Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists
Letavic, Michael A, Lord, Brian, Bischoff, Francois, Hawryluk, Natalie A, Pieters, Serge, Rech, Jason C, Sales, Zachary, Velter, Adriana I, Ao, Hong, Bonaventure, Pascal, Contreras, Victor, Jiang, Xiaohui, Morton, Kirsten L, Scott, Brian, Wang, Qi, Wickenden, Alan D, Carruthers, Nicholas I, Bhattacharya, Anindya
Published in ACS medicinal chemistry letters (11.04.2013)
Published in ACS medicinal chemistry letters (11.04.2013)
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Journal Article
Formal Synthesis of (±)-Guanacastepene A
Shi, Bo, Hawryluk, Natalie A, Snider, Barry B
Published in Journal of organic chemistry (07.02.2003)
Published in Journal of organic chemistry (07.02.2003)
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Journal Article
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists
HAWRYLUK, Natalie A, MERIT, Jeffrey E, FREEDMAN, Jamie M, SCOTT, Brian P, WICKENDEN, Alan D, CHAPLAN, Sandra R, BREITENBUCHER, J. Guy, LEBSACK, Alec D, BRANSTETTER, Bryan J, HACK, Michael D, SWANSON, Nadia, HONG AO, MAHER, Michael P, BHATTACHARYA, Anindya, QI WANG
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Journal Article
1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties
LEBSACK, Alec D, RECH, Jason C, HONG AO, MAHER, Michael P, HERRMANN, Michelle, FREEDMAN, Jamie, SCOTT, Brian P, LIN LUO, BHATTACHARYA, Anindya, QI WANG, CHAPLAN, Sandra R, WICKENDEN, Alan D, BRANSTETTER, Bryan J, BREITENBUCHER, J. Guy, HAWRYLUK, Natalie A, MERIT, Jeffrey E, ALLISON, Brett, RYNBERG, Raymond, BUMA, Johnathan, RIZZOLIO, Michele, SWANSON, Nadia
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Journal Article
Complexation-Induced Unfolding of Heterocyclic Ureas. Simple Foldamers Equilibrate with Multiply Hydrogen-Bonded Sheetlike Structures1
Corbin, Perry S, Zimmerman, Steven C, Thiessen, Paul A, Hawryluk, Natalie A, Murray, Thomas J
Published in Journal of the American Chemical Society (31.10.2001)
Published in Journal of the American Chemical Society (31.10.2001)
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Journal Article
FLAP MODULATORS
KEITH JOHN M, HACK MICHAEL D, JONES WILLIAM M, ECCLES WENDY, MCCLURE KELLY J, ROSEN MARK D, HAWRYLUK NATALIE A, LEBSACK ALEC D, MANI NEELAKANDHA S, KRAWCZUK PAUL, FITZGERALD ANNE E, LIU JING, MEDUNA STEVEN P
Year of Publication 12.01.2016
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Year of Publication 12.01.2016
Patent
Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X(7) Antagonists
Letavic, Michael A., Lord, Brian, Bischoff, Francois, Hawryluk, Natalie A., Pieters, Serge, Rech, Jason C., Sales, Zachary, Velter, Adriana I., Ao, Hong, Bonaventure, Pascal, Contreras, Victor, Jiang, Xiaohui, Morton, Kirsten L., Scott, Brian, Wang, Qi, Wickenden, Alan D., Carruthers, Nicholas I., Bhattacharya, Anindya
Published in ACS medicinal chemistry letters (01.04.2013)
Published in ACS medicinal chemistry letters (01.04.2013)
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Journal Article
2‐Pyridinylpiperazine Carboxamide Class and Related TRPV1 Antagonists
Hawryluk, Natalie A, Carruthers, Nicholas I
Published in Vanilloid Receptor TRPV1 in Drug Discovery (12.02.2010)
Published in Vanilloid Receptor TRPV1 in Drug Discovery (12.02.2010)
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Book Chapter
Discovery and synthesis of 6,7,8,9-tetrahydro-5 H-pyrimido-[4,5- d]azepines as novel TRPV1 antagonists
Hawryluk, Natalie A., Merit, Jeffrey E., Lebsack, Alec D., Branstetter, Bryan J., Hack, Michael D., Swanson, Nadia, Ao, Hong, Maher, Michael P., Bhattacharya, Anindya, Wang, Qi, Freedman, Jamie M., Scott, Brian P., Wickenden, Alan D., Chaplan, Sandra R., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X 7 Antagonists
Letavic, Michael A., Lord, Brian, Bischoff, Francois, Hawryluk, Natalie A., Pieters, Serge, Rech, Jason C., Sales, Zachary, Velter, Adriana I., Ao, Hong, Bonaventure, Pascal, Contreras, Victor, Jiang, Xiaohui, Morton, Kirsten L., Scott, Brian, Wang, Qi, Wickenden, Alan D., Carruthers, Nicholas I., Bhattacharya, Anindya
Published in ACS medicinal chemistry letters (11.04.2013)
Published in ACS medicinal chemistry letters (11.04.2013)
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Journal Article
1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5 H-pyrimido[4,5- d]azepines as TRPV1 antagonists with improved properties
Lebsack, Alec D., Rech, Jason C., Branstetter, Bryan J., Hawryluk, Natalie A., Merit, Jeffrey E., Allison, Brett, Rynberg, Raymond, Buma, Johnathan, Rizzolio, Michele, Swanson, Nadia, Ao, Hong, Maher, Michael P., Herrmann, Michelle, Freedman, Jamie, Scott, Brian P., Luo, Lin, Bhattacharya, Anindya, Wang, Qi, Chaplan, Sandra R., Wickenden, Alan D., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
Complexation-Induced Unfolding of Heterocyclic Ureas. Simple Foldamers Equilibrate with Multiply Hydrogen-Bonded Sheetlike Structures 1
Corbin, Perry S., Zimmerman, Steven C., Thiessen, Paul A., Hawryluk, Natalie A., Murray, Thomas J.
Published in Journal of the American Chemical Society (31.10.2001)
Published in Journal of the American Chemical Society (31.10.2001)
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Journal Article
FLAP MODULATORS
HAWRYLUK, Natalie A, LIU, Jing, KEITH, John M, MCCLURE, Kelly J, ECCLES, Wendy, HACK, Michael D, FITZGERALD, Anne E, LEBSACK, Alec D, MANI, Neelakandha S, JONES, William M, KRAWCZUK, Paul, MEDUNA, Steven P, ROSEN, Mark D
Year of Publication 28.08.2019
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Year of Publication 28.08.2019
Patent