Glycan complexity dictates microbial resource allocation in the large intestine
Rogowski, Artur, Briggs, Jonathon A., Mortimer, Jennifer C., Tryfona, Theodora, Terrapon, Nicolas, Lowe, Elisabeth C., Baslé, Arnaud, Morland, Carl, Day, Alison M., Zheng, Hongjun, Rogers, Theresa E., Thompson, Paul, Hawkins, Alastair R., Yadav, Madhav P., Henrissat, Bernard, Martens, Eric C., Dupree, Paul, Gilbert, Harry J., Bolam, David N.
Published in Nature communications (26.06.2015)
Published in Nature communications (26.06.2015)
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Quinate-based ligands for irreversible inactivation of the bacterial virulence factor DHQ1 enzyme-A molecular insight
Rodríguez, Ángela, Maneiro, María, Lence, Emilio, Otero, José M, van Raaij, Mark J, Thompson, Paul, Hawkins, Alastair R, González-Bello, Concepción
Published in Frontiers in molecular biosciences (24.01.2023)
Published in Frontiers in molecular biosciences (24.01.2023)
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Insights into substrate binding and catalysis in bacterial type I dehydroquinase
Maneiro, María, Peón, Antonio, Lence, Emilio, Otero, José M, Van Raaij, Mark J, Thompson, Paul, Hawkins, Alastair R, González-Bello, Concepción
Published in Biochemical journal (15.09.2014)
Published in Biochemical journal (15.09.2014)
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GTP Cyclohydrolase II Structure and Mechanism
Ren, Jingshan, Kotaka, Masayo, Lockyer, Michael, Lamb, Heather K., Hawkins, Alastair R., Stammers, David K.
Published in The Journal of biological chemistry (04.11.2005)
Published in The Journal of biological chemistry (04.11.2005)
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The Affinity of a Major Ca2+ Binding Site on GRP78 Is Differentially Enhanced by ADP and ATP
Lamb, Heather K., Mee, Christopher, Xu, Weiming, Liu, Lizhi, Blond, Sylvie, Cooper, Alan, Charles, Ian G., Hawkins, Alastair R.
Published in The Journal of biological chemistry (31.03.2006)
Published in The Journal of biological chemistry (31.03.2006)
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Structure-Based Design, Synthesis, and Biological Evaluation of Inhibitors of Mycobacterium tuberculosis Type II Dehydroquinase
SáNCHEZ-SIXTO, Cristina, PRAZERES, Verónica F. V., CASTEDO, Luis, LAMB, Heather, HAWKINS, Alastair R., GONZáLEZ-BELLO, Concepción
Published in Journal of medicinal chemistry (28.07.2005)
Published in Journal of medicinal chemistry (28.07.2005)
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The Negative Transcriptional Regulator NmrA Discriminates between Oxidized and Reduced Dinucleotides
Lamb, Heather K., Leslie, Kris, Dodds, Anna L., Nutley, Margaret, Cooper, Alan, Johnson, Christopher, Thompson, Paul, Stammers, David K., Hawkins, Alastair R.
Published in The Journal of biological chemistry (22.08.2003)
Published in The Journal of biological chemistry (22.08.2003)
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Crystal Structure of SANOS, a Bacterial Nitric Oxide Synthase Oxygenase Protein from Staphylococcus aureus
Bird, Louise E, Ren, Jingshan, Zhang, Jiancheng, Foxwell, Neale, Hawkins, Alastair R, Charles, Ian G, Stammers, David K
Published in Structure (London) (01.12.2002)
Published in Structure (London) (01.12.2002)
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Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase: Synthesis, Biological Evaluation, and NMR Studies
Sánchez-Sixto, Cristina, Prazeres, Verónica F. V., Castedo, Luis, Suh, Se Won, Lamb, Heather, Hawkins, Alastair R., Cañada, Francisco Javier, Jiménez-Barbero, Jesús, González-Bello, Concepción
Published in ChemMedChem (19.05.2008)
Published in ChemMedChem (19.05.2008)
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Journal Article
Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis
Brown, Katherine A, Carpenter, Elisabeth P, Hawkins, Alastair R, Frost, John W
Published in Nature (London) (16.07.1998)
Published in Nature (London) (16.07.1998)
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Crystal structure of NucB, a biofilm-degrading endonuclease
Baslé, Arnaud, Hewitt, Lorraine, Koh, Alan, Lamb, Heather K, Thompson, Paul, Burgess, J Grant, Hall, Michael J, Hawkins, Alastair R, Murray, Heath, Lewis, Richard J
Published in Nucleic acids research (09.01.2018)
Published in Nucleic acids research (09.01.2018)
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Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover
Blanco, Beatriz, Prado, Verónica, Lence, Emilio, Otero, José M, Garcia-Doval, Carmela, van Raaij, Mark J, Llamas-Saiz, Antonio L, Lamb, Heather, Hawkins, Alastair R, González-Bello, Concepción
Published in Journal of the American Chemical Society (21.08.2013)
Published in Journal of the American Chemical Society (21.08.2013)
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Matriptase Induction of Metalloproteinase‐Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms
Wilkinson, David J., Habgood, Angela, Lamb, Heather K., Thompson, Paul, Hawkins, Alastair R., Désilets, Antoine, Leduc, Richard, Steinmetzer, Torsten, Hammami, Maya, Lee, Melody S., Craik, Charles S., Watson, Sharon, Lin, Hua, Milner, Jennifer M., Rowan, Andrew D.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.08.2017)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.08.2017)
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Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase
Prazeres, Verónica F. V., Sánchez-Sixto, Cristina, Castedo, Luis, Lamb, Heather, Hawkins, Alastair R., Riboldi-Tunnicliffe, Alan, Coggins, John R., Lapthorn, Adrian J., González-Bello, Concepción
Published in ChemMedChem (12.02.2007)
Published in ChemMedChem (12.02.2007)
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Synthesis of rigidified shikimic acid derivatives by ring-closing metathesis to imprint inhibitor efficacy against shikimate kinase enzyme
Pernas, Marina, Blanco, Beatriz, Lence, Emilio, Thompson, Paul, Hawkins, Alastair R., Gonzalez-Bello, Concepcion
Published in ORGANIC CHEMISTRY FRONTIERS (09.07.2019)
Published in ORGANIC CHEMISTRY FRONTIERS (09.07.2019)
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Frontispiece: Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme
Prado, Verónica, Lence, Emilio, Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción
Published in Chemistry : a European journal (12.12.2016)
Published in Chemistry : a European journal (12.12.2016)
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