NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
Hayes, John D., McMahon, Michael
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.04.2009)
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.04.2009)
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Journal Article
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
Cuadrado, Antonio, Rojo, Ana I., Wells, Geoffrey, Hayes, John D., Cousin, Sharon P., Rumsey, William L., Attucks, Otis C., Franklin, Stephen, Levonen, Anna-Liisa, Kensler, Thomas W., Dinkova-Kostova, Albena T.
Published in Nature reviews. Drug discovery (01.04.2019)
Published in Nature reviews. Drug discovery (01.04.2019)
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Journal Article
SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
Rada, Patricia, Rojo, Ana I., Chowdhry, Sudhir, McMahon, Michael, Hayes, John D., Cuadrado, Antonio
Published in Molecular and Cellular Biology (01.03.2011)
Published in Molecular and Cellular Biology (01.03.2011)
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Journal Article
p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
Jain, Ashish, Lamark, Trond, Sjøttem, Eva, Bowitz Larsen, Kenneth, Atesoh Awuh, Jane, Øvervatn, Aud, McMahon, Michael, Hayes, John D., Johansen, Terje
Published in The Journal of biological chemistry (16.07.2010)
Published in The Journal of biological chemistry (16.07.2010)
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Journal Article
Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway
Hayes, John D, McMahon, Michael, Chowdhry, Sudhir, Dinkova-Kostova, Albena T
Published in Antioxidants & redox signaling (01.12.2010)
Published in Antioxidants & redox signaling (01.12.2010)
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Journal Article
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
McMahon, Michael, Lamont, Douglas J., Beattie, Kenneth A., Hayes, John D., Murphy, Mike P.
Published in Proceedings of the National Academy of Sciences - PNAS (02.11.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (02.11.2010)
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Journal Article
Glutathione transferases
HAYES, John D, FLANAGAN, Jack U, JOWSEY, Ian R
Published in Annual review of pharmacology and toxicology (01.01.2005)
Published in Annual review of pharmacology and toxicology (01.01.2005)
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Journal Article
Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis
Rada, Patricia, Rojo, Ana I., Evrard-Todeschi, Nathalie, Innamorato, Nadia G., Cotte, Axelle, Jaworski, Tomasz, Tobón-Velasco, Julio C., Devijver, Herman, García-Mayoral, María Flor, Van Leuven, Fred, Hayes, John D., Bertho, Gildas, Cuadrado, Antonio
Published in Molecular and Cellular Biology (01.09.2012)
Published in Molecular and Cellular Biology (01.09.2012)
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Journal Article
cancer chemopreventive actions of phytochemicals derived from glucosinolates
Hayes, John D, Kelleher, Michael O, Eggleston, Ian M
Published in European journal of nutrition (01.05.2008)
Published in European journal of nutrition (01.05.2008)
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Journal Article
Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha
Wang, Xiu Jun, Hayes, John D, Henderson, Colin J, Wolf, C. Roland
Published in Proceedings of the National Academy of Sciences - PNAS (04.12.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (04.12.2007)
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Journal Article
Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3‑Nitrobenzanthrone in Human Lung Cells
Murray, Jessica R, de la Vega, Laureano, Hayes, John D, Duan, Ling, Penning, Trevor M
Published in Chemical research in toxicology (16.12.2019)
Published in Chemical research in toxicology (16.12.2019)
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Journal Article
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Sharma, Ritu S, Harrison, David J, Kisielewski, Dorothy, Cassidy, Diane M, McNeilly, Alison D, Gallagher, Jennifer R, Walsh, Shaun V, Honda, Tadashi, McCrimmon, Rory J, Dinkova-Kostova, Albena T, Ashford, Michael L.J, Dillon, John F, Hayes, John D
Published in Cellular and molecular gastroenterology and hepatology (01.01.2018)
Published in Cellular and molecular gastroenterology and hepatology (01.01.2018)
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Journal Article
Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression
McMahon, Michael, Itoh, Ken, Yamamoto, Masayuki, Hayes, John D.
Published in The Journal of biological chemistry (13.06.2003)
Published in The Journal of biological chemistry (13.06.2003)
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Journal Article