Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes
Thomas, Melissa K, Nikooienejad, Amir, Bray, Ross, Cui, Xuewei, Wilson, Jonathan, Duffin, Kevin, Milicevic, Zvonko, Haupt, Axel, Robins, Deborah A
Published in The journal of clinical endocrinology and metabolism (01.02.2021)
Published in The journal of clinical endocrinology and metabolism (01.02.2021)
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LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept
Coskun, Tamer, Urva, Shweta, Roell, William C., Qu, Hongchang, Loghin, Corina, Moyers, Julie S., O’Farrell, Libbey S., Briere, Daniel A., Sloop, Kyle W., Thomas, Melissa K., Pirro, Valentina, Wainscott, David B., Willard, Francis S., Abernathy, Matthew, Morford, LaRonda, Du, Yu, Benson, Charles, Gimeno, Ruth E., Haupt, Axel, Milicevic, Zvonko
Published in Cell metabolism (06.09.2022)
Published in Cell metabolism (06.09.2022)
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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept
Coskun, Tamer, Sloop, Kyle W., Loghin, Corina, Alsina-Fernandez, Jorge, Urva, Shweta, Bokvist, Krister B., Cui, Xuewei, Briere, Daniel A., Cabrera, Over, Roell, William C., Kuchibhotla, Uma, Moyers, Julie S., Benson, Charles T., Gimeno, Ruth E., D'Alessio, David A., Haupt, Axel
Published in Molecular metabolism (Germany) (01.12.2018)
Published in Molecular metabolism (Germany) (01.12.2018)
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The novel dual glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 (GLP‐1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long‐acting GLP‐1 receptor agonists
Urva, Shweta, Coskun, Tamer, Loghin, Corina, Cui, Xuewei, Beebe, Emily, O'Farrell, Libbey, Briere, Daniel A., Benson, Charles, Nauck, Michael A., Haupt, Axel
Published in Diabetes, obesity & metabolism (01.10.2020)
Published in Diabetes, obesity & metabolism (01.10.2020)
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Risk of severe hypoglycemia in sulfonylurea-treated patients from diabetes centers in Germany/Austria: How big is the problem? Which patients are at risk?
Schloot, Nanette C., Haupt, Axel, Schütt, Morten, Badenhoop, Klaus, Laimer, Markus, Nicolay, Claudia, Reaney, Matthew, Fink, Katharina, Holl, Reinhard W.
Published in Diabetes/metabolism research and reviews (01.03.2016)
Published in Diabetes/metabolism research and reviews (01.03.2016)
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New improved radiometabolite analysis method for [18F]FTHA from human plasma: a test-retest study with postprandial and fasting state
Aarnio, Richard, Kirjavainen, Anna, Rajander, Johan, Forsback, Sarita, Kalliokoski, Kari, Nuutila, Pirjo, Milicevic, Zvonko, Coskun, Tamer, Haupt, Axel, Laitinen, Iina, Haaparanta-Solin, Merja
Published in EJNMMI research (13.06.2024)
Published in EJNMMI research (13.06.2024)
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Impact of Variation in the FTO Gene on Whole Body Fat Distribution, Ectopic Fat, and Weight Loss
Haupt, Axel, Thamer, Claus, Machann, Jürgen, Kirchhoff, Kerstin, Stefan, Norbert, Tschritter, Otto, Machicao, Fausto, Schick, Fritz, Häring, Hans‐Ulrich, Fritsche, Andreas
Published in Obesity (Silver Spring, Md.) (01.08.2008)
Published in Obesity (Silver Spring, Md.) (01.08.2008)
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Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion
Heni, Martin, Haupt, Axel, Schäfer, Silke A, Ketterer, Caroline, Thamer, Claus, Machicao, Fausto, Stefan, Norbert, Staiger, Harald, Häring, Hans-Ulrich, Fritsche, Andreas
Published in BMC genetics (09.06.2010)
Published in BMC genetics (09.06.2010)
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An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans
Fritsche, Andreas, Häring, Hans-Ulrich, Tschritter, Otto, Machicao, Fausto, Sartorius, Tina, Hennige, Anita M., Haupt, Axel, Preissl, Hubert, Ketterer, Caroline
Published in Journal of Obesity (01.01.2011)
Published in Journal of Obesity (01.01.2011)
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Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA
Rosenstock, Julio, Frias, Juan, Jastreboff, Ania M, Du, Yu, Lou, Jitong, Gurbuz, Sirel, Thomas, Melissa K, Hartman, Mark L, Haupt, Axel, Milicevic, Zvonko, Coskun, Tamer
Published in The Lancet (British edition) (12.08.2023)
Published in The Lancet (British edition) (12.08.2023)
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Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity
Wharton, Sean, Blevins, Thomas, Connery, Lisa, Rosenstock, Julio, Raha, Sohini, Liu, Rong, Ma, Xiaosu, Mather, Kieren J., Haupt, Axel, Robins, Deborah, Pratt, Edward, Kazda, Christof, Konig, Manige
Published in The New England journal of medicine (07.09.2023)
Published in The New England journal of medicine (07.09.2023)
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Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
Jastreboff, Ania M., Kaplan, Lee M., Frías, Juan P., Wu, Qiwei, Du, Yu, Gurbuz, Sirel, Coskun, Tamer, Haupt, Axel, Milicevic, Zvonko, Hartman, Mark L.
Published in The New England journal of medicine (10.08.2023)
Published in The New England journal of medicine (10.08.2023)
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The Effect of Tirzepatide on Food Intake in Humans
Dunn, Julia, Haupt, Axel, Coskun, Tamer, Milicevic, Zvonko
Published in Obesity (Silver Spring, Md.) (01.11.2022)
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Published in Obesity (Silver Spring, Md.) (01.11.2022)
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Effects of Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide on Biomarkers of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes
Hartman, Mark L, Sanyal, Arun J, Loomba, Rohit, Wilson, Jonathan M, Nikooienejad, Amir, Bray, Ross, Karanikas, Chrisanthi A, Duffin, Kevin L, Robins, Deborah A, Haupt, Axel
Published in Diabetes care (01.06.2020)
Published in Diabetes care (01.06.2020)
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Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial
Frias, Juan Pablo, Nauck, Michael A, Van, Joanna, Kutner, Mark E, Cui, Xuewei, Benson, Charles, Urva, Shweta, Gimeno, Ruth E, Milicevic, Zvonko, Robins, Deborah, Haupt, Axel
Published in The Lancet (British edition) (17.11.2018)
Published in The Lancet (British edition) (17.11.2018)
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Journal Article
Association of obesity risk SNPs in PCSK1with insulin sensitivity and proinsulin conversion
Heni, Martin, Haupt, Axel, Schäfer, Silke A, Ketterer, Caroline, Thamer, Claus, Machicao, Fausto, Stefan, Norbert, Staiger, Harald, Häring, Hans-Ulrich, Fritsche, Andreas
Published in BMC medical genetics (09.06.2010)
Published in BMC medical genetics (09.06.2010)
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Efficacy and tolerability of tirzepatide, a dual glucose‐dependent insulinotropic peptide and glucagon‐like peptide‐1 receptor agonist in patients with type 2 diabetes: A 12‐week, randomized, double‐blind, placebo‐controlled study to evaluate different dose‐escalation regimens
Frias, Juan Pablo, Nauck, Michael A., Van, Joanna, Benson, Charles, Bray, Ross, Cui, Xuewei, Milicevic, Zvonko, Urva, Shweta, Haupt, Axel, Robins, Deborah A.
Published in Diabetes, obesity & metabolism (01.06.2020)
Published in Diabetes, obesity & metabolism (01.06.2020)
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