Design and synthesis of highly active Alzheimer’s β-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability
Kimura, Tooru, Shuto, Daisuke, Hamada, Yoshio, Igawa, Naoto, Kasai, Soko, Liu, Ping, Hidaka, Koushi, Hamada, Takashi, Hayashi, Yoshio, Kiso, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
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"O-acyl isopeptide method" for peptide synthesis: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH
Yoshiya, Taku, Taniguchi, Atsuhiko, Sohma, Youhei, Fukao, Fukue, Nakamura, Setsuko, Abe, Naoko, Ito, Nui, Skwarczynski, Mariusz, Kimura, Tooru, Hayashi, Yoshio, Kiso, Yoshiaki
Published in Organic & biomolecular chemistry (01.01.2007)
Published in Organic & biomolecular chemistry (01.01.2007)
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BACE1 inhibitors : Optimization by replacing the P1' residue with non-acidic moiety
HAMADA, Yoshio, ABDEL-RAHMAN, Hamdy, KISO, Yoshiaki, YAMANI, Abdellah, NGUYEN, Jeffrey-Tri, STOCHAJ, Monika, HIDAKA, Koushi, KIMURA, Tooru, HAYASHI, Yoshio, SAITO, Kazuki, ISHIURA, Shoichi
Published in Bioorganic & medicinal chemistry letters (01.03.2008)
Published in Bioorganic & medicinal chemistry letters (01.03.2008)
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Design and synthesis of potent β-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres
KIMURA, Tooru, HAMADA, Yoshio, HAYASHI, Yoshio, KISO, Yoshiaki, STOCHAJ, Monika, IKARI, Hayato, NAGAMINE, Ayaka, ABDEL-RAHMAN, Hamdy, IGAWA, Naoto, HIDAKA, Koushi, NGUYEN, Jeffrey-Tri, SAITO, Kazuki
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity
Watanabe, Kazutoshi, Morinaka, Yasuhiro, Hayashi, Yoshio, Shinoda, Masaki, Nishi, Hiroyoshi, Fukushima, Nobuko, Watanabe, Toshiaki, Ishibashi, Akira, Yuki, Satoshi, Tanaka, Masahiko
Published in Bioorganic & medicinal chemistry (15.02.2008)
Published in Bioorganic & medicinal chemistry (15.02.2008)
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Small-Sized Human Immunodeficiency Virus Type-1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S-2 ' Pocket
Hidaka, Koushi, Kimura, Tooru, Abdel-Rahman, Hamdy M., Nguyen, Jeffrey-Tri, McDaniel, Keith F., Kohlbrenner, William E., Molla, Akhteruzzaman, Adachi, Motoyasu, Tamada, Taro, Kuroki, Ryota, Katsuki, Noriko, Tanaka, Yoshiaki, Matsumoto, Hikaru, Wang, Jun, Hayashi, Yoshio, Kempf, Dale J., Kiso, Yoshiaki
Published in Journal of medicinal chemistry (10.12.2009)
Published in Journal of medicinal chemistry (10.12.2009)
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METHOD FOR KILLING PTERIOMORPHIA AND BARNACLES USING LIGHT IRRADIATION
SAITO, SHINSUKE, YAMASHITA, KEIJI, KAMIYA, KYOKO, YANAGAWA, TOSHIHARU, HAYASHI, YOSHIO
Year of Publication 01.10.2015
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Year of Publication 01.10.2015
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METHOD FOR STOPPING SWIMMING OR CRAWLING OF ADHESION-STAGE LARVAE
SAITO, SHINSUKE, YAMASHITA, KEIJI, KAMIYA, KYOKO, YANAGAWA, TOSHIHARU, HAYASHI, YOSHIO
Year of Publication 01.10.2015
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Year of Publication 01.10.2015
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Identification of histaminergic subpopulations involved in activation of the caudal part of the arcuate nucleus of hypothalamus by food deprivation under scheduled feeding
Umehara, Hayato, Fukui, Hiroyuki, Mizuguchi, Hiroyuki, Takeda, Noriaki, Senba, Emiko, Hayashi, Yoshio, Ishimaru, Naozumi
Published in Neuroscience research (01.09.2011)
Published in Neuroscience research (01.09.2011)
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Negamycin Analogue with Readthrough-Promoting Activity as a Potential Drug Candidate for Duchenne Muscular Dystrophy
Taguchi, Akihiro, Nishiguchi, Shigenobu, Shiozuka, Masataka, Nomoto, Takao, Ina, Mayuko, Nojima, Shouta, Matsuda, Ryoichi, Nonomura, Yoshiaki, Kiso, Yoshiaki, Yamazaki, Yuri, Yakushiji, Fumika, Hayashi, Yoshio
Published in ACS medicinal chemistry letters (09.02.2012)
Published in ACS medicinal chemistry letters (09.02.2012)
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KPU-300, a Novel Benzophenone-Diketopiperazine-Type Anti-Microtubule Agent with a 2-Pyridyl Structure, Is a Potent Radiosensitizer That Synchronizes the Cell Cycle in Early M Phase: e0145995
Okuyama, Kohei, Kaida, Atsushi, Hayashi, Yoshiki, Hayashi, Yoshio, Harada, Kiyoshi, Miura, Masahiko
Published in PloS one (01.12.2015)
Published in PloS one (01.12.2015)
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β-Secretase inhibitors : Modification at the P4 position and improvement of inhibitory activity in cultured cells
HAMADA, Yoshio, IGAWA, Naoto, EBINA, Maiko, ISHIURA, Shoichi, KISO, Yoshiaki, IKARI, Hayato, ZIORA, Zyta, NGUYEN, Jeffrey-Tri, YAMANI, Abdellah, HIDAKA, Koushi, KIMURA, Tooru, SAITO, Kazuki, HAYASHI, Yoshio
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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Design and synthesis of potent β-secretase (BACE1) inhibitors with P 1 ′ carboxylic acid bioisosteres
Kimura, Tooru, Hamada, Yoshio, Stochaj, Monika, Ikari, Hayato, Nagamine, Ayaka, Abdel-Rahman, Hamdy, Igawa, Naoto, Hidaka, Koushi, Nguyen, Jeffrey-Tri, Saito, Kazuki, Hayashi, Yoshio, Kiso, Yoshiaki
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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MICROTUBULE DEPOLYMERIZATION AGENT
USUI TATEO, HAYASHI YOSHIKI, TAKAYAMA KENTARO, HAYASHI YOSHIO, YAKUSHIJI FUMIKA
Year of Publication 16.02.2015
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Year of Publication 16.02.2015
Patent
Erratum: Corrigendum: Regulation of naive T cell function by the NF-κB pathway
Ishimaru, Naozumi, Kishimoto, Hidehiro, Hayashi, Yoshio, Sprent, Jonathan
Published in Nature immunology (01.11.2007)
Published in Nature immunology (01.11.2007)
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Corrigendum: Regulation of naive T cell function by the NF-[kappa]B pathway
Ishimaru, Naozumi, Kishimoto, Hidehiro, Hayashi, Yoshio, Sprent, Jonathan
Published in Nature immunology (01.11.2007)
Published in Nature immunology (01.11.2007)
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