PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis
Wang, Qinglan, Boshoff, Helena I M, Harrison, Justin R, Ray, Peter C, Green, Simon R, Wyatt, Paul G, Barry, 3rd, Clifton E
Published in Science (American Association for the Advancement of Science) (06.03.2020)
Published in Science (American Association for the Advancement of Science) (06.03.2020)
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Journal Article
Progress in high-power and high-intensity structured light
Harrison, Justin, Naidoo, Darryl, Forbes, Andrew, Dudley, Angela
Published in Advances in physics: X (31.12.2024)
Published in Advances in physics: X (31.12.2024)
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Journal Article
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N‑Myristoyltransferase Inhibitors
Harrison, Justin R, Brand, Stephen, Smith, Victoria, Robinson, David A, Thompson, Stephen, Smith, Alasdair, Davies, Kenneth, Mok, Ngai, Torrie, Leah S, Collie, Iain, Hallyburton, Irene, Norval, Suzanne, Simeons, Frederick R. C, Stojanovski, Laste, Frearson, Julie A, Brenk, Ruth, Wyatt, Paul G, Gilbert, Ian H, Read, Kevin D
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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Journal Article
Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease
Harrison, Justin R, Sarkar, Sandipan, Hampton, Shahienaz, Riley, Jennifer, Stojanovski, Laste, Sahlberg, Christer, Appelqvist, Pia, Erath, Jessey, Mathan, Vinodhini, Rodriguez, Ana, Kaiser, Marcel, Pacanowska, Dolores Gonzalez, Read, Kevin D, Johansson, Nils Gunnar, Gilbert, Ian H
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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Journal Article
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis
Smith, Alasdair, Wall, Richard J, Patterson, Stephen, Rowan, Tim, Rico Vidal, Eva, Stojanovski, Laste, Huggett, Margaret, Hampton, Shahienaz E, Thomas, Michael G, Corpas Lopez, Victoriano, Gillingwater, Kirsten, Duke, Jeff, Napier, Grant, Peter, Rose, Vitouley, Hervé S, Harrison, Justin R, Milne, Rachel, Jeacock, Laura, Baker, Nicola, Davis, Susan H, Simeons, Frederick, Riley, Jennifer, Horn, David, Brun, Reto, Zuccotto, Fabio, Witty, Michael J, Wyllie, Susan, Read, Kevin D, Gilbert, Ian H
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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Journal Article
Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma brucei N‑Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis
Brand, Stephen, Norcross, Neil R, Thompson, Stephen, Harrison, Justin R, Smith, Victoria C, Robinson, David A, Torrie, Leah S, McElroy, Stuart P, Hallyburton, Irene, Norval, Suzanne, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick R. C, van Aalten, Daan, Frearson, Julie A, Brenk, Ruth, Fairlamb, Alan H, Ferguson, Michael A. J, Wyatt, Paul G, Gilbert, Ian H, Read, Kevin D
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Journal Article
Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors
Brand, Stephen, Cleghorn, Laura A. T, McElroy, Stuart P, Robinson, David A, Smith, Victoria C, Hallyburton, Irene, Harrison, Justin R, Norcross, Neil R, Spinks, Daniel, Bayliss, Tracy, Norval, Suzanne, Stojanovski, Laste, Torrie, Leah S, Frearson, Julie A, Brenk, Ruth, Fairlamb, Alan H, Ferguson, Michael A. J, Read, Kevin D, Wyatt, Paul G, Gilbert, Ian H
Published in Journal of medicinal chemistry (12.01.2012)
Published in Journal of medicinal chemistry (12.01.2012)
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Journal Article
N‑Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus
Fang, Wenxia, Robinson, David A, Raimi, Olawale G, Blair, David E, Harrison, Justin R, Lockhart, Deborah E. A, Torrie, Leah S, Ruda, Gian Filippo, Wyatt, Paul G, Gilbert, Ian H, van Aalten, Daan M. F
Published in ACS chemical biology (19.06.2015)
Published in ACS chemical biology (19.06.2015)
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Journal Article
Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS
Torrie, Leah S, Wyllie, Susan, Spinks, Daniel, Oza, Sandra L, Thompson, Stephen, Harrison, Justin R, Gilbert, Ian H, Wyatt, Paul G, Fairlamb, Alan H, Frearson, Julie A
Published in The Journal of biological chemistry (25.12.2009)
Published in The Journal of biological chemistry (25.12.2009)
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Journal Article
2‑Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization
Murugesan, Dinakaran, Ray, Peter C., Bayliss, Tracy, Prosser, Gareth A., Harrison, Justin R., Green, Kirsteen, Soares de Melo, Candice, Feng, Tzu-Shean, Street, Leslie J., Chibale, Kelly, Warner, Digby F., Mizrahi, Valerie, Epemolu, Ola, Scullion, Paul, Ellis, Lucy, Riley, Jennifer, Shishikura, Yoko, Ferguson, Liam, Osuna-Cabello, Maria, Read, Kevin D., Green, Simon R., Lamprecht, Dirk A., Finin, Peter M., Steyn, Adrie J. C., Ioerger, Thomas R., Sacchettini, Jim, Rhee, Kyu Y., Arora, Kriti, Barry, Clifton E., Wyatt, Paul G., Boshoff, Helena I. M.
Published in ACS infectious diseases (08.06.2018)
Published in ACS infectious diseases (08.06.2018)
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Journal Article
Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi
Herrera, Linda J, Brand, Stephen, Santos, Andres, Nohara, Lilian L, Harrison, Justin, Norcross, Neil R, Thompson, Stephen, Smith, Victoria, Lema, Carolina, Varela-Ramirez, Armando, Gilbert, Ian H, Almeida, Igor C, Maldonado, Rosa A
Published in PLoS neglected tropical diseases (29.04.2016)
Published in PLoS neglected tropical diseases (29.04.2016)
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Journal Article
Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors
Spinks, Daniel, Torrie, Leah S., Thompson, Stephen, Harrison, Justin R., Frearson, Julie A., Read, Kevin D., Fairlamb, Alan H., Wyatt, Paul G., Gilbert, Ian H.
Published in ChemMedChem (02.01.2012)
Published in ChemMedChem (02.01.2012)
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Journal Article
Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis
Brand, Stephen, Norcross, Neil R, Thompson, Stephen, Harrison, Justin R, Smith, Victoria C, Robinson, David A, Torrie, Leah S, McElroy, Stuart P, Hallyburton, Irene, Norval, Suzanne, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick RC, van Aalten, Daan, Frearson, Julie A, Brenk, Ruth, Fairlamb, Alan H, Ferguson, Michael AJ, Wyatt, Paul G, Gilbert, Ian H, Read, Kevin D
Published in Journal of medicinal chemistry (20.11.2014)
Published in Journal of medicinal chemistry (20.11.2014)
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Journal Article
Synthesis of sparteine-like chiral diamines and evaluation in the enantioselective lithiation-substitution of N-(tert-butoxycarbonyl)pyrrolidine
Hermet, JPR, Porter, DW, Dearden, MJ, Harrison, Koplin, T, O'Brien, P, Parmene, J, Tyurin, Whitwood, AC, Gilday, J, Smith, NM
Published in Organic & biomolecular chemistry (21.11.2003)
Published in Organic & biomolecular chemistry (21.11.2003)
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Journal Article
A Concise Synthesis of the Octalactins
O'Sullivan, Paul T, Buhr, Wilm, Fuhry, Mary Ann M, Harrison, Justin R, Davies, John E, Feeder, Neil, Marshall, David R, Burton, Jonathan W, Holmes, Andrew B
Published in Journal of the American Chemical Society (25.02.2004)
Published in Journal of the American Chemical Society (25.02.2004)
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Journal Article