Discovery and in vitro and in vivo profiles of 4-fluoro- N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]- N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist
Satoh, Atsushi, Nagatomi, Yasushi, Hirata, Yukari, Ito, Satoru, Suzuki, Gentaroh, Kimura, Toshifumi, Maehara, Shunsuke, Hikichi, Hirohiko, Satow, Akio, Hata, Mikiko, Ohta, Hisashi, Kawamoto, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: A potential treatment for psychotic disorders
Ito, Satoru, Hirata, Yukari, Nagatomi, Yasushi, Satoh, Atsushi, Suzuki, Gentaroh, Kimura, Toshifumi, Satow, Akio, Maehara, Shunsuke, Hikichi, Hirohiko, Hata, Mikiko, Ohta, Hisashi, Kawamoto, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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Unique Antipsychotic Activities of the Selective Metabotropic Glutamate Receptor 1 Allosteric Antagonist 2-Cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one
Satow, Akio, Suzuki, Gentaroh, Maehara, Shunsuke, Hikichi, Hirohiko, Murai, Takeshi, Murai, Takashi, Kawagoe-Takaki, Hiroko, Hata, Mikiko, Ito, Satoru, Ozaki, Satoshi, Kawamoto, Hiroshi, Ohta, Hisashi
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
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Pharmacological Characterization of a New, Orally Active and Potent Allosteric Metabotropic Glutamate Receptor 1 Antagonist, 4-[1-(2-Fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC)
Suzuki, Gentaroh, Kimura, Toshifumi, Satow, Akio, Kaneko, Naoki, Fukuda, Junko, Hikichi, Hirohiko, Sakai, Naoko, Maehara, Shunsuke, Kawagoe-Takaki, Hiroko, Hata, Mikiko, Azuma, Tomoko, Ito, Satoru, Kawamoto, Hiroshi, Ohta, Hisashi
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
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Correlation of Receptor Occupancy of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Mouse Brain With In vivo Activity of Allosteric mGluR1 Antagonists
Suzuki, Gentaroh, Kawagoe-Takaki, Hiroko, Inoue, Takao, Kimura, Toshifumi, Hikichi, Hirohiko, Murai, Takashi, Satow, Akio, Hata, Mikiko, Maehara, Shunsuke, Ito, Satoru, Kawamoto, Hiroshi, Ozaki, Satoshi, Ohta, Hisashi
Published in Journal of Pharmacological Sciences (2009)
Published in Journal of Pharmacological Sciences (2009)
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A Typical Y1 Receptor Regulates Feeding Behaviors: Effects of a Potent and Selective Y1 Antagonist, J-115814
Kanatani, A, Hata, M, Mashiko, S, Ishihara, A, Okamoto, O, Haga, Y, Ohe, T, Kanno, T, Murai, N, Ishii, Y, Fukuroda, T, Fukami, T, Ihara, M
Published in Molecular pharmacology (01.03.2001)
Published in Molecular pharmacology (01.03.2001)
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EFFECT OF P-GLYCOPROTEIN-MEDIATED EFFLUX ON CEREBROSPINAL FLUID/PLASMA CONCENTRATION RATIO
OHE, Tomoyuki, SATO, Masahiko, ISHII, Yasuyuki, TANAKA, Sachiko, FUJINO, Naoko, HATA, Mikiko, SHIBATA, Yoshihiro, KANATANI, Akio, FUKAMI, Takehiro, YAMAZAKI, Masayo, CHIBA, Masato
Published in Drug metabolism and disposition (01.10.2003)
Published in Drug metabolism and disposition (01.10.2003)
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Blockade of body weight gain and plasma corticosterone levels in Zucker fatty rats using an orally active neuropeptide Y Y1 antagonist
Ishihara, Akane, Kanatani, Akio, Okada, Megumu, Hidaka, Masayasu, Tanaka, Takeshi, Mashiko, Satoshi, Gomori, Akira, Kanno, Tetsuya, Hata, Mikiko, Kanesaka, Maki, Tominaga, Yushin, Sato, Naga‐aki, Kobayashi, Masahiko, Murai, Takashi, Watanabe, Keiko, Ishii, Yasuyuki, Fukuroda, Takahiro, Fukami, Takehiro, Ihara, Masaki
Published in British journal of pharmacology (01.06.2002)
Published in British journal of pharmacology (01.06.2002)
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Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5- c]pyridin-4(5 H)-one (MMPIP), on the central nervous system in rodents
Hikichi, Hirohiko, Murai, Takeshi, Okuda, Shoki, Maehara, Shunsuke, Satow, Akio, Ise, Satoko, Nishino, Miho, Suzuki, Gentaroh, Takehana, Hiroshi, Hata, Mikiko, Ohta, Hisashi
Published in European journal of pharmacology (10.08.2010)
Published in European journal of pharmacology (10.08.2010)
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Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist
Ito, Satoru, Satoh, Atsushi, Nagatomi, Yasushi, Hirata, Yukari, Suzuki, Gentaroh, Kimura, Toshifumi, Satow, Akio, Maehara, Shunsuke, Hikichi, Hirohiko, Hata, Mikiko, Kawamoto, Hiroshi, Ohta, Hisashi
Published in Bioorganic & medicinal chemistry (15.11.2008)
Published in Bioorganic & medicinal chemistry (15.11.2008)
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N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: The first orexin-2 receptor selective non-peptidic antagonist
HIROSE, Masaaki, EGASHIRA, Shin-Ichiro, GOTO, Yasuhiro, HASHIHAYATA, Takashi, OHTAKE, Norikazu, IWAASA, Hisashi, HATA, Mikiko, FUKAMI, Takehiro, KANATANI, Akio, YAMADA, Koji
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5-c]pyridin-4(5H)-one (MMPIP), on the central nervous system in rodents: Metabotropic Glutamate Receptors and Cognition
HIKICHI, Hirohiko, MURAI, Takeshi, OHTA, Hisashi, OKUDA, Shoki, MAEHARA, Shunsuke, SATOW, Akio, ISE, Satoko, NISHINO, Miho, SUZUKI, Gentaroh, TAKEHANA, Hiroshi, HATA, Mikiko
Published in European journal of pharmacology (2010)
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Published in European journal of pharmacology (2010)
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Unique Antipsychotic Activities of the Selective Metabotropic Glutamate Receptor 1 Allosteric Antagonist 2-Cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1 H -1,2,3-triazol-4-yl]-2,3-dihydro-1 H -isoindol-1-one
Satow, Akio, Suzuki, Gentaroh, Maehara, Shunsuke, Hikichi, Hirohiko, Murai, Takeshi, Murai, Takashi, Kawagoe-Takaki, Hiroko, Hata, Mikiko, Ito, Satoru, Ozaki, Satoshi, Kawamoto, Hiroshi, Ohta, Hisashi
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
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The Novel Neuropeptide Y Y1 Receptor Antagonist J-104870: A Potent Feeding Suppressant with Oral Bioavailability
Kanatani, Akio, Kanno, Tetsuya, Ishihara, Akane, Hata, Mikiko, Sakuraba, Aya, Tanaka, Takeshi, Tsuchiya, Yoshimi, Mase, Toshiaki, Fukuroda, Takahiro, Fukami, Takehiro, Ihara, Masaki
Published in Biochemical and biophysical research communications (09.12.1999)
Published in Biochemical and biophysical research communications (09.12.1999)
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Thrombotic microangiopathy-like disorder after living-donor liver transplantation：A single-center experience in Japan
Hori, Tomohide, Kaido, Toshimi, Oike, Fumitaka, Ogura, Yasuhiro, Ogawa, Kohei, Yonekawa, Yukihide, Hata, Koichiro, Kawaguchi, Yoshiya, Ueda, Mikiko, Mori, Akira, Segawa, Hajime, Yurugi, Kimiko, Takada, Yasutsugu, Egawa, Hiroto, Yoshizawa, Atsushi, Kato, Takuma, Saito, Kanako, Wang, Linan, Torii, Mie, Chen, Feng, Baine, Ann-Marie T, Gardner, Lindsay B, Uemoto, Shinji
Published in World journal of gastroenterology : WJG (14.04.2011)
Published in World journal of gastroenterology : WJG (14.04.2011)
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