Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma
Hansen, Joshua D, Correa, Matthew, Nagy, Mark A, Alexander, Matt, Plantevin, Veronique, Grant, Virginia, Whitefield, Brandon, Huang, Dehua, Kercher, Timothy, Harris, Roy, Narla, Rama Krishna, Leisten, Jim, Tang, Yang, Moghaddam, Mehran, Ebinger, Katalin, Piccotti, Joseph, Havens, Courtney G, Cathers, Brian, Carmichael, James, Daniel, Thomas, Vessey, Rupert, Hamann, Lawrence G, Leftheris, Katerina, Mendy, Derek, Baculi, Frans, LeBrun, Laurie A, Khambatta, Gody, Lopez-Girona, Antonia
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction
Raman, Malavika, Havens, Courtney G., Walter, Johannes C., Harper, J. Wade
Published in Molecular cell (07.10.2011)
Published in Molecular cell (07.10.2011)
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CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL
Hagner, Patrick R., Man, Hon-Wah, Fontanillo, Celia, Wang, Maria, Couto, Suzana, Breider, Mike, Bjorklund, Chad, Havens, Courtney G., Lu, Gang, Rychak, Emily, Raymon, Heather, Narla, Rama Krishna, Barnes, Leo, Khambatta, Gody, Chiu, Hsiling, Kosek, Jolanta, Kang, Jian, Amantangelo, Michael D., Waldman, Michelle, Lopez-Girona, Antonia, Cai, Ti, Pourdehnad, Michael, Trotter, Matthew, Daniel, Thomas O., Schafer, Peter H., Klippel, Anke, Thakurta, Anjan, Chopra, Rajesh, Gandhi, Anita K.
Published in Blood (06.08.2015)
Published in Blood (06.08.2015)
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Ribonucleotide Reductase Activity Is Coupled to DNA Synthesis via Proliferating Cell Nuclear Antigen
Salguero, Israel, Guarino, Estrella, Shepherd, Marianne E.A., Deegan, Tom D., Havens, Courtney G., MacNeill, Stuart A., Walter, Johannes C., Kearsey, Stephen E.
Published in Current biology (24.04.2012)
Published in Current biology (24.04.2012)
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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)
Gandhi, Anita K, Kang, Jian, Havens, Courtney G, Conklin, Thomas, Ning, Yuhong, Wu, Lei, Ito, Takumi, Ando, Hideki, Waldman, Michelle F, Thakurta, Anjan, Klippel, Anke, Handa, Hiroshi, Daniel, Thomas O, Schafer, Peter H, Chopra, Rajesh
Published in British journal of haematology (01.03.2014)
Published in British journal of haematology (01.03.2014)
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Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2
Havens, Courtney G., Shobnam, Nadia, Guarino, Estrella, Centore, Richard C., Zou, Lee, Kearsey, Stephen E., Walter, Johannes C.
Published in The Journal of biological chemistry (30.03.2012)
Published in The Journal of biological chemistry (30.03.2012)
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CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase
Centore, Richard C, Havens, Courtney G, Manning, Amity L, Li, Ju-Mei, Flynn, Rachel Litman, Tse, Alice, Jin, Jianping, Dyson, Nicholas J, Walter, Johannes C, Zou, Lee
Published in Molecular cell (08.10.2010)
Published in Molecular cell (08.10.2010)
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Thymine DNA Glycosylase Is a CRL4Cdt2 Substrate
Slenn, Tamara J., Morris, Benjamin, Havens, Courtney G., Freeman, Robert M., Takahashi, Tatsuro S., Walter, Johannes C.
Published in The Journal of biological chemistry (15.08.2014)
Published in The Journal of biological chemistry (15.08.2014)
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Journal Article
Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN
Gandhi, Anita K., Kang, Jian, Havens, Courtney G., Conklin, Thomas, Ning, Yuhong, Wu, Lei, Ito, Takumi, Ando, Hideki, Waldman, Michelle F., Thakurta, Anjan, Klippel, Anke, Handa, Hiroshi, Daniel, Thomas O., Schafer, Peter H., Chopra, Rajesh
Published in British journal of haematology (01.03.2014)
Published in British journal of haematology (01.03.2014)
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Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species
Havens, Courtney G., Ho, Alan, Yoshioka, Naohisa, Dowdy, Steven F.
Published in Molecular and Cellular Biology (01.06.2006)
Published in Molecular and Cellular Biology (01.06.2006)
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다발성 골수종의 치료 및 4--3-플루오로벤조니트릴에 대한 바이오마커의 용도
HANSEN JOSHUA, PIERCE DANIEL W, WONG LILLY L, ANTON MARIA SORAYA CARRANCIO, LU GANG, LOPEZ GIRONA ANTONIA, HAVENS COURTNEY G
Year of Publication 05.03.2021
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Year of Publication 05.03.2021
Patent
항증식성 화합물 및 이의 사용 방법
CARMICHAEL JAMES, ALEXANDER MATTHEW D, CARRANCIO SORAYA, CATHERS BRIAN E, CORREA MATTHEW D, WHITEFIELD BRANDON W, LOPEZ GIRONA ANTONIA, BRAY GORDON L, KERCHER TIMOTHY S, ARTMAN GERALD D. III, HANSEN JOSHUA, ZOU NANFEI, PICCOTTI JOSEPH R, NARLA RAMA K, TAVARES GRECO PAULA A, PIERCE DANIEL W, WONG LILLY L, NAGY MARK A, MAN HON WAH, HAVENS COURTNEY G, LU XIAOLING
Year of Publication 11.03.2020
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Year of Publication 11.03.2020
Patent
METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS
HAGNER PATRICK, GANDHI ANITA, HOLLENBACH PAUL, MACBETH KYLE, BREIDER MIKE, COUTO SUZANA STURLINI, TROTTER MATTHEW WILLIAM BURNELL, WANG MARIA YINGLIN, CHOPRA RAJESH, HAVENS COURTNEY G, KLIPPEL ANKE, REN YAN
Year of Publication 29.07.2016
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Year of Publication 29.07.2016
Patent
CC-92480, a Novel Cereblon E3 Ligase Modulator, Is Synergistic with Dexamethasone, Bortezomib, and Daratumumab in Multiple Myeloma
Wong, Lilly, Narla, Rama Krishna, Leisten, Jim, Bauer, Daniel, Groza, Matthew, Gaffney, Bonny, Havens, Courtney G., Choi, Justin, Houston, Jack, Lopez-Girona, Antonia, Hansen, Joshua, Cathers, Brian E., Carmichael, James, Pierce, Daniel W.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells
Lopez-Girona, Antonia, Havens, Courtney G., Lu, Gang, Rychak, Emily, Mendy, Derek, Gaffney, Bonny, Surka, Christine, Lu, Chin-Chun, Matyskiela, Mary, Khambatta, Gody, Wong, Lilly, Hansen, Joshua, Pierce, Daniel W., Cathers, Brian E., Carmichael, James
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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