Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders
Noji, Satoru, Hara, Yoshinori, Miura, Tomoya, Yamanaka, Hiroshi, Maeda, Katsuya, Hori, Akimi, Yamamoto, Hiroshi, Obika, Shingo, Inoue, Masafumi, Hase, Yasunori, Orita, Takuya, Doi, Satoki, Adachi, Tsuyoshi, Tanimoto, Atsuo, Oki, Chika, Kimoto, Yukari, Ogawa, Yoshihiro, Negoro, Tamotsu, Hashimoto, Hiromasa, Shiozaki, Makoto
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952
Ikegashira, Kazutaka, Ikenogami, Taku, Yamasaki, Takayuki, Oka, Takahiro, Hase, Yasunori, Miyagawa, Naoki, Inagaki, Koji, Kawahara, Iichiro, Koga, Yoshihisa, Hashimoto, Hiromasa
Published in Bioorganic & medicinal chemistry letters (01.04.2019)
Published in Bioorganic & medicinal chemistry letters (01.04.2019)
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Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia
Ogoshi, Yosuke, Matsui, Takuya, Mitani, Ikuo, Yokota, Masahiro, Terashita, Masakazu, Motoda, Dai, Ueyama, Kazuhito, Hotta, Takahiro, Ito, Takashi, Hase, Yasunori, Fukui, Kenji, Deai, Katsuya, Yoshiuchi, Hiromi, Ito, Soichiro, Abe, Hiroyuki
Published in ACS medicinal chemistry letters (14.12.2017)
Published in ACS medicinal chemistry letters (14.12.2017)
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Discovery of Conformationally Constrained Tetracyclic Compounds as Potent Hepatitis C Virus NS5B RNA Polymerase Inhibitors
Ikegashira, Kazutaka, Oka, Takahiro, Hirashima, Shintaro, Noji, Satoru, Yamanaka, Hiroshi, Hara, Yoshinori, Adachi, Tsuyoshi, Tsuruha, Jun-Ichiro, Doi, Satoki, Hase, Yasunori, Noguchi, Toru, Ando, Izuru, Ogura, Naoki, Ikeda, Satoru, Hashimoto, Hiromasa
Published in Journal of medicinal chemistry (30.11.2006)
Published in Journal of medicinal chemistry (30.11.2006)
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Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors
Shiozaki, Makoto, Maeda, Katsuya, Miura, Tomoya, Kotoku, Masayuki, Yamasaki, Takayuki, Matsuda, Isamu, Aoki, Kenta, Yasue, Katsutaka, Imai, Hiroto, Ubukata, Minoru, Suma, Akira, Yokota, Masahiro, Hotta, Takahiro, Tanaka, Masahiro, Hase, Yasunori, Haas, Julia, Fryer, Andrew M, Laird, Ellen R, Littmann, Nicole M, Andrews, Steven W, Josey, John A, Mimura, Takayuki, Shinozaki, Yuichi, Yoshiuchi, Hiromi, Inaba, Takashi
Published in Journal of medicinal chemistry (28.04.2011)
Published in Journal of medicinal chemistry (28.04.2011)
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Comparison of stabilities of nitrenium ions and in vitro and in vivo genotoxic potential, between four aniline derivatives
Suzuki, Hidekazu, Ninoseki, Takuya, Hayashi, Ayumi, Hase, Yasunori, Matsui, Takuya, Naito, Masaru, Sugai, Shoichiro
Published in Fundamental Toxicological Sciences (2018)
Published in Fundamental Toxicological Sciences (2018)
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Synthesis and Structure−Activity Relationships of 5,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepine Derivatives: Novel Arginine Vasopressin Antagonists
Cho, Hidetsura, Murakami, Kengo, Nakanishi, Hiroyuki, Fujisawa, Akitaka, Isoshima, Hirotaka, Niwa, Misako, Hayakawa, Kazuhide, Hase, Yasunori, Uchida, Itsuo, Watanabe, Hidenori, Wakitani, Korekiyo, Aisaka, Kazuo
Published in Journal of medicinal chemistry (01.01.2004)
Published in Journal of medicinal chemistry (01.01.2004)
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Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models
Ikegashira, Kazutaka, Ikenogami, Taku, Yamasaki, Takayuki, Hase, Yasunori, Yamaguchi, Takayuki, Inagaki, Koji, Doi, Satoki, Adachi, Tsuyoshi, Koga, Yoshihisa, Hashimoto, Hiromasa
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
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Journal Article
Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold
Kotoku, Masayuki, Maeba, Takaki, Fujioka, Shingo, Yokota, Masahiro, Seki, Noriyoshi, Ito, Keisuke, Suwa, Yoshihiro, Ikenogami, Taku, Hirata, Kazuyuki, Hase, Yasunori, Katsuda, Yoshiaki, Miyagawa, Naoki, Arita, Kojo, Asahina, Kota, Noguchi, Masato, Nomura, Akihiro, Doi, Satoki, Adachi, Tsuyoshi, Crowe, Paul, Tao, Haiyan, Thacher, Scott, Hashimoto, Hiromasa, Suzuki, Takayoshi, Shiozaki, Makoto
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF
SHIOZAKI MAKOTO, MIURA TOMOYA, YAMANAKA HIROSHI, MAEDA KATSUYA, INOUE AKIFUMI, HARA YOSHINORI, NOMICHI SATORU, HORI AKIMI, HASE YASUNORI
Year of Publication 02.10.2023
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Year of Publication 02.10.2023
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GROUND METAL FITTING
SAKAI KYOHEI, TAKAMATSU HAJIME, YAMASHITA KAZUYOSHI, SUGIHARA HIROAKI, WADA KENJI, MUKAI KAZUHIKO, SATO MASARU, HASE YASUNORI, KODAMA TAKESHI
Year of Publication 18.05.2023
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Year of Publication 18.05.2023
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SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR gamma Inhibitor
Hirata, Kazuyuki, Kotoku, Masayuki, Seki, Noriyoshi, Maeba, Takaki, Maeda, Katsuya, Hirashima, Shintaro, Sakai, Takayuki, Obika, Shingo, Hori, Akimi, Hase, Yasunori, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Hata, Takahiro, Miyagawa, Naoki, Arita, Kojo, Nomura, Yukihiro, Asahina, Kota, Aratsu, Yusuke, Kamada, Masafumi, Adachi, Tsuyoshi, Noguchi, Masato, Doi, Satoki, Crowe, Paul, Bradley, Erin, Steensma, Ruo, Tao, Haiyan, Fenn, Morgan, Babine, Robert, Li, Xiaolin, Thacher, Scott, Hashimoto, Hiromasa, Shiozaki, Makoto
Published in ACS medicinal chemistry letters (14.01.2016)
Published in ACS medicinal chemistry letters (14.01.2016)
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SNOW ACCRETION PREVENTING DEVICE FOR OVERHEAD WIRE
SAKAI KYOHEI, TAKAMATSU HAJIME, YAMASHITA KAZUYOSHI, SUGIHARA MASASHI, SUGIHARA HIROAKI, MUKAI KAZUHIKO, SATO MASARU, HASE YASUNORI, HARADA HAYATO, KODAMA TAKESHI
Year of Publication 25.07.2022
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Year of Publication 25.07.2022
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NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF
SHIOZAKI MAKOTO, MIURA TOMOYA, YAMANAKA HIROSHI, MAEDA KATSUYA, INOUE AKIFUMI, HARA YOSHINORI, NOMICHI SATORU, HORI AKIMI, HASE YASUNORI
Year of Publication 02.12.2021
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Year of Publication 02.12.2021
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NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF
SHIOZAKI MAKOTO, MIURA TOMOYA, YAMANAKA HIROSHI, MAEDA KATSUYA, INOUE AKIFUMI, HARA YOSHINORI, NOMICHI SATORU, HORI AKIMI, HASE YASUNORI
Year of Publication 05.03.2020
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Year of Publication 05.03.2020
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CUTTING WIRE ATTACHMENT DEVICE
KUWATA MASAYUKI, TAKAYAMA HIROAKI, NISHIYAMA FUMINORI, YAMAMOTO KOICHIRO, KISHIMOTO TAKEYA, MORIMOTO DAIKI, NAITO NAOTAKA, YAMAMOTO JUNICHIRO, MUKAI KAZUHIKO, HASE YASUNORI
Year of Publication 12.12.2019
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Year of Publication 12.12.2019
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FUJIWARA ISAMU, KUWATA MASAYUKI, TAKAYAMA HIROAKI, NISHIYAMA FUMINORI, YAMAMOTO KOICHIRO, GOSHA MICHIO, MORIMOTO DAIKI, YAMAMOTO JUNICHIRO, MUKAI KAZUHIKO, HASE YASUNORI
Year of Publication 20.12.2018
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Year of Publication 20.12.2018
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NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF
SHIOZAKI MAKOTO, MIURA TOMOYA, YAMANAKA HIROSHI, MAEDA KATSUYA, INOUE AKIFUMI, HARA YOSHINORI, NOMICHI SATORU, HORI AKIMI, HASE YASUNORI
Year of Publication 19.07.2018
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Year of Publication 19.07.2018
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