The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
Hatzelmann, Armin, Morcillo, Esteban J, Lungarella, Giuseppe, Adnot, Serge, Sanjar, Shahin, Beume, Rolf, Schudt, Christian, Tenor, Hermann
Published in Pulmonary pharmacology & therapeutics (01.08.2010)
Published in Pulmonary pharmacology & therapeutics (01.08.2010)
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Journal Article
Cytokine-dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition
Selige, Jens, Tenor, Hermann, Hatzelmann, Armin, Dunkern, Torsten
Published in Journal of cellular physiology (01.05.2010)
Published in Journal of cellular physiology (01.05.2010)
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Journal Article
Potent Inhibition of Ca2+ Release-activated Ca2+ Channels and T-lymphocyte Activation by the Pyrazole Derivative BTP2
Zitt, Christof, Strauss, Bettina, Schwarz, Eva C., Spaeth, Nicola, Rast, Georg, Hatzelmann, Armin, Hoth, Markus
Published in The Journal of biological chemistry (26.03.2004)
Published in The Journal of biological chemistry (26.03.2004)
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Journal Article
Phosphodiesterase 2 Mediates Redox-Sensitive Endothelial Cell Proliferation and Angiogenesis by Thrombin via Rac1 and NADPH Oxidase 2
Diebold, Isabel, Djordjevic, Talija, Petry, Andreas, Hatzelmann, Armin, Tenor, Hermann, Hess, John, Görlach, Agnes
Published in Circulation research (22.05.2009)
Published in Circulation research (22.05.2009)
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Journal Article
Effects of Roflumilast, a Phosphodiesterase-4 Inhibitor, on Hypoxia- and Monocrotaline-Induced Pulmonary Hypertension in Rats
Izikki, Mohamed, Raffestin, Bernadette, Klar, Juergen, Hatzelmann, Armin, Marx, Degenhard, Tenor, Hermann, Zadigue, Patricia, Adnot, Serge, Eddahibi, Saadia
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
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Journal Article
In Vitro and in Vivo Anti-Inflammatory Activity of the New Glucocorticoid Ciclesonide
Stoeck, Michael, Riedel, Richard, Hochhaus, Günther, Häfner, Dietrich, Masso, José M, Schmidt, Beate, Hatzelmann, Armin, Marx, Degenhard, Bundschuh, Daniela S
Published in The Journal of pharmacology and experimental therapeutics (01.04.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2004)
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Journal Article
Effects of the soluble guanylyl cyclase activator, YC‐1, on vascular tone, cyclic GMP levels and phosphodiesterase activity
Galle, Jan, Zabel, Ulrike, Hübner, Ulrich, Hatzelmann, Armin, Wagner, Birgit, Wanner, Christoph, Schmidt, Harald H H W
Published in British journal of pharmacology (01.05.1999)
Published in British journal of pharmacology (01.05.1999)
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Journal Article
Pharmacology, clinical efficacy, and tolerability of phosphodiesterase-4 inhibitors: impact of human pharmacokinetics
Tenor, Hermann, Hatzelmann, Armin, Beume, Rolf, Lahu, Gezim, Zech, Karl, Bethke, Thomas D
Published in Handbook of experimental pharmacology (01.01.2011)
Published in Handbook of experimental pharmacology (01.01.2011)
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Journal Article
Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects
Tenor, Hermann, Hatzelmann, Armin, Church, Martin K., Schudt, Christian, Shute, Janis K.
Published in British journal of pharmacology (01.08.1996)
Published in British journal of pharmacology (01.08.1996)
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Journal Article
Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: A comparative study
Gantner, Florian, Tenor, Hermann, Gekeler, Volker, Schudt, Christian, Wendel, Albrecht, Hatzelmann, Armin
Published in Journal of allergy and clinical immunology (01.10.1997)
Published in Journal of allergy and clinical immunology (01.10.1997)
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Journal Article
Characterization of the Phosphodiesterase (PDE) Pattern of in Vitro-Generated Human Dendritic Cells (DC) and the Influence of PDE Inhibitors on DC Function
Gantner, Florian, Schudt, Christian, Wendel, Albrecht, Hatzelmann, Armin
Published in Pulmonary pharmacology & therapeutics (01.12.1999)
Published in Pulmonary pharmacology & therapeutics (01.12.1999)
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Journal Article
Protection from T Cell-Mediated Murine Liver Failure by Phosphodiesterase Inhibitors
Gantner, F, Küsters, S, Wendel, A, Hatzelmann, A, Schudt, C, Tiegs, G
Published in The Journal of pharmacology and experimental therapeutics (01.01.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.01.1997)
Journal Article
Inhibition of TGF-β induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase
Dunkern, Torsten R., Feurstein, Daniel, Rossi, Giovanni A., Sabatini, Federica, Hatzelmann, Armin
Published in European journal of pharmacology (15.10.2007)
Published in European journal of pharmacology (15.10.2007)
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Journal Article
Differential Expression and Function of Phosphodiesterase 4 (PDE4) Subtypes in Human Primary CD4+ T Cells: Predominant Role of PDE4D
Peter, Daniel, Jin, S. L. Catherine, Conti, Marco, Hatzelmann, Armin, Zitt, Christof
Published in The Journal of immunology (1950) (15.04.2007)
Published in The Journal of immunology (1950) (15.04.2007)
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Journal Article
Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells
Dong, Hongli, Zitt, Christof, Auriga, Cornelia, Hatzelmann, Armin, Epstein, Paul M.
Published in Biochemical pharmacology (01.02.2010)
Published in Biochemical pharmacology (01.02.2010)
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Journal Article
Phosphodiesterase inhibitors: history of pharmacology
Schudt, Christian, Hatzelmann, Armin, Beume, Rolf, Tenor, Hermann
Published in Handbook of experimental pharmacology (01.01.2011)
Published in Handbook of experimental pharmacology (01.01.2011)
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Journal Article
Tumor necrosis factor-α–dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability
Seybold, Joachim, Thomas, Dirk, Witzenrath, Martin, Boral, Şengül, Hocke, Andreas C., Bürger, Alexander, Hatzelmann, Armin, Tenor, Hermann, Schudt, Christian, Krüll, Matthias, Schütte, Hartwig, Hippenstiel, Stefan, Suttorp, Norbert
Published in Blood (01.05.2005)
Published in Blood (01.05.2005)
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