SHIP1 SHIP1 MODULATORS AND METHODS RELATED THERETO
RAYMOND JEFFERY R, BOGUCKI DAVID, MACKENZIE LLOYD F, MACRURY THOMAS B, HARWIG CURTIS, PETTIGREW JEREMY D
Year of Publication 05.08.2022
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Year of Publication 05.08.2022
Patent
Abstract 1871: Development of pelorol analogues to activate the SHIP1 lipid phosphatase; a novel paradigm to suppress B-cell receptor signaling in human B-cell cancers
Packham, Graham, Lemm, Elizabeth, Valle-Argos, Beatriz, Smith, Lindsay, Weston-Bell, Nichola, Stevenson, Freda, Carter, Matthew J., Cragg, Mark S., Forconi, Francesco, Steele, Andrew J., Cross, Jennifer, Harwig, Curtis, Lenz, Georg, Mackenzie, Lloyd, Klener, Pavel
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
SHIP1 SHIP1 MODULATORS AND METHODS RELATED THERETO
RAYMOND JEFFERY R, BOGUCKI DAVID, MACKENZIE LLOYD F, MACRURY THOMAS B, HARWIG CURTIS, PETTIGREW JEREMY D
Year of Publication 06.10.2021
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Year of Publication 06.10.2021
Patent
Chemical Activation of the SHIP1 Inositol Lipid Phosphatase: A Novel Therapeutic Strategy to Suppress B-Cell Receptor Signaling and CXCR4 Expression in Malignant Human B Cells
Packham, Graham, Valle-Argos, Beatriz, Lemm, Elizabeth, Smith, Lindsay D, Weston-Bell, Nicola J, Gebreselassie, Yohannes, Steele, Andrew J, Stevenson, Freda K, Cragg, Mark S, Forconi, Francesco, Cross, Jennifer, Harwig, Curtis, Mackenzie, Lloyd
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
Taxamycins: a new enediyne family with synthetic and biological potential
Lu, Yee-Fung, Harwig, Curtis W, Fallis, Alex G
Published in Canadian journal of chemistry (01.12.1995)
Published in Canadian journal of chemistry (01.12.1995)
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Journal Article
Synthesis and characterization of 2,6-difluoro-4-carboxyphenylboronic acid and a biotin derivative thereof as captors of anionic aqueous [ 18F]-fluoride for the preparation of [ 18F/ 19F]-labeled aryltrifluoroborates with high kinetic stability
Harwig, Curtis W., Ting, Richard, Adam, Michael J., Ruth, Thomas J., Perrin, David M.
Published in Tetrahedron letters (05.05.2008)
Published in Tetrahedron letters (05.05.2008)
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Journal Article
Synthesis of SHIP1-Activating Analogs of the Sponge Meroterpenoid Pelorol
Meimetis, Labros G., Nodwell, Matt, Yang, Lu, Wang, Xiaoxia, Wu, Joyce, Harwig, Curtis, Stenton, Grant R., Mackenzie, Lloyd F., MacRury, Thomas, Patrick, Brian O., Ming-Lum, Andrew, Ong, Christopher J., Krystal, Gerald, Mui, Alice L. -F., Andersen, Raymond J.
Published in European journal of organic chemistry (01.09.2012)
Published in European journal of organic chemistry (01.09.2012)
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Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication
Skerlj, Renato, Bridger, Gary, McEachern, Ernie, Harwig, Curtis, Smith, Chris, Wilson, Trevor, Veale, Duane, Yee, Helen, Crawford, Jason, Skupinska, Krystyna, Wauthy, Rossana, Yang, Wen, Zhu, Yongbao, Bogucki, David, Di Fluri, Maria, Langille, Jonathon, Huskens, Dana, De Clercq, Erik, Schols, Dominique
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis
Stenton, Grant R, Mackenzie, Patrick Tam, Lloyd F, Cross, Jennifer L, Harwig, Curtis, Raymond, Jeffrey, Toews, Judy, Wu, Joyce, Ogden, Nancy, MacRury, Thomas, Szabo, Csaba
Published in British journal of pharmacology (25.02.2013)
Published in British journal of pharmacology (25.02.2013)
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Journal Article
Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models
Stenton, Grant R, Mackenzie, Patrick Tam, Lloyd F, Cross, Jennifer L, Harwig, Curtis, Raymond, Jeffrey, Toews, Judy, Chernoff, David, MacRury, Thomas, Szabo, Csaba
Published in British journal of pharmacology (25.02.2013)
Published in British journal of pharmacology (25.02.2013)
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Journal Article
Design of Substituted lmidazolidinylpiperidinylbenzoic Acids as Chemokine Receptor 5 Antagonists: Potent Inhibitors of R5 HIV-1 Replication
Skerlj, Renato, Bridge, Gary, Zhou, Yuanxi, Bourque, Elyse, McEachern, Ernest, Metz, Markus, Harwig, Curtis, Li, Tong-Shuang, Yang, Wen, Bogucki, David, Zhu, Yongbao, Langille, Jonathan, Veale, Duane, Ba, Tuya, Bey, Michael, Baird, Ian, Kaller, Alan, Krumpak, Maria, Leitch, David, Satori, Michael, Vocadlo, Krystyna, Guay, Danielle, Nan, Susan, Yee, Helen, Crawford, Jason, Chen, Gang, Wilson, Trevor, Carpenter, Bryon, Gauthier, David, MacFarland, Ron, Mosi, Renee, Bodart, Veronique, Wong, Rebecca, Fricker, Simon, Schols, Dominique
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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Journal Article
Design of Substituted Imidazolidinylpiperidinylbenzoic Acids as Chemokine Receptor 5 Antagonists: Potent Inhibitors of R5 HIV‑1 Replication
Skerlj, Renato, Bridger, Gary, Zhou, Yuanxi, Bourque, Elyse, McEachern, Ernest, Metz, Markus, Harwig, Curtis, Li, Tong-Shuang, Yang, Wen, Bogucki, David, Zhu, Yongbao, Langille, Jonathan, Veale, Duane, Ba, Tuya, Bey, Michael, Baird, Ian, Kaller, Alan, Krumpak, Maria, Leitch, David, Satori, Michael, Vocadlo, Krystyna, Guay, Danielle, Nan, Susan, Yee, Helen, Crawford, Jason, Chen, Gang, Wilson, Trevor, Carpenter, Bryon, Gauthier, David, MacFarland, Ron, Mosi, Renee, Bodart, Veronique, Wong, Rebecca, Fricker, Simon, Schols, Dominique
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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Journal Article
Prospective CCR5 Small Molecule Antagonist Compound Design Using a Combined Mutagenesis/Modeling Approach
Metz, Markus, Bourque, Elyse, Labrecque, Jean, Danthi, Sanjay J, Langille, Jonathan, Harwig, Curtis, Yang, Wen, Darkes, Marilyn C, Lau, Gloria, Santucci, Zefferino, Bridger, Gary J, Schols, Dominique, Fricker, Simon P, Skerlj, Renato T
Published in Journal of the American Chemical Society (19.10.2011)
Published in Journal of the American Chemical Society (19.10.2011)
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Journal Article
Taxamycin Studies: CrCl(2)/NiCl(2)-Mediated Cyclizations and Unusual SeO(2) Oxidations
Harwig, Curtis W., Py, Sandrine, Fallis, Alex G.
Published in Journal of organic chemistry (14.11.1997)
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Published in Journal of organic chemistry (14.11.1997)
Journal Article
Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication
Skerlj, Renato, Bridger, Gary, McEachern, Ernest, Harwig, Curtis, Smith, Chris, Kaller, Alan, Veale, Duane, Yee, Helen, Skupinska, Krystyna, Wauthy, Rossana, Wang, Letian, Baird, Ian, Zhu, Yongbao, Burrage, Kate, Yang, Wen, Sartori, Michael, Huskens, Dana, Clercq, Erik De, Schols, Dominique
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Journal Article
Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication
Skerlj, Renato, Bridger, Gary, Zhou, Yuanxi, Bourque, Elyse, McEachern, Ernest, Langille, Jonathan, Harwig, Curtis, Veale, Duane, Yang, Wen, Li, Tongshong, Zhu, Yongbao, Bey, Michael, Baird, Ian, Sartori, Michael, Metz, Markus, Mosi, Renee, Nelson, Kim, Bodart, Veronique, Wong, Rebecca, Fricker, Simon, Mac Farland, Ron, Huskens, Dana, Schols, Dominique
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
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Journal Article
SHIP1 MODULATORS AND METHODS RELATED THERETO
RAYMOND JEFFERY R, BOGUCKI DAVID, MACKENZIE LLOYD F, HARWIG CURTIS, PETTIGREW JEREMY D
Year of Publication 23.11.2015
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Year of Publication 23.11.2015
Patent
SHIP1 MODULATORS AND METHODS RELATED THERETO
RAYMOND JEFFERY R, BOGUCKI DAVID, MACKENZIE LLOYD F, MACRURY THOMAS B, HARWIG CURTIS, PETTIGREW JEREMY D
Year of Publication 16.11.2015
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Year of Publication 16.11.2015
Patent
AMD070, a CXCR4 Chemokine Receptor Antagonist: Practical Large-Scale Laboratory Synthesis
Crawford, Jason B, Chen, Gang, Gauthier, David, Wilson, Trevor, Carpenter, Bryon, Baird, Ian R, McEachern, Ernie, Kaller, Alan, Harwig, Curtis, Atsma, Bem, Skerlj, Renato T, Bridger, Gary J
Published in Organic process research & development (19.09.2008)
Published in Organic process research & development (19.09.2008)
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Journal Article
SHIP1 MODULATORS AND METHODS RELATED THERETO
RAYMOND JEFFERY R, BOGUCKI DAVID, MACKENZIE LLOYD F, MACRURY THOMAS B, HARWIG CURTIS, KHLEBNIKOV VLADIMIR, SHAN RUDONG, PETTIGREW JEREMY D
Year of Publication 22.09.2015
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Year of Publication 22.09.2015
Patent