11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice
García, Ricardo A, Search, Debra J, Lupisella, John A, Ostrowski, Jacek, Guan, Bo, Chen, Jian, Yang, Wen-Pin, Truong, Amy, He, Aiqing, Zhang, Rongan, Yan, Mujing, Hellings, Samuel E, Gargalovic, Peter S, Ryan, Carol S, Watson, Linda M, Langish, Robert A, Shipkova, Petia A, Carson, Nancy L, Taylor, Joseph R, Yang, Richard, Psaltis, George C, Harrity, Thomas W, Robl, Jeffrey A, Gordon, David A
Published in PloS one (01.02.2013)
Published in PloS one (01.02.2013)
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Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)
Sulsky, Richard, Magnin, David R., Huang, Yanting, Simpkins, Ligaya, Taunk, Prakash, Patel, Manorama, Zhu, Yeheng, Stouch, Terry R., Bassolino-Klimas, Donna, Parker, Rex, Harrity, Thomas, Stoffel, Robert, Taylor, David S., Lavoie, Thomas B., Kish, Kevin, Jacobson, Bruce L., Sheriff, Steven, Adam, Leonard P., Ewing, William R., Robl, Jeffrey A.
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
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PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor
Hangeland, Jon J., Abell, Lynn M., Adam, Leonard P., Jiang, Ji, Friends, Todd J., Haque, Lauren E., Neels, James, Onorato, Joelle M., Chen, Alice Ye A., Taylor, David S., Yin, Xiaohong, Harrity, Thomas W., Basso, Michael D., Yang, Richard, Sleph, Paul G., Gordon, David A., Huang, Christine S., Wexler, Ruth R., Finlay, Heather J., Lawrence, R. Michael
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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The Ability of Statins to Inhibit Bone Resorption Is Directly Related to Their Inhibitory Effect on HMG‐CoA Reductase Activity
Staal, Ada, Frith, Julie C, French, Michele H, Swartz, Joann, Güngör, Timur, Harrity, Thomas W, Tamasi, Joseph, Rogers, Michael J, Feyen, Jean HM
Published in Journal of bone and mineral research (01.01.2003)
Published in Journal of bone and mineral research (01.01.2003)
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Muraglitazar, a Novel Dual (α/γ) Peroxisome Proliferator–Activated Receptor Activator, Improves Diabetes and Other Metabolic Abnormalities and Preserves β-Cell Function in db/db Mice
HARRITY, Thomas, FARRELLY, Dennis, WEI WANG, HAO ZHANG, FENDERSON, William, CHEN, Sean, DEVASTHALE, Pratik, JEON, Yoon, SEETHALA, Ramakrishna, YANG, Wen-Pin, REN, Jimmy, MIN ZHOU, TIEMAN, Aaron, RYONO, Denis, BILLER, Scott, MOOKHTIAR, Kasim A, WETTERAU, John, GREGG, Richard, CHENG, Peter T, HARIHARAN, Narayanan, CUIXIA CHU, KUNSELMAN, Lori, LIQUN GU, PONTICIELLO, Randolph, CAP, Michael, FUCHENG QU, CHUNNING SHAO
Published in Diabetes (New York, N.Y.) (01.01.2006)
Published in Diabetes (New York, N.Y.) (01.01.2006)
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The Guinea Pig as a Preclinical Model for Demonstrating the Efficacy and Safety of Statins
Madsen, Cort S, Janovitz, Evan, Zhang, Rongan, Nguyen-Tran, Van, Ryan, Carol S, Yin, Xiaohong, Monshizadegan, Hossain, Chang, Ming, D'Arienzo, Celia, Scheer, Susan, Setters, Robert, Search, Debra, Chen, Xing, Zhuang, Shaobin, Kunselman, Lori, Peters, Andrew, Harrity, Thomas, Apedo, Atsu, Huang, Christine, Cuff, Carolyn A, Kowala, Mark C, Blanar, Michael A, Sun, Chong-Qing, Robl, Jeffrey A, Stein, Philip D
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
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5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP
Sulsky, Richard, Robl, Jeffrey A., Biller, Scott A., Harrity, Thomas W., Wetterau, John, Connolly, Fergal, Jolibois, Kern, Kunselman, Lori
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
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Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents
Magnin, David R, Biller, Scott A, Wetterau, John, Robl, Jeffrey A, Dickson, John K, Taunk, Prakash, Harrity, Thomas W, Lawrence, R.Michael, Sun, C.-Q, Wang, Tammy, Logan, Janette, Fryszman, Olga, Connolly, Fergal, Jolibois, Kern, Kunselman, Lori
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
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A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors
Robl, Jeffrey A, Sulsky, Richard, Sun, Chong-Qing, Simpkins, Ligaya M, Wang, Tammy, Dickson, John K, Chen, Ying, Magnin, David R, Taunk, Prakash, Slusarchyk, William A, Biller, Scott A, Lan, Shih-Jung, Connolly, Fergal, Kunselman, Lori K, Sabrah, Talal, Jamil, Haris, Gordon, David, Harrity, Thomas W, Wetterau, John R
Published in Journal of medicinal chemistry (15.03.2001)
Published in Journal of medicinal chemistry (15.03.2001)
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Orally Active Squalene Synthase Inhibitors: Bis((acyloxy)alkyl) Prodrugs of the α-Phosphonosulfonic Acid Moiety
Dickson, John K, Biller, Scott A, Magnin, David R, Petrillo, Edward W, Hillyer, John W, Hsieh, Dolly C, Lan, Shih-Jung, Rinehart, J. Kent, Gregg, Richard E, Harrity, Thomas W, Jolibois, Kern G, Kalinowski, Stephen S, Kunselman, Lori K, Mookhtiar, Kasim A, Ciosek, Carl P
Published in Journal of medicinal chemistry (02.02.1996)
Published in Journal of medicinal chemistry (02.02.1996)
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Enantioselective Synthesis of α-Phosphono Sulfonate Squalene Synthase Inhibitors: Chiral Recognition in the Interactions of an α-Phosphono Sulfonate Inhibitor with Squalene Synthase
Lawrence, R. Michael, Biller, Scott A, Dickson, John K, Logan, Janette V. H, Magnin, David R, Sulsky, Richard B, DiMarco, John D, Gougoutas, Jack Z, Beyer, Barbara D, Taylor, Susan C, Lan, Shih-Jung, Ciosek, Carl P, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Slusarchyk, Dorothy A
Published in Journal of the American Chemical Society (20.11.1996)
Published in Journal of the American Chemical Society (20.11.1996)
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1,1-Bisphosphonate Squalene Synthase Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate
Magnin, David R, Dickson, John K, Logan, Janette V, Lawrence, R. Michael, Chen, Ying, Sulsky, Richard B, Ciosek, Carl P, Biller, Scott A, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Rich, Lois C, Slusarchyk, Dorothy A
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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The first potent inhibitor of squalene synthase: a profound contribution of an ether oxygen to inhibitor-enzyme interaction
Biller, Scott A, Sofia, Michael J, DeLange, Barbara, Forster, Cornelia, Gordon, Eric M, Harrity, Thomas, Rich, Lois C, Ciosek, Carl P
Published in Journal of the American Chemical Society (01.10.1991)
Published in Journal of the American Chemical Society (01.10.1991)
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Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3 '-hydroxyazetidin-1-yl)ethanone [BMS-8163361, an Orally Active Novel Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor
Ye, Xiang-Yang, Chen, Stephanie Y., Wu, Shung, Yoon, David S., Wang, Haixia, Hong, Zhenqiu, O'Connor, Stephen P., Li, Jun, Li, James J., Kennedy, Lawrence J., Walker, Steven J., Nayeem, Akbar, Sheriff, Steven, Camac, Daniel M., Ramamurthy, Vidyhashankar, Morin, Paul E., Zebo, Rachel, Taylor, Joseph R., Morgan, Nathan N., Ponticiello, Randolph P., Harrity, Thomas, Apedo, Atsu, Golla, Rajasree, Seethala, Ramakrishna, Wang, Mengmeng, Harper, Timothy W., Sleczka, Bogdan G., He, Bin, Kirby, Mark, Leahy, David K., Li, Jianqing, Hanson, Ronald L., Guo, Zhiwei, Li, Yi-Xin, DiMarco, John D., Scaringe, Raymond, Maxwell, Brad, Moulin, Frederick, Barrish, Joel C., Gordon, David A., Robl, Jeffrey A.
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
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Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes
Brigance, Robert P., Meng, Wei, Fura, Aberra, Harrity, Thomas, Wang, Aiying, Zahler, Robert, Kirby, Mark S., Hamann, Lawrence G.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Discovery of Clinical Candidate 2‑((2S,6S)‑2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3′-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor
Ye, Xiang-Yang, Chen, Stephanie Y, Wu, Shung, Yoon, David S, Wang, Haixia, Hong, Zhenqiu, O’Connor, Stephen P, Li, Jun, Li, James J, Kennedy, Lawrence J, Walker, Steven J, Nayeem, Akbar, Sheriff, Steven, Camac, Daniel M, Ramamurthy, Vidyhashankar, Morin, Paul E, Zebo, Rachel, Taylor, Joseph R, Morgan, Nathan N, Ponticiello, Randolph P, Harrity, Thomas, Apedo, Atsu, Golla, Rajasree, Seethala, Ramakrishna, Wang, Mengmeng, Harper, Timothy W, Sleczka, Bogdan G, He, Bin, Kirby, Mark, Leahy, David K, Li, Jianqing, Hanson, Ronald L, Guo, Zhiwei, Li, Yi-Xin, DiMarco, John D, Scaringe, Raymond, Maxwell, Brad, Moulin, Frederick, Barrish, Joel C, Gordon, David A, Robl, Jeffrey A
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
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Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists
Zhang, Hao, Ding, Charles Z., Lai, Zhi, Chen, Sean S., Devasthale, Pratik, Herpin, Tim, Morton, George, Qu, Fucheng, Ryono, Denis, Smirk, Rebecca, Wang, Wei, Wu, Shung, Ye, Xiang-Xang, Li, Yi-Xin, Apedo, Atsu, Farrelly, Dennis, Wang, Tao, Gu, Liqun, Morgan, Nathan, Flynn, Neil, Chu, Cuixia, Kunselman, Lori, Lippy, Jonathan, Locke, Kenneth, O’Malley, Kevin, Harrity, Thomas, Cap, Michael, Zhang, Lisa, Hosagrahara, Vinayak, Kadiyala, Pathanjali, Xu, Carrie, Doweyko, Arthur M., Zahler, Robert, Hariharan, Narayanan, Cheng, Peter T.W.
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
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Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors
Meng, Wei, Brigance, Robert P, Chao, Hannguang J, Fura, Aberra, Harrity, Thomas, Marcinkeviciene, Jovita, O’Connor, Stephen P, Tamura, James K, Xie, Dianlin, Zhang, Yaqun, Klei, Herbert E, Kish, Kevin, Weigelt, Carolyn A, Turdi, Huji, Wang, Aiying, Zahler, Robert, Kirby, Mark S, Hamann, Lawrence G
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
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Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)
Li, Jun, Kennedy, Lawrence J, Walker, Steven J, Wang, Haixia, Li, James J, Hong, Zhenqiu, O’Connor, Stephen P, Ye, Xiang-yang, Chen, Stephanie, Wu, Shung, Yoon, David S, Nayeem, Akbar, Camac, Daniel M, Ramamurthy, Vidhyashankar, Morin, Paul E, Sheriff, Steven, Wang, Mengmeng, Harper, Timothy W, Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P, Morgan, Nathan N, Taylor, Joseph R, Zebo, Rachel, Maxwell, Brad, Moulin, Frederick, Gordon, David A, Robl, Jeffrey A
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
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Design and Synthesis of N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with Efficacious Glucose and Lipid-Lowering Activities
Devasthale, Pratik V, Chen, Sean, Jeon, Yoon, Qu, Fucheng, Shao, Chunning, Wang, Wei, Zhang, Hao, Cap, Michael, Farrelly, Dennis, Golla, Rajasree, Grover, Gary, Harrity, Thomas, Ma, Zhengping, Moore, Lisa, Ren, Jimmy, Seethala, Ramakrishna, Cheng, Lin, Sleph, Paul, Sun, Wei, Tieman, Aaron, Wetterau, John R, Doweyko, Arthur, Chandrasena, Gamini, Chang, Shu Y, Humphreys, W. Griffith, Sasseville, Vito G, Biller, Scott A, Ryono, Denis E, Selan, Fred, Hariharan, Narayanan, Cheng, Peter T. W
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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