Structure−Function Studies on the New Growth Hormone-Releasing Peptide, Ghrelin: Minimal Sequence of Ghrelin Necessary for Activation of Growth Hormone Secretagogue Receptor 1a
Bednarek, Maria A, Feighner, Scott D, Pong, Sheng-Shung, McKee, Karen Kulju, Hreniuk, Donna L, Silva, Maria V, Warren, Vivien A, Howard, Andrew D, Van der Ploeg, Lex H. Y, Heck, James V
Published in Journal of medicinal chemistry (16.11.2000)
Published in Journal of medicinal chemistry (16.11.2000)
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Novel 2,3-Dihydrobenzofuran-2-carboxylic Acids: Highly Potent and Subtype-Selective PPARα Agonists with Potent Hypolipidemic Activity
Shi, Guo Q, Dropinski, James F, Zhang, Yong, Santini, Conrad, Sahoo, Soumya P, Berger, Joel P, MacNaul, Karen L, Zhou, Gaochao, Agrawal, Arun, Alvaro, Raul, Cai, Tian-quan, Hernandez, Melba, Wright, Samuel D, Moller, David E, Heck, James V, Meinke, Peter T
Published in Journal of medicinal chemistry (25.08.2005)
Published in Journal of medicinal chemistry (25.08.2005)
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Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice
Zhang, Bei, Salituro, Gino, Szalkowski, Deborah, Li, Zhihua, Zhang, Yan, Royo, Inmaculada, Vilella, Dolores, Díez, Maria Teresa, Pelaez, Fernando, Ruby, Caroline, Kendall, Richard L., Mao, Xianzhi, Griffin, Patrick, Calaycay, Jimmy, Zierath, Juleen R., Heck, James V., Smith, Roy G., Moller, David E.
Published in Science (American Association for the Advancement of Science) (07.05.1999)
Published in Science (American Association for the Advancement of Science) (07.05.1999)
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Design and Synthesis of α-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPARα/γ Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity
Shi, Guo Q, Dropinski, James F, McKeever, Brian M, Xu, Shihua, Becker, Joseph W, Berger, Joel P, MacNaul, Karen L, Elbrecht, Alex, Zhou, Gaochao, Doebber, Thomas W, Wang, Peiran, Chao, Yu-Sheng, Forrest, Mike, Heck, James V, Moller, David E, Jones, A. Brian
Published in Journal of medicinal chemistry (30.06.2005)
Published in Journal of medicinal chemistry (30.06.2005)
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Synthesis of pochoxime prodrugs as potent HSP90 inhibitors
Wang, Cuihua, Barluenga, Sofia, Koripelly, Girish K., Fontaine, Jean-Gonzague, Chen, Ruihong, Yu, Jin-Chen, Shen, Xiaodong, Chabala, John C., Heck, James V., Rubenstein, Allan, Winssinger, Nicolas
Published in Bioorganic & medicinal chemistry letters (15.07.2009)
Published in Bioorganic & medicinal chemistry letters (15.07.2009)
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Discovery of a Potent, Highly Selective, and Orally Efficacious Small-Molecule Activator of the Insulin Receptor
Liu, Kun, Xu, Libo, Szalkowski, Deborah, Li, Zhihua, Ding, Victor, Kwei, Gloria, Huskey, Su, Moller, David E, Heck, James V, Zhang, Bei B, Jones, A. Brian
Published in Journal of medicinal chemistry (21.09.2000)
Published in Journal of medicinal chemistry (21.09.2000)
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5-Aryl thiazolidine-2,4-diones: discovery of PPAR dual α/γ agonists as antidiabetic agents
Desai, Ranjit C., Han, Wei, Metzger, Edward J., Bergman, Jeffrey P., Gratale, Dominick F., MacNaul, Karen L., Berger, Joel P., Doebber, Thomas W., Leung, Kwan, Moller, David E., Heck, James V., Sahoo, Soumya P.
Published in Bioorganic & medicinal chemistry letters (18.08.2003)
Published in Bioorganic & medicinal chemistry letters (18.08.2003)
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Journal Article
(2R)-2-Ethylchromane-2-carboxylic Acids: Discovery of Novel PPARα/γ Dual Agonists as Antihyperglycemic and Hypolipidemic Agents
Koyama, Hiroo, Miller, Daniel J, Boueres, Julia K, Desai, Ranjit C, Jones, A. Brian, Berger, Joel P, MacNaul, Karen L, Kelly, Linda J, Doebber, Thomas W, Wu, Margaret S, Zhou, Gaochao, Wang, Pei-ran, Ippolito, Marc C, Chao, Yu-Sheng, Agrawal, Arun K, Franklin, Ronald, Heck, James V, Wright, Samuel D, Moller, David E, Sahoo, Soumya P
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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A Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist Demonstrates Favorable Effects on Lipid Homeostasis
Guo, Qiu, Sahoo, Soumya P, Wang, Pei-Ran, Milot, Denise P, Ippolito, Marc C, Wu, Margaret S, Baffic, Joanne, Biswas, Chhabi, Hernandez, Melba, Lam, My-Hanh, Sharma, Neelam, Han, Wei, Kelly, Linda J, MacNaul, Karen L, Zhou, Gaochao, Desai, Ranjit, Heck, James V, Doebber, Thomas W, Berger, Joel P, Moller, David E, Sparrow, Carl P, Chao, Yu-sheng, Wright, Samuel D
Published in Endocrinology (Philadelphia) (01.04.2004)
Published in Endocrinology (Philadelphia) (01.04.2004)
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Journal Article
Design and synthesis of potent and subtype-selective PPARα agonists
Desai, Ranjit C., Metzger, Edward, Santini, Conrad, Meinke, Peter T., Heck, James V., Berger, Joel P., MacNaul, Karen L., Cai, Tian-quan, Wright, Samuel D., Agrawal, Arun, Moller, David E., Sahoo, Soumya P.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Journal Article
Aryloxazolidinediones: Identification of potent orally active PPAR dual α/γ agonists
DESAI, Ranjit C, GRATALE, Dominick F, FRANKLIN, Ronald, MOLLER, David E, HECK, James V, SAHOO, Soumya P, WEI HAN, KOYAMA, Hiroo, METZGER, Edward, LOMBARDO, Victoria K, MACNAUL, Karen L, DOEBBER, Thomas W, BERGER, Joel P, LEUNG, Kwan
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
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Journal Article
5-Aryl thiazolidine-2,4-diones as selective PPARγ agonists
Koyama, Hiroo, Boueres, Julia K, Han, Wei, Metzger, Edward J, Bergman, Jeffrey P, Gratale, Dominick F, Miller, Daniel J, Tolman, Richard L, MacNaul, Karen L, Berger, Joel P, Doebber, Thomas W, Leung, Kwan, Moller, David E, Heck, James V, Sahoo, Soumya P
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
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Activation of Insulin Signal Transduction Pathway and Anti-diabetic Activity of Small Molecule Insulin Receptor Activators
Qureshi, Sajjad A., Ding, Victor, Li, Zhihua, Szalkowski, Deborah, Biazzo-Ashnault, Dawn E., Xie, Dan, Saperstein, Richard, Brady, Edward, Huskey, Su, Shen, Xiaolan, Liu, Kun, Xu, Libo, Salituro, Gino M., Heck, James V., Moller, David E., Jones, A. Brian, Zhang, Bei B.
Published in The Journal of biological chemistry (24.11.2000)
Published in The Journal of biological chemistry (24.11.2000)
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Molecular recognition directed self-assembly of supramolecular cylindrical channel-like architectures from 6,7,9,10,12,13,15,16-octahydro-1,4,7,10,13-pentaoxabenzocyclopentadecen-2-ylmethyl 3,4,5-tris(p-dodecyloxybenzyl-oxy)benzoate
PERCEC, V, JOHANSSON, G, HECK, J, UNGAR, G, BATTY, S. V
Published in Journal of the Chemical Society, Perkin Transactions 1 (1993)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1993)
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Crosslinkable coating compostions formulated with dormant carbamate initiator
GUPTA RAJNI, IJDO WOUTER, HECK JAMES A, CHEN YANHUI, DESHMUKH PRASHANT, HOYTE WAYNE, GRAY MAURICE
Year of Publication 11.10.2022
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Year of Publication 11.10.2022
Patent
Preparation and structure-activity relationships of simplified analogs of the antifungal agent cilofungin: a total synthesis approach
Zambias, Robert A, Hammond, Milton L, Heck, James V, Bartizal, Ken, Trainor, Charlotte, Abruzzo, George, Schmatz, Dennis M, Nollstadt, Karl M
Published in Journal of medicinal chemistry (01.07.1992)
Published in Journal of medicinal chemistry (01.07.1992)
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Comparison of the supramolecular structures formed by a polymethacrylate with a highly tapered side chain and its monomeric precursor
Kwon, Yong Ku, Danko, Craig, Chvalun, Sergei, Blackwell, John, Heck, James A, Percec, Virgil
Published in Macromolecular symposia. (01.11.1994)
Published in Macromolecular symposia. (01.11.1994)
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