Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors
Dumas, Jacques, Brittelli, David, Chen, Jinshan, Dixon, Brian, Hatoum-Mokdad, Holia, König, Gerhard, Sibley, Robert, Witowsky, James, Wong, Stephen
Published in Bioorganic & medicinal chemistry letters (06.09.1999)
Published in Bioorganic & medicinal chemistry letters (06.09.1999)
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Photoredox Catalysis: 1,4-Conjugate Addition of N‑Methyl Radicals to Electron-Deficient Olefins via Decarboxylation of N‑Substituted Acetic Acids
Gingipalli, Lakshmaiah, Boerth, Jeffrey, Emmons, David, Grebe, Tyler, Hatoum-Mokdad, Holia, Peng, Bo, Sha, Li, Tentarelli, Sharon, Wang, Haixia, Wu, Ye, Zheng, XiaoLan, Edmondson, Scott, Gopalsamy, Ariamala
Published in Organic letters (01.05.2020)
Published in Organic letters (01.05.2020)
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Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists
Scott, James S., Stead, Darren, Barlaam, Bernard, Breed, Jason, Carbajo, Rodrigo J., Chiarparin, Elisabetta, Cureton, Natalie, Davey, Paul R. J., Fisher, David I., Gangl, Eric T., Grebe, Tyler, Greenwood, Ryan D., Hande, Sudhir, Hatoum-Mokdad, Holia, Hughes, Samantha J., Hunt, Thomas A., Johnson, Tony, Kavanagh, Stefan L., Klinowska, Teresa C. M., Larner, Carrie J. B., Lawson, Mandy, Lister, Andrew S., Longmire, David, Marden, Stacey, McGuire, Thomas M., McMillan, Caroline, McMurray, Lindsay, Morrow, Christopher J., Nissink, J. Willem M., Moss, Thomas A., O’Donovan, Daniel H., Polanski, Radoslaw, Stokes, Stephen, Thakur, Kumar, Trueman, Dawn, Truman, Caroline, Tucker, Michael J., Wang, Haixia, Whalley, Nicky, Wu, Dedong, Wu, Ye, Yang, Bin, Yang, Wenzhan
Published in Journal of medicinal chemistry (23.02.2023)
Published in Journal of medicinal chemistry (23.02.2023)
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Journal Article
Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833
Scott, James S, Moss, Thomas A, Barlaam, Bernard, Davey, Paul R. J, Fairley, Gary, Gangl, Eric T, Greenwood, Ryan D. R, Hatoum-Mokdad, Holia, Lister, Andrew S, Longmire, David, Polanski, Radoslaw, Stokes, Stephen, Tucker, Michael J, Varnes, Jeffrey G, Yang, Bin
Published in ACS medicinal chemistry letters (10.12.2020)
Published in ACS medicinal chemistry letters (10.12.2020)
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Discovery of Efficacious Pseudomonas aeruginosa-Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-mechanistic Pharmacokinetic/Pharmacodynamic Model
Murphy-Benenato, Kerry E, Bhagunde, Pratik R, Chen, April, Davis, Hajnalka E, Durand-Réville, Thomas F, Ehmann, David E, Galullo, Vincent, Harris, Jennifer J, Hatoum-Mokdad, Holia, Jahić, Haris, Kim, Aryun, Manjunatha, M. R, Manyak, Erika L, Mueller, John, Patey, Sara, Quiroga, Olga, Rooney, Michael, Sha, Li, Shapiro, Adam B, Sylvester, Mark, Tan, Beesan, Tsai, Andy S, Uria-Nickelsen, Maria, Wu, Ye, Zambrowski, Mark, Zhao, Shannon X
Published in Journal of medicinal chemistry (12.03.2015)
Published in Journal of medicinal chemistry (12.03.2015)
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Journal Article
BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS
LEE WENDY, ZHANG CHENGZHI, HATOUM MOKDAD HOLIA, BURKE MICHAEL, FAN JIANMEI, CHEN ZHI, JONES BENJAMIN D, DUMAS JACQUES, FAN DONGPING, LADOUCEUR GAETAN, PHILLIPS BARTON
Year of Publication 16.03.2010
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Year of Publication 16.03.2010
Patent
A Novel Estrogen Receptor Ligand Template
Sibley, Robert, Hatoum-Mokdad, Holia, Schoenleber, Robert, Musza, Laszlo, Stirtan, William, Marrero, Diana, Carley, William, Xiao, Hong, Dumas, Jacques
Published in ChemInform (09.09.2003)
Published in ChemInform (09.09.2003)
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Journal Article
A novel estrogen receptor ligand template
Sibley, Robert, Hatoum-Mokdad, Holia, Schoenleber, Robert, Musza, Laszlo, Stirtan, William, Marrero, Diana, Carley, William, Xiao, Hong, Dumas, Jacques
Published in Bioorganic & medicinal chemistry letters (02.06.2003)
Published in Bioorganic & medicinal chemistry letters (02.06.2003)
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Journal Article
1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors
Dumas, Jacques, Hatoum-Mokdad, Holia, Sibley, Robert, Riedl, Bernd, Scott, William J, Monahan, Mary Katherine, Lowinger, Timothy B, Brennan, Catherine, Natero, Reina, Turner, Tiffany, Johnson, Jeffrey S, Schoenleber, Robert, Bhargava, Ajay, Wilhelm, Scott M, Housley, Timothy J, Ranges, Gerald E, Shrikhande, Alka
Published in Bioorganic & medicinal chemistry letters (18.09.2000)
Published in Bioorganic & medicinal chemistry letters (18.09.2000)
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Journal Article
Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor
Dumas, Jacques, Hatoum-Mokdad, Holia, Sibley, Robert N, Smith, Roger A, Scott, William J, Khire, Uday, Lee, Wendy, Wood, Jill, Wolanin, Donald, Cooley, Jeffrey, Bankston, Donald, Redman, Aniko M, Schoenleber, Robert, Caringal, Yolanda, Gunn, David, Romero, Romulo, Osterhout, Martin, Paulsen, Holger, Housley, Timothy J, Wilhelm, Scott M, Pirro, John, Chien, Du-Shieng, Ranges, Gerald E, Shrikhande, Alka, Muzsi, Andrew, Bortolon, Elizabeth, Wakefield, Jean, Gianpaolo Ostravage, Cynthia, Bhargava, Ajay, Chau, Thuy
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
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Journal Article
RHO-KINASE INHIBITORS
PLUEMPE HANS, NAGARAHNAM DHANAPALAN, BOYER STEPHEN, DUMAS JACQUES, HATOUM-MOKDAD HOLIA
Year of Publication 29.11.2012
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Year of Publication 29.11.2012
Patent
PYRIMIDINE DERIVATIVES AS RHO-KINASE INHIBITORS
DUMAS, JACQUES, BENNABI, SAMIR, NAGARATHNAM, DHANAPALAN, PLUEMPE, HANS, FEURER, ACHIM, WANG, CHUNGUANG, HATOUM-MOKDAD, HOLIA, BOYER, STEPHEN
Year of Publication 11.07.2012
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Year of Publication 11.07.2012
Patent
PYRIMIDINE DERIVATIVES AS RHO-KINASE INHIBITORS
DUMAS, JACQUES, NAGARATHNAM, DHANAPALAN, PLUEMPE, HANS, HATOUM-MOKDAD, HOLIA, BOYER, STEPHEN
Year of Publication 15.03.2011
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Year of Publication 15.03.2011
Patent
Rho-Kinase Inhibitors
PLUEMPE HANS, BOYER STEPHEN, WANG CHUNGUANG, NAGARATHNAM DHANAPALAN, FEURER ACHIM, DUMAS JACQUES, HATOUM-MOKDAD HOLIA, BENNABI SAMIR
Year of Publication 01.03.2012
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Year of Publication 01.03.2012
Patent
SUBSTITUTED PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER
DUMAS, JACQUES, LADOUCEUR, GAETAN, SMITH, ROGER, CHEN, ZHI, LIU, QINGJIE, LEE, WENDY, MOKDAD, HOLIA, HATOUM, WANG, GAN, YING, SHIHONG
Year of Publication 27.07.2011
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Year of Publication 27.07.2011
Patent
Substituted Pyrazolyl Urea Derivatives Useful In The Treatment Of Cancer
LEE WENDY, LIU QINGJIE, CHEN ZHI, WANG GAN, LADOUCEUR GAETAN, DUMAS JACQUES, SMITH ROGER, YING SHIHONG, MOKDAD HOLIA HATOUM
Year of Publication 09.06.2011
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Year of Publication 09.06.2011
Patent
Substituted pyrazolyl urea derivatives useful in the treatment of cancer
DUMAS, JACQUES, LADOUCEUR, GAETAN, SMITH, ROGER, MOKDAD, HOLIA HATOUM, CHEN, ZHI, LIU, QINGJIE, LEE, WENDY, WANG, GAN, YING, SHIHONG
Year of Publication 16.03.2011
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Year of Publication 16.03.2011
Patent
Substituted pyrazolyl urea derivatives useful in the treatment of cancer
DUMAS, JACQUES, LADOUCEUR, GAETAN, SMITH, ROGER, MOKDAD, HOLIA HATOUM, CHEN, ZHI, LIU, QINGJIE, LEE, WENDY, WANG, GAN, YING, SHIHONG
Year of Publication 16.03.2011
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Year of Publication 16.03.2011
Patent
Substituted pyrazolyl urea derivatives useful in the treatment of cancer
Lee, Wendy, Ladouceur, Gaetan, Dumas, Jacques, Smith, Roger, Ying, Shihong, Wang, Gan, Chen, Zhi, Liu, Qingjie, Mokdad, Holia Hatoum
Year of Publication 23.11.2010
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Year of Publication 23.11.2010
Patent