Discovery of a Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonist Series and Characterization of the Potent, Selective, and Orally Efficacious Agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic Acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] Amide (SEN15924, WAY-361789)
Zanaletti, Riccardo, Bettinetti, Laura, Castaldo, Cristiana, Cocconcelli, Giuseppe, Comery, Thomas, Dunlop, John, Gaviraghi, Giovanni, Ghiron, Chiara, Haydar, Simon N, Jow, Flora, Maccari, Laura, Micco, Iolanda, Nencini, Arianna, Scali, Carla, Turlizzi, Elisa, Valacchi, Michela
Published in Journal of medicinal chemistry (24.05.2012)
Published in Journal of medicinal chemistry (24.05.2012)
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Journal Article
SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist
Haydar, Simon N., Ghiron, Chiara, Bettinetti, Laura, Bothmann, Hendrick, Comery, Thomas A., Dunlop, John, La Rosa, Salvatore, Micco, Iolanda, Pollastrini, Martina, Quinn, Joanna, Roncarati, Renza, Scali, Carla, Valacchi, Michela, Varrone, Maurizio, Zanaletti, Riccardo
Published in Bioorganic & medicinal chemistry (15.07.2009)
Published in Bioorganic & medicinal chemistry (15.07.2009)
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Journal Article
N‑[5-(5-Fluoropyridin-3-yl)‑1H‑pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate
Zanaletti, Riccardo, Bettinetti, Laura, Castaldo, Cristiana, Ceccarelli, Ilaria, Cocconcelli, Giuseppe, Comery, Thomas A, Dunlop, John, Genesio, Eva, Ghiron, Chiara, Haydar, Simon N, Jow, Flora, Maccari, Laura, Micco, Iolanda, Nencini, Arianna, Pratelli, Carmela, Scali, Carla, Turlizzi, Elisa, Valacchi, Michela
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
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Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)
Ghiron, Chiara, Haydar, Simon N, Aschmies, Suzan, Bothmann, Hendrick, Castaldo, Cristiana, Cocconcelli, Giuseppe, Comery, Thomas A, Di, Li, Dunlop, John, Lock, Tim, Kramer, Angela, Kowal, Dianne, Jow, Flora, Grauer, Steve, Harrison, Boyd, La Rosa, Salvatore, Maccari, Laura, Marquis, Karen L, Micco, Iolanda, Nencini, Arianna, Quinn, Joanna, Robichaud, Albert J, Roncarati, Renza, Scali, Carla, Terstappen, Georg C, Turlizzi, Elisa, Valacchi, Michela, Varrone, Maurizio, Zanaletti, Riccardo, Zanelli, Ugo
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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Journal Article
5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT6 Receptor Antagonists
Haydar, Simon N, Yun, Heedong, Andrae, Patrick M, Mattes, James, Zhang, Jean, Kramer, Angela, Smith, Deborah L, Huselton, Christine, Graf, Radka, Aschmies, Suzan, Schechter, Lee E, Comery, Thomas A, Robichaud, Albert J
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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Journal Article
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT6 receptor ligands
Bernotas, Ronald C., Antane, Schuyler A., Lenicek, Steven E., Haydar, Simon N., Robichaud, Albert J., Harrison, Boyd L., Zhang, Guo Ming, Smith, Deborah, Coupet, Joseph, Schechter, Lee E.
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
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Journal Article
N-[5-(5-Fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an alpha 7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate
Zanaletti, Riccardo, Bettinetti, Laura, Castaldo, Cristiana, Ceccarelli, Ilaria, Cocconcelli, Giuseppe, Comery, Thomas A., Dunlop, John, Genesio, Eva, Ghiron, Chiara, Haydar, Simon N., Jow, Flora, Maccari, Laura, Micco, Iolanda, Nencini, Arianna, Fratelli, Carmela, Scali, Carla, Turlizzi, Elisa, Valacchi, Michela
Published in Journal of medicinal chemistry (22.11.2012)
Published in Journal of medicinal chemistry (22.11.2012)
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Journal Article
5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT 6 Receptor Antagonists
Haydar, Simon N., Yun, Heedong, Andrae, Patrick M., Mattes, James, Zhang, Jean, Kramer, Angela, Smith, Deborah L., Huselton, Christine, Graf, Radka, Aschmies, Suzan, Schechter, Lee E., Comery, Thomas A., Robichaud, Albert J.
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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Journal Article
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT sub(6) receptor ligands
Bernotas, Ronald C, Antane, Schuyler A, Lenicek, Steven E, Haydar, Simon N, Robichaud, Albert J, Harrison, Boyd L, Zhang, Guo Ming, Smith, Deborah, Coupet, Joseph, Schechter, Lee E
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
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Journal Article
Novel Oxidation of Cyclosporin A: Preparation of Cyclosporin Methyl Vinyl Ketone (Cs-MVK)
Yang, Zhicai, Pattamana, Kevin, Molino, Bruce F., Haydar, Simon N., Cao, Yeyu, Bois, Frederic, Maeng, Jun-Ho, Hemenway, Michael S., Rich, Joseph O., Khmelnitsky, Yuri L., Friedrich, Thomas D., Peace, Denise, Michels, Peter C.
Published in Synlett (12.11.2009)
Published in Synlett (12.11.2009)
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Corrigendum to “SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist” [Bioorg. Med. Chem. 17 (2009) 5247]
Haydar, Simon N., Ghiron, Chiara, Bettinetti, Laura, Bothmann, Hendrick, Comery, Thomas A., Dunlop, John, La Rosa, Salvatore, Micco, Iolanda, Pollastrini, Martina, Quinn, Joanna, Roncarati, Renza, Scali, Carla, Valacchi, Michela, Varrone, Maurizio, Zanaletti, Riccardo
Published in Bioorganic & medicinal chemistry (2010)
Published in Bioorganic & medicinal chemistry (2010)
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Journal Article
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands
Bernotas, Ronald C, Antane, Schuyler A, Lenicek, Steven E, Haydar, Simon N, Robichaud, Albert J, Harrison, Boyd L, Zhang, Guo Ming, Smith, Deborah, Coupet, Joseph, Schechter, Lee E
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
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Journal Article