Translating IL-6 biology into effective treatments
Choy, Ernest H., De Benedetti, Fabrizio, Takeuchi, Tsutomu, Hashizume, Misato, John, Markus R., Kishimoto, Tadamitsu
Published in Nature reviews. Rheumatology (01.06.2020)
Published in Nature reviews. Rheumatology (01.06.2020)
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Journal Article
IL-6/IL-6 receptor system and its role in physiological and pathological conditions
MIHARA, Masahiko, HASHIZUME, Misato, YOSHIDA, Hiroto, SUZUKI, Miho, SHIINA, Masashi
Published in Clinical science (1979) (01.02.2012)
Published in Clinical science (1979) (01.02.2012)
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Journal Article
A phase 2 study of polatuzumab vedotin + bendamustine + rituximab in relapsed/refractory diffuse large B‐cell lymphoma
Terui, Yasuhito, Rai, Shinya, Izutsu, Koji, Yamaguchi, Motoko, Takizawa, Jun, Kuroda, Junya, Ishikawa, Takayuki, Kato, Koji, Suehiro, Youko, Fukuhara, Noriko, Ohmine, Ken, Goto, Hideki, Yamamoto, Kazuhito, Kanemura, Nobuhiro, Ueda, Yasunori, Ishizawa, Kenichi, Kumagai, Kyoya, Kawasaki, Atsuko, Saito, Tomohisa, Hashizume, Misato, Shibayama, Hirohiko
Published in Cancer science (01.07.2021)
Published in Cancer science (01.07.2021)
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Journal Article
Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study)
Izumi, Keisuke, Kaneko, Yuko, Hashizume, Misato, Yoshimoto, Keiko, Takeuchi, Tsutomu
Published in PloS one (23.12.2015)
Published in PloS one (23.12.2015)
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Journal Article
Anti‐interleukin‐6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen‐induced arthritis model
Tanaka, Keisuke, Hashizume, Misato, Mihara, Masahiko, Yoshida, Hiroto, Suzuki, Miho, Matsumoto, Yoshihiro
Published in Clinical and experimental immunology (01.02.2014)
Published in Clinical and experimental immunology (01.02.2014)
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Journal Article
Tocilizumab, A Humanized Anti-IL-6R Antibody, as an Emerging Therapeutic Option for Rheumatoid Arthritis: Molecular and Cellular Mechanistic Insights
Hashizume, Misato, Tan, Seng-Lai, Takano, Junichi, Ohsawa, Kazunori, Hasada, Ikuo, Hanasaki, Akira, Ito, Ichiro, Mihara, Masahiko, Nishida, Keiichiro
Published in International Reviews of Immunology (04.05.2015)
Published in International Reviews of Immunology (04.05.2015)
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Journal Article
Correction: Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study)
Izumi, Keisuke, Kaneko, Yuko, Hashizume, Misato, Yoshimoto, Keiko, Takeuchi, Tsutomu
Published in PloS one (2016)
Published in PloS one (2016)
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Journal Article
Tocilizumab, a Humanized Anti-interleukin-6 Receptor Antibody, Ameliorates Joint Swelling in Established Monkey Collagen-Induced Arthritis
Uchiyama, Yasushi, Yorozu, Keigo, Hashizume, Misato, Moriya, Yoichiro, Mihara, Masahiko
Published in Biological & Pharmaceutical Bulletin (01.06.2008)
Published in Biological & Pharmaceutical Bulletin (01.06.2008)
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Journal Article
Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate
O'Mahony, Alison, John, Markus R, Cho, Hannah, Hashizume, Misato, Choy, Ernest H
Published in Journal of translational medicine (07.06.2018)
Published in Journal of translational medicine (07.06.2018)
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Journal Article
High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis
Hashizume, Misato, Koike, Nobuo, Yoshida, Hiroto, Suzuki, Miho, Mihara, Masahiko
Published in Modern rheumatology (01.10.2010)
Published in Modern rheumatology (01.10.2010)
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Journal Article
Induction of high-dose tolerance to the rat anti-mouse IL-6 receptor antibody in NZB/NZW F1 mice
Yoshida, Hiroto, Hashizume, Misato, Suzuki, Miho, Mihara, Masahiko
Published in Rheumatology international (01.11.2011)
Published in Rheumatology international (01.11.2011)
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Journal Article
Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model
Hashizume, Misato, Yoshida, Hiroto, Tanaka, Keisuke, Suzuki, Miho, Matsumoto, Isao, Sumida, Takayuki, Mihara, Masahiko
Published in Arthritis research & therapy (30.04.2012)
Published in Arthritis research & therapy (30.04.2012)
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Journal Article
Striking Species Difference in the Contribution of Concentrative Nucleoside Transporter 2 to Nucleoside Uptake between Mouse and Rat Hepatocytes
FURIHATA, Tomomi, FUKUCHI, Yukina, IIKURA, Minami, HASHIZUME, Misato, MIYAJIMA, Atsushi, NAGAI, Miki, CHIBA, Kan
Published in Antimicrobial Agents and Chemotherapy (01.07.2010)
Published in Antimicrobial Agents and Chemotherapy (01.07.2010)
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Journal Article
High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis
Hashizume, Misato, Koike, Nobuo, Yoshida, Hiroto, Suzuki, Miho, Mihara, Masahiko
Published in Modern rheumatology (01.10.2010)
Published in Modern rheumatology (01.10.2010)
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Journal Article