott J, Dudley, Michael N
Published in Journal of medicinal chemistry (09.12.2021)
Published in Journal of medicinal chemistry (09.12.2021)
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Journal Article
Methodology for Monobactam Diversification: Syntheses and Studies of 4‑Thiomethyl Substituted β‑Lactams with Activity against Gram-Negative Bacteria, Including Carbapenemase Producing Acinetobacter baumannii
Carosso, Serena, Liu, Rui, Miller, Patricia A, Hecker, Scott J, Glinka, Tomasz, Miller, Marvin J
Published in Journal of medicinal chemistry (09.11.2017)
Published in Journal of medicinal chemistry (09.11.2017)
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Journal Article
Broad-spectrum cyclic boronate β-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability
Raja Reddy, K., Totrov, Maxim, Lomovskaya, Olga, Griffith, David C., Tarazi, Ziad, Clifton, Matthew C., Hecker, Scott J.
Published in Bioorganic & medicinal chemistry (15.05.2022)
Published in Bioorganic & medicinal chemistry (15.05.2022)
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Journal Article
Scalable Synthesis of β‑Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate
Boyer, Serge H, Gonzalez-de-Castro, Angela, Dielemans, J.A. Hubertus, Lefort, Laurent, Zhu, Zuolin, Gnahn, Matthias, Schörghuber, Julia, Steinhofer, Stefan, de Vries, André H. M, Hecker, Scott J
Published in Organic process research & development (18.03.2022)
Published in Organic process research & development (18.03.2022)
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Journal Article
Scalable On-Demand Production of Purified Diazomethane Suitable for Sensitive Catalytic Reactions
Sheeran, Jillian W, Campbell, Kiersten, Breen, Christopher P, Hummel, Gerald, Huang, Changfeng, Datta, Anamika, Boyer, Serge H, Hecker, Scott J, Bio, Matthew M, Fang, Yuan-Qing, Ford, David D, Russell, M. Grace
Published in Organic process research & development (19.03.2021)
Published in Organic process research & development (19.03.2021)
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Journal Article
Quantitative Structure−Activity Relationships among Macrolide Antibacterial Agents: In Vitro and in Vivo Potency against Pasteurella multocida
McFarland, James W, Berger, Cynthia M, Froshauer, Susan A, Hayashi, Shigeru F, Hecker, Scott J, Jaynes, Burton H, Jefson, Martin R, Kamicker, Barbara J, Lipinski, Christopher A, Lundy, Kristin M, Reese, Catherine P, Vu, Chi B
Published in Journal of medicinal chemistry (25.04.1997)
Published in Journal of medicinal chemistry (25.04.1997)
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Journal Article
Stereochemical Elucidation and Total Synthesis of Dihydropacidamycin D, a Semisynthetic Pacidamycin
Boojamra, Constantine G, Lemoine, Rémy C, Lee, Julie C, Léger, Roger, Stein, Karin A, Vernier, Nicole G, Magon, Angela, Lomovskaya, Olga, Martin, Patrick K, Chamberland, Suzanne, Lee, May D, Hecker, Scott J, Lee, Ving J
Published in Journal of the American Chemical Society (07.02.2001)
Published in Journal of the American Chemical Society (07.02.2001)
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Journal Article
Synthesis of base-modified dihydropacidamycins
LEMOINE, Rémy C, MAGON, Angela, HECKER, Scott J
Published in Bioorganic & medicinal chemistry letters (08.04.2002)
Published in Bioorganic & medicinal chemistry letters (08.04.2002)
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Journal Article
A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis
Gómez-Galeno, Jorge E, Dang, Qun, Nguyen, Thanh H, Boyer, Serge H, Grote, Matthew P, Sun, Zhili, Chen, Mingwei, Craigo, William A, van Poelje, Paul D, MacKenna, Deidre A, Cable, Edward E, Rolzin, Paul A, Finn, Patricia D, Chi, Bert, Linemeyer, David L, Hecker, Scott J, Erion, Mark D
Published in ACS medicinal chemistry letters (09.12.2010)
Published in ACS medicinal chemistry letters (09.12.2010)
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Journal Article
Synthesis and Biological Evaluation of a Series of Liver-Selective Phosphonic Acid Thyroid Hormone Receptor Agonists and Their Prodrugs
Boyer, Serge H, Jiang, Hongjian, Jacintho, Jason D, Reddy, Mali Venkat, Li, Haiqing, Li, Wenyu, Godwin, Jennifer L, Schulz, William G, Cable, Edward E, Hou, Jinzhao, Wu, Rongrong, Fujitaki, James M, Hecker, Scott J, Erion, Mark D
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
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Journal Article
Inhibitors of Efflux Pumps in Pseudomonas aeruginosa Potentiate the Activity of the Fluoroquinolone Antibacterial Levofloxacin
RENAU, Thomas E., LéGER, Roger, FLAMME, Eric M., SANGALANG, Joan, SHE, Miles W., YEN, Rose, GANNON, Carla L., GRIFFITH, David, CHAMBERLAND, Suzanne, LOMOVSKAYA, Olga, HECKER, Scott J., LEE, Ving J., OHTA, Toshiharu, NAKAYAMA, Kiyoshi
Published in Journal of medicinal chemistry (02.12.1999)
Published in Journal of medicinal chemistry (02.12.1999)
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Journal Article
Liver-Targeted Prodrugs of 2‘-C-Methyladenosine for Therapy of Hepatitis C Virus Infection
Hecker, Scott J, Reddy, K. Raja, van Poelje, Paul D, Sun, Zhili, Huang, Wenjian, Varkhedkar, Vaibhav, Reddy, M. Venkat, Fujitaki, James M, Olsen, David B, Koeplinger, Kenneth A, Boyer, Serge H, Linemeyer, David L, MacCoss, Malcolm, Erion, Mark D
Published in Journal of medicinal chemistry (09.08.2007)
Published in Journal of medicinal chemistry (09.08.2007)
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