Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation
Tanaka, Noritaka, Lin, Jessica J., Li, Chendi, Ryan, Meagan B., Zhang, Junbing, Kiedrowski, Lesli A., Michel, Alexa G., Syed, Mohammed U., Fella, Katerina A., Sakhi, Mustafa, Baiev, Islam, Juric, Dejan, Gainor, Justin F., Klempner, Samuel J., Lennerz, Jochen K., Siravegna, Giulia, Bar-Peled, Liron, Hata, Aaron N., Heist, Rebecca S., Corcoran, Ryan B.
Published in Cancer discovery (01.08.2021)
Published in Cancer discovery (01.08.2021)
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Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer
Raoof, Sana, Mulford, Iain J, Frisco-Cabanos, Heidie, Nangia, Varuna, Timonina, Daria, Labrot, Emma, Hafeez, Nafeeza, Bilton, Samantha J, Drier, Yotam, Ji, Fei, Greenberg, Max, Williams, August, Kattermann, Krystina, Damon, Leah, Sovath, Sosathya, Rakiec, Daniel P, Korn, Joshua M, Ruddy, David A, Benes, Cyril H, Hammerman, Peter S, Piotrowska, Zofia, Sequist, Lecia V, Niederst, Matthew J, Barretina, Jordi, Engelman, Jeffrey A, Hata, Aaron N
Published in Oncogene (01.09.2019)
Published in Oncogene (01.09.2019)
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Impact of EML4-ALK Variant on Resistance Mechanisms and Clinical Outcomes in ALK-Positive Lung Cancer
Lin, Jessica J, Zhu, Viola W, Yoda, Satoshi, Yeap, Beow Y, Schrock, Alexa B, Dagogo-Jack, Ibiayi, Jessop, Nicholas A, Jiang, Ginger Y, Le, Long P, Gowen, Kyle, Stephens, Philip J, Ross, Jeffrey S, Ali, Siraj M, Miller, Vincent A, Johnson, Melissa L, Lovly, Christine M, Hata, Aaron N, Gainor, Justin F, Iafrate, Anthony J, Shaw, Alice T, Ou, Sai-Hong Ignatius
Published in Journal of clinical oncology (20.04.2018)
Published in Journal of clinical oncology (20.04.2018)
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The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models
Katayama, Ryohei, Gong, Bo, Togashi, Noriko, Miyamoto, Masaya, Kiga, Masaki, Iwasaki, Shiho, Kamai, Yasuki, Tominaga, Yuichi, Takeda, Yasuyuki, Kagoshima, Yoshiko, Shimizu, Yuki, Seto, Yosuke, Oh-Hara, Tomoko, Koike, Sumie, Nakao, Naoki, Hanzawa, Hiroyuki, Watanabe, Kengo, Yoda, Satoshi, Yanagitani, Noriko, Hata, Aaron N, Shaw, Alice T, Nishio, Makoto, Fujita, Naoya, Isoyama, Takeshi
Published in Nature communications (09.08.2019)
Published in Nature communications (09.08.2019)
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MET Alterations Are a Recurring and Actionable Resistance Mechanism in ALK-Positive Lung Cancer
Dagogo-Jack, Ibiayi, Yoda, Satoshi, Lennerz, Jochen K, Langenbucher, Adam, Lin, Jessica J, Rooney, Marguerite M, Prutisto-Chang, Kylie, Oh, Audris, Adams, Nathaniel A, Yeap, Beow Y, Chin, Emily, Do, Andrew, Marble, Hetal D, Stevens, Sara E, Digumarthy, Subba R, Saxena, Ashish, Nagy, Rebecca J, Benes, Cyril H, Azzoli, Christopher G, Lawrence, Michael S, Gainor, Justin F, Shaw, Alice T, Hata, Aaron N
Published in Clinical cancer research (01.06.2020)
Published in Clinical cancer research (01.06.2020)
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Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models
Corcoran, Ryan B., Cheng, Katherine A., Hata, Aaron N., Faber, Anthony C., Ebi, Hiromichi, Coffee, Erin M., Greninger, Patricia, Brown, Ronald D., Godfrey, Jason T., Cohoon, Travis J., Song, Youngchul, Lifshits, Eugene, Hung, Kenneth E., Shioda, Toshi, Dias-Santagata, Dora, Singh, Anurag, Settleman, Jeffrey, Benes, Cyril H., Mino-Kenudson, Mari, Wong, Kwok-Kin, Engelman, Jeffrey A.
Published in Cancer cell (14.01.2013)
Published in Cancer cell (14.01.2013)
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Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity
Marcar, Lynnette, Bardhan, Kankana, Gheorghiu, Liliana, Dinkelborg, Patrick, Pfäffle, Heike, Liu, Qi, Wang, Meng, Piotrowska, Zofia, Sequist, Lecia V., Borgmann, Kerstin, Settleman, Jeffrey E., Engelman, Jeffrey A., Hata, Aaron N., Willers, Henning
Published in Cell reports (Cambridge) (18.06.2019)
Published in Cell reports (Cambridge) (18.06.2019)
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Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information
Heather, James M, Spindler, Matthew J, Alonso, Marta Herrero, Shui, Yifang Ivana, Millar, David G, Johnson, David S, Cobbold, Mark, Hata, Aaron N
Published in Nucleic acids research (08.07.2022)
Published in Nucleic acids research (08.07.2022)
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Cotargeting a MYC/eIF4A-survival axis improves the efficacy of KRAS inhibitors in lung cancer
Nardi, Francesca, Perurena, Naiara, Schade, Amy E, Li, Ze-Hua, Ngo, Kenneth, Ivanova, Elena V, Saldanha, Aisha, Li, Chendi, Gokhale, Prafulla C, Hata, Aaron N, Barbie, David A, Paweletz, Cloud P, Jänne, Pasi A, Cichowski, Karen
Published in The Journal of clinical investigation (15.08.2023)
Published in The Journal of clinical investigation (15.08.2023)
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Patterns of Metastatic Spread and Mechanisms of Resistance to Crizotinib in ROS1 -Positive Non-Small-Cell Lung Cancer
Gainor, Justin F, Tseng, Diane, Yoda, Satoshi, Dagogo-Jack, Ibiayi, Friboulet, Luc, Lin, Jessica J, Hubbeling, Harper G, Dardaei, Leila, Farago, Anna F, Schultz, Katherine R, Ferris, Lorin A, Piotrowska, Zofia, Hardwick, James, Huang, Donghui, Mino-Kenudson, Mari, Iafrate, A John, Hata, Aaron N, Yeap, Beow Y, Shaw, Alice T
Published in JCO precision oncology (01.01.2017)
Published in JCO precision oncology (01.01.2017)
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Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics
Fraser, Cameron S, Spetz, Johan K E, Qin, Xingping, Presser, Adam, Choiniere, Jonathan, Li, Chendi, Yu, Stacey, Blevins, Frances, Hata, Aaron N, Miller, Jeffrey W, Bradshaw, Gary A, Kalocsay, Marian, Sanchorawala, Vaishali, Sarosiek, Shayna, Sarosiek, Kristopher A
Published in Nature communications (02.10.2022)
Published in Nature communications (02.10.2022)
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Increased synthesis of MCL-1 protein underlies initial survival of EGFR mutant lung cancer to EGFR inhibitors and provides a novel drug target
Song, Kyung-A, Hosono, Yasuyuki, Turner, Crystal, Jacob, Sheeba, Lochmann, Timothy L, Murakami, Yoshiko, Patel, Neha U, Ham, Jungoh, Hu, Bin, Powell, Krista M, Coon, Colin M, Windle, Brad, Oya, Yuko, Koblinski, Jennifer E, Harada, Hisashi, Leverson, Joel D, Souers, Andrew J, Hata, Aaron N, Boikos, Sosipatros A, Yatabe, Yasushi, Ebi, Hiromichi, Faber, Anthony C
Published in Clinical cancer research (15.11.2018)
Published in Clinical cancer research (15.11.2018)
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Mitochondria- and caspase-dependent cell death pathway involved in neuronal degeneration in diabetic retinopathy
Oshitari, T, Yamamoto, S, Hata, N, Roy, S
Published in British journal of ophthalmology (01.04.2008)
Published in British journal of ophthalmology (01.04.2008)
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Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers
HATA, Aaron N, YEO, Alan, MINO-KENUDSON, Mari, WONG, Kwok-Kin, ENGELMAN, Jeffrey A, FABER, Anthony C, LIFSHITS, Eugene, ZHAO CHEN, CHENG, Katherine A, WALTON, Zandra, SAROSIEK, Kristopher A, LETAI, Anthony, HEIST, Rebecca S
Published in Cancer research (Chicago, Ill.) (01.06.2014)
Published in Cancer research (Chicago, Ill.) (01.06.2014)
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Intravoxel Incoherent Motion MR Imaging of Pediatric Intracranial Tumors: Correlation with Histology and Diagnostic Utility
Kikuchi, K, Hiwatashi, A, Togao, O, Yamashita, K, Kamei, R, Momosaka, D, Hata, N, Iihara, K, Suzuki, S O, Iwaki, T, Honda, H
Published in American journal of neuroradiology : AJNR (01.05.2019)
Published in American journal of neuroradiology : AJNR (01.05.2019)
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