Pharmacological brake-release of mRNA translation enhances cognitive memory
Sidrauski, Carmela, Acosta-Alvear, Diego, Khoutorsky, Arkady, Vedantham, Punitha, Hearn, Brian R, Li, Han, Gamache, Karine, Gallagher, Ciara M, Ang, Kenny K-H, Wilson, Chris, Okreglak, Voytek, Ashkenazi, Avi, Hann, Byron, Nader, Karim, Arkin, Michelle R, Renslo, Adam R, Sonenberg, Nahum, Walter, Peter
Published in eLife (28.05.2013)
Published in eLife (28.05.2013)
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Journal Article
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response
Sidrauski, Carmela, Tsai, Jordan C, Kampmann, Martin, Hearn, Brian R, Vedantham, Punitha, Jaishankar, Priyadarshini, Sokabe, Masaaki, Mendez, Aaron S, Newton, Billy W, Tang, Edward L, Verschueren, Erik, Johnson, Jeffrey R, Krogan, Nevan J, Fraser, Christopher S, Weissman, Jonathan S, Renslo, Adam R, Walter, Peter
Published in eLife (15.04.2015)
Published in eLife (15.04.2015)
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Journal Article
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch
Gallagher, Ciara M, Garri, Carolina, Cain, Erica L, Ang, Kenny Kean-Hooi, Wilson, Christopher G, Chen, Steven, Hearn, Brian R, Jaishankar, Priyadarshini, Aranda-Diaz, Andres, Arkin, Michelle R, Renslo, Adam R, Walter, Peter
Published in eLife (20.07.2016)
Published in eLife (20.07.2016)
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Journal Article
Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6
Heise, Christopher E, Murray, Jeremy, Augustyn, Katherine E, Bravo, Brandon, Chugha, Preeti, Cohen, Frederick, Giannetti, Anthony M, Gibbons, Paul, Hannoush, Rami N, Hearn, Brian R, Jaishankar, Priyadarshini, Ly, Cuong Q, Shah, Kinjalkumar, Stanger, Karen, Steffek, Micah, Tang, Yinyan, Zhao, Xianrui, Lewcock, Joseph W, Renslo, Adam R, Flygare, John, Arkin, Michelle R
Published in PloS one (05.12.2012)
Published in PloS one (05.12.2012)
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Journal Article
In Vitro-In Vivo Correlation for the Degradation of Tetra-PEG Hydrogel Microspheres with Tunable β-Eliminative Crosslink Cleavage Rates
Santi, Daniel V., Ashley, Gary W., Wang, Donghui, Malato, Julia, Schneider, Eric L., Pfaff, Samuel J., Hearn, Brian R., Fontaine, Shaun D., Henise, Jeff, Hann, Byron
Published in International journal of polymer science (01.01.2019)
Published in International journal of polymer science (01.01.2019)
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Journal Article
USP7 small-molecule inhibitors interfere with ubiquitin binding
Kategaya, Lorna, Di Lello, Paola, Rougé, Lionel, Pastor, Richard, Clark, Kevin R., Drummond, Jason, Kleinheinz, Tracy, Lin, Eva, Upton, John-Paul, Prakash, Sumit, Heideker, Johanna, McCleland, Mark, Ritorto, Maria Stella, Alessi, Dario R., Trost, Matthias, Bainbridge, Travis W., Kwok, Michael C. M., Ma, Taylur P., Stiffler, Zachary, Brasher, Bradley, Tang, Yinyan, Jaishankar, Priyadarshini, Hearn, Brian R., Renslo, Adam R., Arkin, Michelle R., Cohen, Frederick, Yu, Kebing, Peale, Frank, Gnad, Florian, Chang, Matthew T., Klijn, Christiaan, Blackwood, Elizabeth, Martin, Scott E., Forrest, William F., Ernst, James A., Ndubaku, Chudi, Wang, Xiaojing, Beresini, Maureen H., Tsui, Vickie, Schwerdtfeger, Carsten, Blake, Robert A., Murray, Jeremy, Maurer, Till, Wertz, Ingrid E.
Published in Nature (London) (26.10.2017)
Published in Nature (London) (26.10.2017)
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Journal Article
Predicting and Improving the Membrane Permeability of Peptidic Small Molecules
Rafi, Salma B, Hearn, Brian R, Vedantham, Punitha, Jacobson, Matthew P, Renslo, Adam R
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Journal Article
PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89
Beckford Vera, Denis R, Fontaine, Shaun D, VanBrocklin, Henry F, Hearn, Brian R, Reid, Ralph, Ashley, Gary W, Santi, Daniel V
Published in Molecular cancer therapeutics (01.02.2020)
Published in Molecular cancer therapeutics (01.02.2020)
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Journal Article
Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine
Bashore, Charlene, Jaishankar, Priyadarshini, Skelton, Nicholas J, Fuhrmann, Jakob, Hearn, Brian R, Liu, Peter S, Renslo, Adam R, Dueber, Erin C
Published in ACS chemical biology (19.06.2020)
Published in ACS chemical biology (19.06.2020)
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Journal Article
Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation
Özen, Ayşegül, Rougé, Lionel, Bashore, Charlene, Hearn, Brian R., Skelton, Nicholas J., Dueber, Erin C.
Published in Structure (London) (02.01.2018)
Published in Structure (London) (02.01.2018)
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Journal Article
Semisynthesis and Cytotoxicity of Hypothemycin Analogues
Hearn, Brian R., Sundermann, Kurt, Cannoy, Jonah, Santi, Daniel V.
Published in ChemMedChem (12.11.2007)
Published in ChemMedChem (12.11.2007)
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Journal Article
Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system
Hearn, Brian R., Fontaine, Shaun D., Pfaff, Samuel J., Schneider, Eric L., Henise, Jeff, Ashley, Gary W., Santi, Daniel V.
Published in Journal of controlled release (28.05.2018)
Published in Journal of controlled release (28.05.2018)
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Journal Article
A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP‑1 Receptor Agonist
Schneider, Eric L, Hearn, Brian R, Pfaff, Samuel J, Reid, Ralph, Parkes, David G, Vrang, Niels, Ashley, Gary W, Santi, Daniel V
Published in ACS chemical biology (18.08.2017)
Published in ACS chemical biology (18.08.2017)
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Journal Article
Surgical sealants with tunable swelling, burst pressures, and biodegradation rates
Henise, Jeff, Hearn, Brian R, Santi, Daniel V, Kamata, Hiroyuki, Sakai, Takamasa, Ashley, Gary W
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01.08.2017)
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01.08.2017)
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Journal Article
Biodegradable Tetra-PEG Hydrogels as Carriers for a Releasable Drug Delivery System
Henise, Jeff, Hearn, Brian R, Ashley, Gary W, Santi, Daniel V
Published in Bioconjugate chemistry (18.02.2015)
Published in Bioconjugate chemistry (18.02.2015)
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Journal Article
Broad-Spectrum Allosteric Inhibition of Herpesvirus Proteases
Gable, Jonathan E, Lee, Gregory M, Jaishankar, Priyadarshini, Hearn, Brian R, Waddling, Christopher A, Renslo, Adam R, Craik, Charles S
Published in Biochemistry (Easton) (22.07.2014)
Published in Biochemistry (Easton) (22.07.2014)
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Journal Article
Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake
Schneider, Eric L, Hearn, Brian R, Pfaff, Samuel J, Fontaine, Shaun D, Reid, Ralph, Ashley, Gary W, Grabulovski, Stefanie, Strassberger, Verena, Vogt, Lorenz, Jung, Thomas, Santi, Daniel V
Published in Bioconjugate chemistry (19.10.2016)
Published in Bioconjugate chemistry (19.10.2016)
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Journal Article
Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response
Hearn, Brian R., Jaishankar, Priyadarshini, Sidrauski, Carmela, Tsai, Jordan C., Vedantham, Punitha, Fontaine, Shaun D., Walter, Peter, Renslo, Adam R.
Published in ChemMedChem (19.04.2016)
Published in ChemMedChem (19.04.2016)
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Journal Article
High‐throughput, aseptic production of injectable Tetra‐PEG hydrogel microspheres for delivery of releasable covalently bound drugs
Henise, Jeff, Yao, Brian, Hearn, Brian R., Schneider, Eric L., Ashley, Gary W., Santi, Daniel V.
Published in Engineering reports (Hoboken, N.J.) (01.08.2020)
Published in Engineering reports (Hoboken, N.J.) (01.08.2020)
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Journal Article