Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification
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Published in Annals of the rheumatic diseases (01.11.2016)
Published in Annals of the rheumatic diseases (01.11.2016)
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Whole‐Exome Sequencing Reveals Overlap Between Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis and Familial Hemophagocytic Lymphohistiocytosis
Kaufman, Kenneth M., Linghu, Bolan, Szustakowski, Joseph D., Husami, Ammar, Yang, Fan, Zhang, Kejian, Filipovich, Alexandra H., Fall, Ndate, Harley, John B., Nirmala, N. R., Grom, Alexei A.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.12.2014)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.12.2014)
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SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression
Hou, Guojun, Harley, Isaac T W, Lu, Xiaoming, Zhou, Tian, Xu, Ning, Yao, Chao, Qin, Yuting, Ouyang, Ye, Ma, Jianyang, Zhu, Xinyi, Yu, Xiang, Xu, Hong, Dai, Dai, Ding, Huihua, Yin, Zhihua, Ye, Zhizhong, Deng, Jun, Zhou, Mi, Tang, Yuanjia, Namjou, Bahram, Guo, Ya, Weirauch, Matthew T, Kottyan, Leah C, Harley, John B, Shen, Nan
Published in Nature communications (08.01.2021)
Published in Nature communications (08.01.2021)
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MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis
Pan, Wen, Zhu, Shu, Dai, Dai, Liu, Zheng, Li, Dan, Li, Bin, Gagliani, Nicola, Zheng, Yunjiang, Tang, Yuanjia, Weirauch, Matthew T, Chen, Xiaoting, Zhu, Wei, Wang, Yue, Chen, Bo, Qian, Youcun, Chen, Yingxuan, Fang, Jingyuan, Herbst, Ronald, Richman, Laura, Jallal, Bahija, Harley, John B, Flavell, Richard A, Yao, Yihong, Shen, Nan
Published in Nature communications (12.05.2015)
Published in Nature communications (12.05.2015)
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Global discovery of lupus genetic risk variant allelic enhancer activity
Lu, Xiaoming, Chen, Xiaoting, Forney, Carmy, Donmez, Omer, Miller, Daniel, Parameswaran, Sreeja, Hong, Ted, Huang, Yongbo, Pujato, Mario, Cazares, Tareian, Miraldi, Emily R, Ray, John P, de Boer, Carl G, Harley, John B, Weirauch, Matthew T, Kottyan, Leah C
Published in Nature communications (12.03.2021)
Published in Nature communications (12.03.2021)
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Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks
Pelikan, Richard C, Kelly, Jennifer A, Fu, Yao, Lareau, Caleb A, Tessneer, Kandice L, Wiley, Graham B, Wiley, Mandi M, Glenn, Stuart B, Harley, John B, Guthridge, Joel M, James, Judith A, Aryee, Martin J, Montgomery, Courtney, Gaffney, Patrick M
Published in Nature communications (25.07.2018)
Published in Nature communications (25.07.2018)
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T-bet + CD11c + B cells are critical for antichromatin immunoglobulin G production in the development of lupus
Liu, Ya, Zhou, Shiyu, Qian, Jie, Wang, Yan, Yu, Xiang, Dai, Dai, Dai, Min, Wu, Lingling, Liao, Zhuojun, Xue, Zhixin, Wang, Jiehua, Hou, Goujun, Ma, Jianyang, Harley, John B, Tang, Yuanjia, Shen, Nan
Published in Arthritis research & therapy (05.10.2017)
Published in Arthritis research & therapy (05.10.2017)
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In Vivo Therapeutic Success of MicroRNA‐155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage
Zhou, Shiyu, Wang, Yan, Meng, Yao, Xiao, Chunyuan, Liu, Zheng, Brohawn, Philip, Higgs, Brandon W., Jallal, Bahija, Jia, Qian, Qu, Bo, Huang, Xinfang, Tang, Yuanjia, Yao, Yihong, Harley, John B., Shen, Nan
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2016)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2016)
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Identification of Four Novel Loci in Asthma in European American and African American Populations
Almoguera, Berta, Vazquez, Lyam, Mentch, Frank, Connolly, John, Pacheco, Jennifer A, Sundaresan, Agnes S, Peissig, Peggy L, Linneman, James G, McCarty, Catherine A, Crosslin, David, Carrell, David S, Lingren, Todd, Namjou-Khales, Bahram, Harley, John B, Larson, Eric, Jarvik, Gail P, Brilliant, Murray, Williams, Marc S, Kullo, Iftikhar J, Hysinger, Erik B, Sleiman, Patrick M A, Hakonarson, Hakon
Published in American journal of respiratory and critical care medicine (15.02.2017)
Published in American journal of respiratory and critical care medicine (15.02.2017)
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A High Prevalence of Anti-EBNA1 Heteroantibodies in Systemic Lupus Erythematosus (SLE) Supports Anti-EBNA1 as an Origin for SLE Autoantibodies
Laurynenka, Viktoryia, Ding, Lili, Kaufman, Kenneth M, James, Judith A, Harley, John B
Published in Frontiers in immunology (17.02.2022)
Published in Frontiers in immunology (17.02.2022)
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Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery
Zhou, Tian, Zhu, Xinyi, Ye, Zhizhong, Wang, Yong-Fei, Yao, Chao, Xu, Ning, Zhou, Mi, Ma, Jianyang, Qin, Yuting, Shen, Yiwei, Tang, Yuanjia, Yin, Zhihua, Xu, Hong, Zhang, Yutong, Zang, Xiaoli, Ding, Huihua, Yang, Wanling, Guo, Ya, Harley, John B, Namjou, Bahram, Kaufman, Kenneth M, Kottyan, Leah C, Weirauch, Matthew T, Hou, Guojun, Shen, Nan
Published in Nature communications (06.04.2022)
Published in Nature communications (06.04.2022)
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Complete Tracheal Ring Deformity. A Translational Genomics Approach to Pathogenesis
Sinner, Debora I, Carey, Brenna, Zgherea, Daniela, Kaufman, K M, Leesman, Lauren, Wood, Robert E, Rutter, Michael J, de Alarcon, Alessandro, Elluru, Ravindhra G, Harley, John B, Whitsett, Jeffrey A, Trapnell, Bruce C
Published in American journal of respiratory and critical care medicine (15.11.2019)
Published in American journal of respiratory and critical care medicine (15.11.2019)
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Identification of unique microRNA signature associated with lupus nephritis
Te, Jeannie L, Dozmorov, Igor M, Guthridge, Joel M, Nguyen, Kim L, Cavett, Joshua W, Kelly, Jennifer A, Bruner, Gail R, Harley, John B, Ojwang, Joshua O
Published in PloS one (11.05.2010)
Published in PloS one (11.05.2010)
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Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus
Arbuckle, Melissa R, McClain, Micah T, Rubertone, Mark V, Scofield, R. Hal, Dennis, Gregory J, James, Judith A, Harley, John B
Published in The New England journal of medicine (16.10.2003)
Published in The New England journal of medicine (16.10.2003)
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Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase
Jacob, Chaim O, Eisenstein, Miriam, Dinauer, Mary C, Ming, Wenyu, Liu, Qiang, John, Sutha, Quismorio, Francesco P., Jr, Reiff, Andreas, Myones, Barry L, Kaufman, Kenneth M, McCurdy, Deborah, Harley, John B, Silverman, Earl, Kimberly, Robert P, Vyse, Timothy J, Gaffney, Patrick M, Moser, Kathy L, Klein-Gitelman, Marisa, Wagner-Weiner, Linda, Langefeld, Carl D, Armstrong, Don L, Zidovetzki, Raphael
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2012)
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Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis
Harris, Valerie M, Koelsch, Kristi A, Kurien, Biji T, Harley, Isaac T W, Wren, Jonathan D, Harley, John B, Scofield, R Hal
Published in Frontiers in immunology (21.10.2019)
Published in Frontiers in immunology (21.10.2019)
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Medical Records-Based Genetic Studies of the Complement System
Khan, Atlas, Shang, Ning, Petukhova, Lynn, Zhang, Jun, Shen, Yufeng, Hebbring, Scott J, Moncrieffe, Halima, Kottyan, Leah C, Namjou-Khales, Bahram, Knevel, Rachel, Raychaudhuri, Soumya, Karlson, Elizabeth W, Harley, John B, Stanaway, Ian B, Crosslin, David, Denny, Joshua C, Elkind, Mitchell S V, Gharavi, Ali G, Hripcsak, George, Weng, Chunhua, Kiryluk, Krzysztof
Published in Journal of the American Society of Nephrology (01.08.2021)
Published in Journal of the American Society of Nephrology (01.08.2021)
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