Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironment in SCLC
Sen, Triparna, Della Corte, Carminia M., Milutinovic, Snezana, Cardnell, Robert J., Diao, Lixia, Ramkumar, Kavya, Gay, Carl M., Stewart, C. Allison, Fan, Youhong, Shen, Li, Hansen, Ryan J., Strouse, Bryan, Hedrick, Michael P., Hassig, Christian A., Heymach, John V., Wang, Jing, Byers, Lauren A.
Published in Journal of thoracic oncology (01.12.2019)
Published in Journal of thoracic oncology (01.12.2019)
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Evidence That the DNA Endonuclease ARTEMIS also Has Intrinsic 5′-Exonuclease Activity
Li, Sicong, Chang, Howard H., Niewolik, Doris, Hedrick, Michael P., Pinkerton, Anthony B., Hassig, Christian A., Schwarz, Klaus, Lieber, Michael R.
Published in The Journal of biological chemistry (14.03.2014)
Published in The Journal of biological chemistry (14.03.2014)
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Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth
Iizuka, Shinji, Quintavalle, Manuela, Navarro, Jose C, Gribbin, Kyle P, Ardecky, Robert J, Abelman, Matthew M, Ma, Chen-Ting, Sergienko, Eduard, Zeng, Fu-Yue, Pass, Ian, Thomas, George V, McWeeney, Shannon K, Hassig, Christian A, Pinkerton, Anthony B, Courtneidge, Sara A
Published in Cancer research (Chicago, Ill.) (15.03.2021)
Published in Cancer research (Chicago, Ill.) (15.03.2021)
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Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML)
Milutinovic, Snezana, Heynen-Genel, Susanne, Chao, Elizabeth, Dewing, Antimone, Solano, Ricardo, Milan, Loribelle, Barron, Nikki, He, Min, Diaz, Paul W, Matsuzawa, Shu-ichi, Reed, John C, Hassig, Christian A
Published in PloS one (31.03.2016)
Published in PloS one (31.03.2016)
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SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex
Feng, Yongmei, Pinkerton, Anthony B, Hulea, Laura, Zhang, Tongwu, Davies, Michael A, Grotegut, Stefan, Cheli, Yann, Yin, Hongwei, Lau, Eric, Kim, Hyungsoo, De, Surya K, Barile, Elisa, Pellecchia, Maurizio, Bosenberg, Marcus, Li, Jian-Liang, James, Brian, Hassig, Christian A, Brown, Kevin M, Topisirovic, Ivan, Ronai, Ze'ev A
Published in Cancer research (Chicago, Ill.) (15.12.2015)
Published in Cancer research (Chicago, Ill.) (15.12.2015)
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Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) Part 2: Identification of a Novel, Potent, and Selective Series of Benzimidazole-Quinolinone iNOS/nNOS Dimerization Inhibitors That Are Orally Active in Pain Models
Payne, Joseph E, Bonnefous, Céline, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D
Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
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Inhibition of Melanoma Growth by Small Molecules That Promote the Mitochondrial Localization of ATF2
VARSANO, Tal, LAU, Eric, YONGMEI FENG, GARRIDO, Marine, MILAN, Loribelle, HEYNEN-GENEL, Susanne, HASSIG, Christian A, RONAI, Ze'ev A
Published in Clinical cancer research (15.05.2013)
Published in Clinical cancer research (15.05.2013)
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Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase
Nagy, Laszlo, Kao, Hung-Ying, Chakravarti, Debabrata, Lin, Richard J, Hassig, Christian A, Ayer, Donald E, Schreiber, Stuart L, Evans, Ronald M
Published in Cell (02.05.1997)
Published in Cell (02.05.1997)
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CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer
Xu, Haineng, Gitto, Sarah B., Ho, Gwo-Yaw, Medvedev, Sergey, Shield-Artin, Kristy, Kim, Hyoung, Beard, Sally, Kinose, Yasuto, Wang, Xiaolei, Barker, Holly E., Ratnayake, Gayanie, Hwang, Wei-Ting, Hansen, Ryan J., Strouse, Bryan, Milutinovic, Snezana, Hassig, Christian, Wakefield, Matthew J., Vandenberg, Cassandra J., Scott, Clare L., Simpkins, Fiona
Published in iScience (19.07.2024)
Published in iScience (19.07.2024)
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Journal Article
Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A
Hassig, Christian A, Fleischer, Tracey C, Billin, Andrew N, Schreiber, Stuart L, Ayer, Donald E
Published in Cell (02.05.1997)
Published in Cell (02.05.1997)
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KD5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by DNA damage and mitochondrial signaling
Feng, Rentian, Ma, Huihui, Hassig, Christian A, Payne, Joseph E, Smith, Nicholas D, Mapara, Markus Y, Hager, Jeffrey H, Lentzsch, Suzanne
Published in Molecular cancer therapeutics (01.06.2008)
Published in Molecular cancer therapeutics (01.06.2008)
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Journal Article
Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs
Hassig, Christian A, Schreiber, Stuart L
Published in Current opinion in chemical biology (01.10.1997)
Published in Current opinion in chemical biology (01.10.1997)
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Journal Article
Discovery of Inducible Nitric Oxide Synthase (iNOS) Inhibitor Development Candidate KD7332, Part 1: Identification of a Novel, Potent, and Selective Series of Quinolinone iNOS Dimerization Inhibitors that are Orally Active in Rodent Pain Models
Bonnefous, Céline, Payne, Joseph E, Roppe, Jeffrey, Zhuang, Hui, Chen, Xiaohong, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Severance, Daniel, Walsh, John P, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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Journal Article
Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex
Schreiber, Stuart L, Tong, Jeffrey K, Hassig, Christian A, Schnitzler, Gavin R, Kingston, Robert E
Published in Nature (London) (29.10.1998)
Published in Nature (London) (29.10.1998)
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Journal Article
Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1
Rong, Juan, Pass, Ian, Diaz, Paul W, Ngo, Tram A, Sauer, Michelle, Magnuson, Gavin, Zeng, Fu-Yue, Hassig, Christian A, Jackson, Michael R, Cosford, Nicholas D P, Matsuzawa, Shu-Ichi, Reed, John C
Published in Journal of biomolecular screening (01.12.2015)
Published in Journal of biomolecular screening (01.12.2015)
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Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins
Hassig, Christian A, Zeng, Fu-Yue, Kung, Paul, Kiankarimi, Mehrak, Kim, Sylvia, Diaz, Paul W, Zhai, Dayong, Welsh, Kate, Morshedian, Shana, Su, Ying, O'Keefe, Barry, Newman, David J, Rusman, Yudi, Kaur, Harneet, Salomon, Christine E, Brown, Susan G, Baire, Beeraiah, Michel, Andrew R, Hoye, Thomas R, Francis, Subhashree, Georg, Gunda I, Walters, Michael A, Divlianska, Daniela B, Roth, Gregory P, Wright, Amy E, Reed, John C
Published in Journal of biomolecular screening (01.09.2014)
Published in Journal of biomolecular screening (01.09.2014)
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Journal Article
A Role for Histone Deacetylase Activity in HDAC1-Mediated Transcriptional Repression
Hassig, Christian A., Tong, Jeffrey K., Fleischer, Tracey C., Owa, Takashi, Grable, Phyllis G., Ayer, Donald E., Schreiber, Stuart L.
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.1998)
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Journal Article
Depudecin Induces Morphological Reversion of Transformed Fibroblasts via the Inhibition of Histone Deacetylase
Kwon, Ho Jeong, Owa, Takashi, Hassig, Christian A., Shimada, Junichi, Schreiber, Stuart L.
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.1998)
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