Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration
Ishida, Kazuhisa, Yamada, Kaoru, Nishiyama, Risa, Hashimoto, Tadafumi, Nishida, Itaru, Abe, Yoichiro, Yasui, Masato, Iwatsubo, Takeshi
Published in The Journal of experimental medicine (07.03.2022)
Published in The Journal of experimental medicine (07.03.2022)
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Journal Article
Characterization of the unique In Vitro effects of unsaturated fatty acids on the formation of amyloid β fibrils
Eto, Miki, Hashimoto, Tadafumi, Shimizu, Takao, Iwatsubo, Takeshi
Published in PloS one (10.07.2019)
Published in PloS one (10.07.2019)
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Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer's disease
Wakabayashi, Tomoko, Yamaguchi, Kazuki, Matsui, Kentaro, Sano, Toshiharu, Kubota, Tetsuya, Hashimoto, Tadafumi, Mano, Ayako, Yamada, Kaoru, Matsuo, Yuko, Kubota, Naoto, Kadowaki, Takashi, Iwatsubo, Takeshi
Published in Molecular neurodegeneration (12.04.2019)
Published in Molecular neurodegeneration (12.04.2019)
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Journal Article
Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
Koffie, Robert M, Meyer-Luehmann, Melanie, Hashimoto, Tadafumi, Adams, Kenneth W, Mielke, Matthew L, Garcia-Alloza, Monica, Micheva, Kristina D, Smith, Stephen J, Kim, M. Leo, Lee, Virginia M, Hyman, Bradley T, Spires-Jones, Tara L
Published in Proceedings of the National Academy of Sciences - PNAS (10.03.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (10.03.2009)
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Journal Article
Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease
Yamamoto, Kaoru, Tanei, Zen-ichi, Hashimoto, Tadafumi, Wakabayashi, Tomoko, Okuno, Hiroyuki, Naka, Yasushi, Yizhar, Ofer, Fenno, Lief E., Fukayama, Masashi, Bito, Haruhiko, Cirrito, John R., Holtzman, David M., Deisseroth, Karl, Iwatsubo, Takeshi
Published in Cell reports (Cambridge) (12.05.2015)
Published in Cell reports (Cambridge) (12.05.2015)
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Journal Article
ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity
An, Haiyan, Litscher, Gioana, Watanabe, Naruaki, Wei, Wenbin, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Buchman, Vladimir L., Shelkovnikova, Tatyana A.
Published in Neurobiology of disease (01.01.2022)
Published in Neurobiology of disease (01.01.2022)
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Journal Article
Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease
Mano, Tatsuo, Nagata, Kenichi, Nonaka, Takashi, Tarutani, Airi, Imamura, Tomohiro, Hashimoto, Tadafumi, Bannai, Taro, Koshi-Mano, Kagari, Tsuchida, Takeyuki, Ohtomo, Ryo, Takahashi-Fujigasaki, Junko, Yamashita, Satoshi, Ohyagi, Yasumasa, Yamasaki, Ryo, Tsuji, Shoji, Tamaoka, Akira, Ikeuchi, Takeshi, Saido, Takaomi C., Iwatsubo, Takeshi, Ushijima, Toshikazu, Murayama, Shigeo, Hasegawa, Masato, Iwata, Atsushi
Published in Proceedings of the National Academy of Sciences - PNAS (07.11.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (07.11.2017)
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Journal Article
Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy
Matsukawa, Koji, Kukharsky, Michail S., Park, Sei-Kyoung, Park, Sangeun, Watanabe, Naruaki, Iwatsubo, Takeshi, Hashimoto, Tadafumi, Liebman, Susan W., Shelkovnikova, Tatyana A.
Published in RNA biology (02.11.2021)
Published in RNA biology (02.11.2021)
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Journal Article
Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration
Matsumoto, Taisei, Matsukawa, Koji, Watanabe, Naruaki, Kishino, Yuya, Kunugi, Hayato, Ihara, Ryoko, Wakabayashi, Tomoko, Hashimoto, Tadafumi, Iwatsubo, Takeshi
Published in Human molecular genetics (15.04.2018)
Published in Human molecular genetics (15.04.2018)
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Journal Article
Novel high-strength, micro fibrillated cellulose-reinforced polypropylene composites using a cationic polymer as compatibilizer
Suzuki, Katsuhito, Sato, Akihiro, Okumura, Hiroaki, Hashimoto, Tadafumi, Nakagaito, Antonio Norio, Yano, Hiroyuki
Published in Cellulose (London) (01.02.2014)
Published in Cellulose (London) (01.02.2014)
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Journal Article
Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight
Bannai, Taro, Mano, Tatsuo, Chen, Xigui, Ohtomo, Gaku, Ohtomo, Ryo, Tsuchida, Takeyuki, Koshi-Mano, Kagari, Hashimoto, Tadafumi, Okazawa, Hitoshi, Iwatsubo, Takeshi, Tsuji, Shoji, Toda, Tatsushi, Iwata, Atsushi
Published in Scientific reports (26.02.2019)
Published in Scientific reports (26.02.2019)
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Journal Article
Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder
Munezane, Haruka, Oizumi, Hiroaki, Wakabayashi, Tomoko, Nishio, Shu, Hirasawa, Tomoko, Sato, Takashi, Harada, Akihiro, Yoshida, Tomoyuki, Eguchi, Takahiro, Yamanashi, Yuji, Hashimoto, Tadafumi, Iwatsubo, Takeshi
Published in Cell reports (Cambridge) (24.12.2019)
Published in Cell reports (Cambridge) (24.12.2019)
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Journal Article
Numerical Prediction of Axial Residual Stress Relaxation caused by Bending-Straightening in Quenching-Induction-Hardened Axle Shafts
Okano, Shigetaka, Makimoto, Teppei, Hashimoto, Tadafumi, Kawahara, Masaaki, Mochizuki, Masahito
Published in International Journal of Automotive Engineering (2023)
Published in International Journal of Automotive Engineering (2023)
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Journal Article
Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease
Hudry, Eloise, Wu, Hai-Yan, Arbel-Ornath, Michal, Hashimoto, Tadafumi, Matsouaka, Roland, Fan, Zhanyun, Spires-Jones, Tara L, Betensky, Rebecca A, Bacskai, Brian J, Hyman, Bradley T
Published in The Journal of neuroscience (29.02.2012)
Published in The Journal of neuroscience (29.02.2012)
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Journal Article
RNA aptamer probes as optical imaging agents for the detection of amyloid plaques
Farrar, Christian T, William, Christopher M, Hudry, Eloise, Hashimoto, Tadafumi, Hyman, Bradley T
Published in PloS one (26.02.2014)
Published in PloS one (26.02.2014)
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Journal Article
Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43
Matsukawa, Koji, Hashimoto, Tadafumi, Matsumoto, Taisei, Ihara, Ryoko, Chihara, Takahiro, Miura, Masayuki, Wakabayashi, Tomoko, Iwatsubo, Takeshi
Published in The Journal of biological chemistry (04.11.2016)
Published in The Journal of biological chemistry (04.11.2016)
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Journal Article
CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development
Tanaka, Tomohiro, Wakabayashi, Tomoko, Oizumi, Hiroaki, Nishio, Shu, Sato, Takashi, Harada, Akihiro, Fujii, Daisuke, Matsuo, Yuko, Hashimoto, Tadafumi, Iwatsubo, Takeshi
Published in The Journal of neuroscience (22.01.2014)
Published in The Journal of neuroscience (22.01.2014)
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Journal Article
Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies
Park, Sangeun, Park, Sei-Kyoung, Watanabe, Naruaki, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Shelkovnikova, Tatyana A, Liebman, Susan W
Published in PLoS genetics (01.08.2019)
Published in PLoS genetics (01.08.2019)
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Journal Article
Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques
Hashimoto, Tadafumi, Fujii, Daisuke, Naka, Yasushi, Kashiwagi-Hakozaki, Mayu, Matsuo, Yuko, Matsuura, Yusuke, Wakabayashi, Tomoko, Iwatsubo, Takeshi
Published in Acta neuropathologica communications (07.12.2020)
Published in Acta neuropathologica communications (07.12.2020)
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Journal Article
Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model
Abe, Yoichiro, Ikegawa, Natsumi, Yoshida, Keitaro, Muramatsu, Kyosuke, Hattori, Satoko, Kawai, Kenji, Murakami, Minetaka, Tanaka, Takumi, Goda, Wakami, Goto, Motohito, Yamamoto, Taichi, Hashimoto, Tadafumi, Yamada, Kaoru, Shibata, Terumasa, Misawa, Hidemi, Mimura, Masaru, Tanaka, Kenji F, Miyakawa, Tsuyoshi, Iwatsubo, Takeshi, Hata, Jun-Ichi, Niikura, Takako, Yasui, Masato
Published in Acta neuropathologica communications (12.05.2020)
Published in Acta neuropathologica communications (12.05.2020)
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