A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction
Raman, Malavika, Havens, Courtney G., Walter, Johannes C., Harper, J. Wade
Published in Molecular cell (07.10.2011)
Published in Molecular cell (07.10.2011)
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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)
Gandhi, Anita K, Kang, Jian, Havens, Courtney G, Conklin, Thomas, Ning, Yuhong, Wu, Lei, Ito, Takumi, Ando, Hideki, Waldman, Michelle F, Thakurta, Anjan, Klippel, Anke, Handa, Hiroshi, Daniel, Thomas O, Schafer, Peter H, Chopra, Rajesh
Published in British journal of haematology (01.03.2014)
Published in British journal of haematology (01.03.2014)
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CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL
Hagner, Patrick R., Man, Hon-Wah, Fontanillo, Celia, Wang, Maria, Couto, Suzana, Breider, Mike, Bjorklund, Chad, Havens, Courtney G., Lu, Gang, Rychak, Emily, Raymon, Heather, Narla, Rama Krishna, Barnes, Leo, Khambatta, Gody, Chiu, Hsiling, Kosek, Jolanta, Kang, Jian, Amantangelo, Michael D., Waldman, Michelle, Lopez-Girona, Antonia, Cai, Ti, Pourdehnad, Michael, Trotter, Matthew, Daniel, Thomas O., Schafer, Peter H., Klippel, Anke, Thakurta, Anjan, Chopra, Rajesh, Gandhi, Anita K.
Published in Blood (06.08.2015)
Published in Blood (06.08.2015)
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CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase
Centore, Richard C, Havens, Courtney G, Manning, Amity L, Li, Ju-Mei, Flynn, Rachel Litman, Tse, Alice, Jin, Jianping, Dyson, Nicholas J, Walter, Johannes C, Zou, Lee
Published in Molecular cell (08.10.2010)
Published in Molecular cell (08.10.2010)
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Ribonucleotide Reductase Activity Is Coupled to DNA Synthesis via Proliferating Cell Nuclear Antigen
Salguero, Israel, Guarino, Estrella, Shepherd, Marianne E.A., Deegan, Tom D., Havens, Courtney G., MacNeill, Stuart A., Walter, Johannes C., Kearsey, Stephen E.
Published in Current biology (24.04.2012)
Published in Current biology (24.04.2012)
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Thymine DNA Glycosylase Is a CRL4Cdt2 Substrate
Slenn, Tamara J., Morris, Benjamin, Havens, Courtney G., Freeman, Robert M., Takahashi, Tatsuro S., Walter, Johannes C.
Published in The Journal of biological chemistry (15.08.2014)
Published in The Journal of biological chemistry (15.08.2014)
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Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2
Havens, Courtney G., Shobnam, Nadia, Guarino, Estrella, Centore, Richard C., Zou, Lee, Kearsey, Stephen E., Walter, Johannes C.
Published in The Journal of biological chemistry (30.03.2012)
Published in The Journal of biological chemistry (30.03.2012)
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Journal Article
Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN
Gandhi, Anita K., Kang, Jian, Havens, Courtney G., Conklin, Thomas, Ning, Yuhong, Wu, Lei, Ito, Takumi, Ando, Hideki, Waldman, Michelle F., Thakurta, Anjan, Klippel, Anke, Handa, Hiroshi, Daniel, Thomas O., Schafer, Peter H., Chopra, Rajesh
Published in British journal of haematology (01.03.2014)
Published in British journal of haematology (01.03.2014)
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Journal Article
Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species
Havens, Courtney G., Ho, Alan, Yoshioka, Naohisa, Dowdy, Steven F.
Published in Molecular and Cellular Biology (01.06.2006)
Published in Molecular and Cellular Biology (01.06.2006)
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Journal Article
CC-92480, a Novel Cereblon E3 Ligase Modulator, Is Synergistic with Dexamethasone, Bortezomib, and Daratumumab in Multiple Myeloma
Wong, Lilly, Narla, Rama Krishna, Leisten, Jim, Bauer, Daniel, Groza, Matthew, Gaffney, Bonny, Havens, Courtney G., Choi, Justin, Houston, Jack, Lopez-Girona, Antonia, Hansen, Joshua, Cathers, Brian E., Carmichael, James, Pierce, Daniel W.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells
Lopez-Girona, Antonia, Havens, Courtney G., Lu, Gang, Rychak, Emily, Mendy, Derek, Gaffney, Bonny, Surka, Christine, Lu, Chin-Chun, Matyskiela, Mary, Khambatta, Gody, Wong, Lilly, Hansen, Joshua, Pierce, Daniel W., Cathers, Brian E., Carmichael, James
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Abstract 6047: Discovery and characterization of PVTX-321, an estrogen receptor heterobifunctional degrader
Havens, Courtney G., Xu, Guozhang, Lowenstein, Cass, Samanta, Debangshu, Vidal, Brian, Behshad, Elham, Nagilla, Rakesh, Russell, Mike, Orth, Peter, Wu, Winston, Jolivette, Larry, Priestley, Scott, Mohammad, Helai, Sui, Zhihua
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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CC-122 Has Potent Anti-Lymphoma Activity through Destruction of the Aiolos and Ikaros Transcription Factors and Induction of Interferon Response Pathways
Hagner, Patrick, Wang, Maria, Couto, Suzana, Breider, Mike, Fontanillo, Celia, Trotter, Matthew, Bjorklund, Chad C, Havens, Courtney G., Raymon, Heather K, Narla, Rama Krishna, Barnes, Leo, Waldman, Michelle, Daniel, Tom, Klippel, Anke, Pourdehnad, Michael, Thakurta, Anjan, Chopra, Rajesh, Gandhi, Anita K.
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Journal Article
IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance
Havens, Courtney G., Bjorklund, Chad, Kang, Jian, Ortiz, Maria, Fontanillo, Celia, Amatangelo, Michael, Lu, Ling, Neri, Paola E., Lopez-Girona, Antonia, Bahlis, Nizar J., Thakurta, Anjan, Trotter, Mathew, Gandhi, Anita K., Klippel, Anke, Chopra, Rajesh
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs® Immunomodulatory Compounds
Bjorklund, Chad C, Havens, Courtney G., Hagner, Patrick R, Gandhi, Anita K., Wang, Maria, Amatangelo, Michael D, Lu, Ling, Wang, Huisheng, Breider, Mike, Ren, Yan, Lopez-Girona, Antonia, Thakurta, Anjan, Klippel, Anke, Chopra, Rajesh
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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