Synthesis and Biological Evaluation of 8-Oxoadenine Derivatives as Toll-like Receptor 7 Agonists Introducing the Antedrug Concept
Kurimoto, Ayumu, Hashimoto, Kazuki, Nakamura, Tomoaki, Norimura, Kei, Ogita, Haruhisa, Takaku, Haruo, Bonnert, Roger, McInally, Tom, Wada, Hiroki, Isobe, Yoshiaki
Published in Journal of medicinal chemistry (08.04.2010)
Published in Journal of medicinal chemistry (08.04.2010)
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Intratracheal and oral administration of SM‐276001: A selective TLR7 agonist, leads to antitumor efficacy in primary and metastatic models of cancer
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Published in International journal of cancer (01.02.2013)
Published in International journal of cancer (01.02.2013)
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Mechanism of action of inhibition of allergic immune responses by a novel antedrug TLR7 agonist
Matsui, Hiroyuki, Tomizawa, Hideyuki, Eiho, Kazuo, Kashiwazaki, Yasuo, Edwards, Susan, Biffen, Mark, Bell, John P, Bahl, Ashwani, Leishman, Andrew J, Murray, Clare M, Takaku, Haruo, Ueda, Yutaka
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Structure–activity relationships of novel HIV-1 protease inhibitors containing the 3-amino-2-chlorobenzoyl-allophenylnorstatine structure
Mimoto, Tsutomu, Nojima, Satoshi, Terashima, Keisuke, Takaku, Haruo, Shintani, Makoto, Hayashi, Hideya
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Structure−Activity Relationship of Small-Sized HIV Protease Inhibitors Containing Allophenylnorstatine
Mimoto, Tsutomu, Kato, Ryohei, Takaku, Haruo, Nojima, Satoshi, Terashima, Keisuke, Misawa, Satoru, Fukazawa, Tominaga, Ueno, Takamasa, Sato, Hideharu, Shintani, Makoto, Kiso, Yoshiaki, Hayashi, Hideya
Published in Journal of medicinal chemistry (20.05.1999)
Published in Journal of medicinal chemistry (20.05.1999)
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Structure–activity and structure–metabolism relationships of HIV protease inhibitors containing the 3-hydroxy-2-methylbenzoyl-allophenylnorstatine structure
Mimoto, Tsutomu, Terashima, Keisuke, Nojima, Satoshi, Takaku, Haruo, Nakayama, Mitsunobu, Shintani, Makoto, Yamaoka, Takashi, Hayashi, Hideya
Published in Bioorganic & medicinal chemistry (02.01.2004)
Published in Bioorganic & medicinal chemistry (02.01.2004)
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Anti‐tumor Activity of Arginine Deiminase from Mycoplasma arginini and Its Growth‐inhibitory Mechanism
Takaku, Haruo, Matsumoto, Mitsuhiro, Misawa, Satoru, Miyazaki, Kaoru
Published in Cancer science (01.09.1995)
Published in Cancer science (01.09.1995)
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Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere
MIMOTO, Tsutomu, HATTORI, Naoko, TAKAKU, Haruo, KISANUKI, Sumitsugu, FUKAZAWA, Tominaga, TERASHIMA, Keisuke, KATO, Ryohei, NOJIMA, Satoshi, MISAWA, Satoru, UENO, Takamasa, IMAI, Junya, ENOMOTO, Hiroshi, TANAKA, Shigeki, SAKIKAWA, Hiroshi, SHINTANI, Makoto, HAYASHI, Hideya, KISO, Yoshiaki
Published in Chemical & pharmaceutical bulletin (01.09.2000)
Published in Chemical & pharmaceutical bulletin (01.09.2000)
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Prodrugs of 9-Benzyl-8-hydroxy-2-(2-hydroxyethylthio)adenine: Potent Interferon Inducing Agents in Monkeys
Kurimoto, Ayumu, Tobe, Masanori, Ogita, Haruhisa, Ogino, Tetsuhiro, Takaku, Haruo, Ichii, Shinji, Kawakami, Hajime, Isobe, Yoshiaki
Published in Chemical & pharmaceutical bulletin (01.04.2004)
Published in Chemical & pharmaceutical bulletin (01.04.2004)
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Synthesis of Potent and Selective Inhibitors against the Proliferation of Human Coronary Artery Smooth Muscle Cells
Ogita, Haruhisa, Isobe, Yoshiaki, Takaku, Haruo, Sekine, Rena, Goto, Yuso, Misawa, Satoru, Hayashi, Hideya
Published in Chemical & Pharmaceutical Bulletin (01.02.2003)
Published in Chemical & Pharmaceutical Bulletin (01.02.2003)
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In vivo anti-tumor activity of arginine deiminase purified from Mycoplasma arginini
Takaku, H, Takase, M, Abe, S, Hayashi, H, Miyazaki, K
Published in International journal of cancer (08.05.1992)
Published in International journal of cancer (08.05.1992)
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Prodrugs of 9-Benzyl-8-hydroxy-2-(2-hydroxyethylthio)adenine：Potent Interferon Inducing Agents in Monkeys
Ayumu KURIMOTO, Masanori TOBE, Haruhisa OGITA, Tetsuhiro OGINO, Haruo TAKAKU, Shinji ICHII, Hajime KAWAKAMI, Yoshiaki ISOBE
Published in Chemical & Pharmaceutical Bulletin (2004)
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Published in Chemical & Pharmaceutical Bulletin (2004)
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Synthesis and structure–activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells
Ogita, Haruhisa, Isobe, Yoshiaki, Takaku, Haruo, Sekine, Rena, Goto, Yuso, Misawa, Satoru, Hayashi, Hideya
Published in Bioorganic & medicinal chemistry letters (26.02.2001)
Published in Bioorganic & medicinal chemistry letters (26.02.2001)
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KNI-577, a Potent Small-Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition-State Mimic
Kiso, Yoshiaki, Yamaguchi, Satoshi, Matsumoto, Hikaru, Mimoto, Tsutomu, Kato, Ryohei, Nojima, Satoshi, Takaku, Haruo, Fukazawa, Tominaga, Kimura, Tooru, Akaji, Kenichi
Published in Archiv der Pharmazie (Weinheim) (01.03.1998)
Published in Archiv der Pharmazie (Weinheim) (01.03.1998)
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Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities
KURIMOTO, Ayumu, OGINO, Tetsuhiro, ICHII, Shinji, ISOBE, Yoshiaki, TOBE, Masanori, OGITA, Haruhisa, TAKAKU, Haruo, SAJIKI, Hironao, HIROTA, Kosaku, KAWAKAMI, Hajime
Published in Bioorganic & medicinal chemistry (01.03.2004)
Published in Bioorganic & medicinal chemistry (01.03.2004)
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Synthesis and Biological Evaluation of Novel 9-Substituted-8-Hydroxyadenine Derivatives as Potent Interferon Inducers
Isobe, Yoshiaki, Kurimoto, Ayumu, Tobe, Masanori, Hashimoto, Kazuki, Nakamura, Tomoaki, Norimura, Kei, Ogita, Haruhisa, Takaku, Haruo
Published in Journal of medicinal chemistry (23.03.2006)
Published in Journal of medicinal chemistry (23.03.2006)
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Discovery of 8-Hydroxyadenines as a Novel Type of Interferon Inducer
Hirota, Kosaku, Kazaoka, Kazunori, Niimoto, Itaru, Kumihara, Hiroshi, Sajiki, Hironao, Isobe, Yoshiaki, Takaku, Haruo, Tobe, Masanori, Ogita, Haruhisa, Ogino, Tetsuhiro, Ichii, Shinji, Kurimoto, Ayumu, Kawakami, Hajime
Published in Journal of medicinal chemistry (05.12.2002)
Published in Journal of medicinal chemistry (05.12.2002)
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Synthesis and structure–Activity relationships of 2-Amino-8-hydroxyadenines as orally active interferon inducing agents
Kurimoto, Ayumu, Ogino, Tetsuhiro, Ichii, Shinji, Isobe, Yoshiaki, Tobe, Masanori, Ogita, Haruhisa, Takaku, Haruo, Sajiki, Hironao, Hirota, Kosaku, Kawakami, Hajime
Published in Bioorganic & medicinal chemistry (01.12.2003)
Published in Bioorganic & medicinal chemistry (01.12.2003)
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