Scalable Synthesis and Isolation of the Four Stereoisomers of Methyl 1-Amino-3-(4-bromophenyl)cyclopentanecarboxylate, Useful Intermediates for the Synthesis of S1P1 Receptor Agonists
Wallace, Grier A, Gordon, Thomas D, Hayes, Martin E, Konopacki, Donald B, Fix-Stenzel, Shannon R, Zhang, Xiaolei, Grongsaard, Pintipa, Cusack, Kevin P, Schaffter, Lisa M, Henry, Rodger F, Stoffel, Robert H
Published in Journal of organic chemistry (03.07.2009)
Published in Journal of organic chemistry (03.07.2009)
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Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads
Hobson, Adrian D, McPherson, Michael J, Waegell, Wendy, Goess, Christian A, Stoffel, Robert H, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Hernandez, Axel, Bryant, Shaughn H, Mathieu, Suzanne L, Bischoff, Agnieszka K, Fitzgibbons, Julia, Pawlikowska, Martyna, Puthenveetil, Sujiet, Santora, Ling C, Wang, Lu, Wang, Lu, Marvin, Christopher C, Hayes, Martin E, Shrestha, Anurupa, Sarris, Kathy A, Li, Biqin
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody–Drug Conjugates
Marvin, Christopher C., Hobson, Adrian D., McPherson, Michael, Dunstan, Theresa A., Vargo, Thomas R., Hayes, Martin E., Fettis, Margaret M., Bischoff, Agnieszka, Wang, Lu, Wang, Lu, Hernandez, Axel, Jia, Ying, Oh, Jason Z., Tian, Yu
Published in Bioconjugate chemistry (18.10.2023)
Published in Bioconjugate chemistry (18.10.2023)
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Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model
Marvin, Christopher C., Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Bischoff, Agnieszka K., Fitzgibbons, Julia, Wang, Lu, Wang, Lu, Hernandez, Axel, Jia, Ying, Goess, Christian A., Bryant, Shaughn H., Mathieu, Suzanne L., Xu, Jianwen
Published in Journal of medicinal chemistry (13.06.2024)
Published in Journal of medicinal chemistry (13.06.2024)
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Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate
Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Goess, Christian, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Yang, Jindong, Sun, Liang, Zhang, Qiang, Qu, Pei, Yang, Shi, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Santora, Ling C., Wang, Lu, Wang, Lu, Fettis, Margaret M., Li, Xiaofeng, Marvin, Christopher C., Wang, Zhi, Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Henry, Rodger F., Graff, Candace, Tian, Yu, Aguirre, Ana L., Shrestha, Anurupa
Published in Journal of medicinal chemistry (08.12.2022)
Published in Journal of medicinal chemistry (08.12.2022)
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An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases
McPherson, Michael J, Hobson, Adrian D, Hernandez, Jr, Axel, Marvin, Christopher C, Waegell, Wendy, Goess, Christian, Oh, Jason Z, Shi, Dan, Hayes, Martin E, Wang, Lu, Wang, Lu, Schmidt, Diana, Wang, Zhi, Pitney, Victoria, McCarthy, Kimberley, Jia, Ying, Wang, Ce, Kang, Bit Na, Bryant, Shaughn, Mathieu, Suzanne, Ruzek, Melanie, Parmentier, Julie, D'Cunha, Ronilda R, Pang, Yinuo, Phillips, Lucy, Brown, Nathan J, Xu, Jianwen, Graff, Candace, Tian, Yu, Longenecker, Kenton L, Qiu, Wei, Zhu, Haizhong, Liu, Wei, Zheng, Pingping, Bi, Yingtao, Stoffel, Robert
Published in Science translational medicine (20.03.2024)
Published in Science translational medicine (20.03.2024)
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Correction to “Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads”
Hobson, Adrian D., McPherson, Michael J., Waegell, Wendy, Goess, Christian A., Stoffel, Robert H., Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Pawlikowska, Martyna, Puthenveetil, Sujiet, Santora, Ling C., Wang, Lu, Wang, Lu, Marvin, Christopher C., Hayes, Martin E., Shrestha, Anurupa, Sarris, Kathy A., Li, Biqin
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Journal Article
Correction to “Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate”
Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Goess, Christian, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Yang, Jindong, Sun, Liang, Zhang, Qiang, Qu, Pei, Yang, Shi, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Santora, Ling C., Wang, Lu, Wang, Lu, Fettis, Margaret M., Li, Xiaofeng, Marvin, Christopher C., Wang, Zhi, Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Henry, Rodger F., Graff, Candace, Tian, Yu, Aguirre, Ana L., Shrestha, Anurupa
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3
Hayes, Martin E., Wallace, Grier A., Grongsaard, Pintipa, Bischoff, Agnieszka, George, Dawn M., Miao, Wenyan, McPherson, Michael J., Stoffel, Robert H., Green, David W., Roth, Gregory P.
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Journal Article
A stereoselective and scalable synthesis of a conformationally constrained S1P1 agonist
Fix-Stenzel, Shannon R., Hayes, Martin E., Zhang, Xiaolei, Wallace, Grier A., Grongsaard, Pintipa, Schaffter, Lisa M., Hannick, Steven M., Franczyk, Thaddeus S., Stoffel, Robert H., Cusack, Kevin P.
Published in Tetrahedron letters (01.07.2009)
Published in Tetrahedron letters (01.07.2009)
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Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3
Hayes, Martin E., Breinlinger, Eric C., Wallace, Grier A., Grongsaard, Pintipa, Miao, Wenyan, McPherson, Michael J., Stoffel, Robert H., Green, David W., Roth, Gregory P.
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF
HAYES MARTIN E, OH JASON Z, HERNANDEZ JR. AXEL, WAEGELL WENDY, MCPHERSON MICHAEL J, HOBSON ADRIAN D, MARVIN CHRISTOPHER C, GOESS CHRISTIAN, RANDOLPH JOHN T, SCHMIDT DIANA
Year of Publication 29.08.2022
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Year of Publication 29.08.2022
Patent
글루코코르티코이드 수용체 작용제 및 이의 면역접합체
HAYES MARTIN E, OH JASON Z, HERNANDEZ JR. AXEL, WAEGELL WENDY, MCPHERSON MICHAEL J, HOBSON ADRIAN D, MARVIN CHRISTOPHER C, GOESS CHRISTIAN, RANDOLPH JOHN T, SCHMIDT DIANA
Year of Publication 12.02.2019
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Year of Publication 12.02.2019
Patent
Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator
Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Goess, Christian, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Yang, Jindong, Sun, Liang, Zhang, Qiang, Qu, Pei, Yang, Shi, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Santora, Ling C., Wang, Lu, Fettis, Margaret M., Li, Xiaofeng, Marvin, Christopher C., Wang, Zhi, V. Patel, Meena, Schmidt, Diana L., Li, Tongmei, Randolph, John T., Henry, Rodger F., Graff, Candace, Tian, Yu, Aguirre, Ana L., Shrestha, Anurupa
Published in Journal of medicinal chemistry (08.12.2022)
Published in Journal of medicinal chemistry (08.12.2022)
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NUCLEAR HORMONE RECEPTOR MODULATORS
WANG LEI, MARTINEZ GLORIA Y, GORDON THOMAS D, HAYES MARTIN E, ERICSSON ANNA M, IHLE DAVID C, FRIEDMAN MICHAEL, LI BIN, MORYTKO MICHAEL J, CUSACK KEVIN P, HOBSON ADRIAN D, BURCHAT ANDREW, BREINLINGER ERIC C, MULLEN KELLY D
Year of Publication 06.02.2014
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Year of Publication 06.02.2014
Patent
A stereoselective and scalable synthesis of a conformationally constrained S1P(1) agonist
Fix-Stenzel, Shannon R., Hayes, Martin E., Zhang, Xiaolei, Wallace, Grier A., Grongsaard, Pintipa, Schaffter, Lisa M., Hannick, Steven M., Franczyk, Thaddeus S., Stoffel, Robert H., Cusack, Kevin P.
Published in Tetrahedron letters (15.07.2009)
Published in Tetrahedron letters (15.07.2009)
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Journal Article
A stereoselective and scalable synthesis of a conformationally constrained S1P 1 agonist
Fix-Stenzel, Shannon R., Hayes, Martin E., Zhang, Xiaolei, Wallace, Grier A., Grongsaard, Pintipa, Schaffter, Lisa M., Hannick, Steven M., Franczyk, Thaddeus S., Stoffel, Robert H., Cusack, Kevin P.
Published in Tetrahedron letters (2009)
Published in Tetrahedron letters (2009)
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