3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential
Younis, Yassir, Douelle, Frederic, Feng, Tzu-Shean, Cabrera, Diego González, Manach, Claire Le, Nchinda, Aloysius T, Duffy, Sandra, White, Karen L, Shackleford, David M, Morizzi, Julia, Mannila, Janne, Katneni, Kasiram, Bhamidipati, Ravi, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Hardick, David, Wittlin, Sergio, Avery, Vicky, Charman, Susan A, Chibale, Kelly
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Characterisation of the binding of [ 3H]methyllycaconitine: a new radioligand for labelling α7-type neuronal nicotinic acetylcholine receptors
Davies, Andrew R.L, Hardick, David J, Blagbrough, Ian S, Potter, Barry V.L, Wolstenholme, Adrian J, Wonnacott, Susan
Published in Neuropharmacology (15.05.1999)
Published in Neuropharmacology (15.05.1999)
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Novel Angular Benzophenazines: Dual Topoisomerase I and Topoisomerase II Inhibitors as Potential Anticancer Agents
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Published in Journal of medicinal chemistry (31.01.2002)
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Nudicauline and Elatine as Potent Norditerpenoid Ligands at Rat Neuronal α-Bungarotoxin Binding Sites: Importance of the 2-(Methylsuccinimido)benzoyl Moiety for Neuronal Nicotinic Acetylcholine Receptor Binding
Hardick, David J, Blagbrough, Ian S, Cooper, Gary, Potter, Barry V. L, Critchley, Trevor, Wonnacott, Susan
Published in Journal of medicinal chemistry (22.11.1996)
Published in Journal of medicinal chemistry (22.11.1996)
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Novel Reduced Benzo[j]fluoranthen-3-ones from Cladosporium cf. cladosporioides with Cytokine Production and Tyrosine Kinase Inhibitory Properties
WRIGLEY, STEPHEN K., AINSWORTH, A. MARTYN, KAU, DAVID A., MARTIN, STEVEN M., BAHL, SANGEETA, TANG, JENNY S., HARDICK, DAVID J., RAWLINS, PHILIP, SADHEGHI, ROYA, MOORE, MICHAEL
Published in Journal of antibiotics (2001)
Published in Journal of antibiotics (2001)
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Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity
Guirguis, Andrew A., Ofir-Rosenfeld, Yaara, Knezevic, Kathy, Blackaby, Wesley, Hardick, David, Chan, Yih-Chih, Motazedian, Ali, Gillespie, Andrea, Vassiliadis, Dane, Lam, Enid Y.N., Tran, Kevin, Andrews, Byron, Harbour, Michael E., Vasiliauskaite, Lina, Saunders, Claire J., Tsagkogeorga, Georgia, Azevedo, Aleksandra, Obacz, Joanna, Pilka, Ewa S., Carkill, Marie, MacPherson, Laura, Wainwright, Elanor N., Liddicoat, Brian, Blyth, Benjamin J., Albertella, Mark R., Rausch, Oliver, Dawson, Mark A.
Published in Cancer discovery (05.10.2023)
Published in Cancer discovery (05.10.2023)
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[ 3H]-Methyllycaconitine: a high affinity radioligand that labels invertebrate nicotinic acetylcholine receptors
Lind, Robert J, Hardick, David J, Blagbrough, Ian S, Potter, Barry V.L, Wolstenholme, Adrian J, Davies, Andrew R.L, Clough, Martin S, Earley, Fergus G.P, E. Reynolds, Stuart, Wonnacott, Susan
Published in Insect biochemistry and molecular biology (27.04.2001)
Published in Insect biochemistry and molecular biology (27.04.2001)
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METTL3 저해제로서의 폴리헤테로환식 화합물
SHEPHERD JON, THOMAS ELIZABETH JANE, BLACKABY WESLEY PETER, BUBERT CHRISTIAN, BROOKFIELD FREDERICK ARTHUR, HARDICK DAVID JAMES, RIDGILL MARK PETER
Year of Publication 12.08.2022
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Year of Publication 12.08.2022
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Inhibition of METTL3 results in a cell-intrinsic interferon response that enhances anti-tumour immunity
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Published in Cancer discovery (07.08.2023)
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URBANO MARIANGELA, JONES ROBERT M, KNIGHT CHRIS, CHAMBERS MARK, BRANDT GARY, TIERNEY JASON, LOCK CHRIS, HARDICK DAVID
Year of Publication 13.05.2020
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Year of Publication 13.05.2020
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A comparative study of fragment screening methods on the p38α kinase: new methods, new insights
Pollack, Scott J., Beyer, Kim S., Lock, Christopher, Müller, Ilka, Sheppard, David, Lipkin, Mike, Hardick, David, Blurton, Peter, Leonard, Philip M., Hubbard, Paul A., Todd, Daniel, Richardson, Christine M., Ahrens, Thomas, Baader, Manuel, Hafenbradl, Doris O., Hilyard, Kate, Bürli, Roland W.
Published in Journal of computer-aided molecular design (01.07.2011)
Published in Journal of computer-aided molecular design (01.07.2011)
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A comparative study of fragment screening methods on the p38[alpha] kinase: new methods, new insights
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Published in Journal of computer-aided molecular design (01.07.2011)
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Ridgill, Mark Peter, Bubert, Christian, Canelli, Tommaso, Hardick, David James
Year of Publication 22.08.2024
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Year of Publication 22.08.2024
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Structure–activity relationships for analogues of the phenazine-based dual topoisomerase I/II inhibitor XR11576
Wang, Shouming, Miller, Warren, Milton, John, Vicker, Nigel, Stewart, Alistair, Charlton, Peter, Mistry, Prakash, Hardick, David, Denny, William A
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
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RIDGILL, Mark Peter, BUBERT, Christian, CANELLI, Tommaso, HARDICK, David James
Year of Publication 08.12.2022
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Vasopressin receptor antagonists and products and methods related thereto
Tierney, Jason, Urbano, Mariangela, Hardick, David, Knight, Chris, Jones, Robert, Chambers, Mark, Lock, Chris, Brandt, Gary
Year of Publication 26.04.2024
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Year of Publication 26.04.2024
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Urbano, Mariangela, Tierney, Jason, Jones, Robert M, Hardick, David, Knight, Chris, Brandt, Gary
Year of Publication 02.01.2024
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