Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Harden, T. Kendall, Kadl, Alexandra, Ostankovich, Marina, Lazarowski, Eduardo R, Lysiak, Jeffrey J, Walk, Scott F, Ravichandran, Kodi S, Elliott, Michael R, Woodson, Robin I, Park, Daeho, Chekeni, Faraaz B, Trampont, Paul C, Sharma, Poonam, Leitinger, Norbert
Published in Nature (London) (10.09.2009)
Published in Nature (London) (10.09.2009)
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Journal Article
Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations
Hajicek, Nicole, Keith, Nicholas C, Siraliev-Perez, Edhriz, Temple, Brenda Rs, Huang, Weigang, Zhang, Qisheng, Harden, T Kendall, Sondek, John
Published in eLife (31.12.2019)
Published in eLife (31.12.2019)
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Journal Article
The experimental power of FR900359 to study Gq-regulated biological processes
Schrage, Ramona, Schmitz, Anna-Lena, Gaffal, Evelyn, Annala, Suvi, Kehraus, Stefan, Wenzel, Daniela, Büllesbach, Katrin M., Bald, Tobias, Inoue, Asuka, Shinjo, Yuji, Galandrin, Ségolène, Shridhar, Naveen, Hesse, Michael, Grundmann, Manuel, Merten, Nicole, Charpentier, Thomas H., Martz, Matthew, Butcher, Adrian J., Slodczyk, Tanja, Armando, Sylvain, Effern, Maike, Namkung, Yoon, Jenkins, Laura, Horn, Velten, Stößel, Anne, Dargatz, Harald, Tietze, Daniel, Imhof, Diana, Galés, Céline, Drewke, Christel, Müller, Christa E., Hölzel, Michael, Milligan, Graeme, Tobin, Andrew B., Gomeza, Jesús, Dohlman, Henrik G., Sondek, John, Harden, T. Kendall, Bouvier, Michel, Laporte, Stéphane A., Aoki, Junken, Fleischmann, Bernd K., Mohr, Klaus, König, Gabriele M., Tüting, Thomas, Kostenis, Evi
Published in Nature communications (14.12.2015)
Published in Nature communications (14.12.2015)
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Journal Article
Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17
Qi, Ai-Dong, Harden, T Kendall, Nicholas, Robert A
Published in The Journal of pharmacology and experimental therapeutics (01.10.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2013)
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Journal Article
Kinetic Scaffolding Mediated by a Phospholipase C-β and Gq Signaling Complex
Waldo, Gary L, Ricks, Tiffany K, Hicks, Stephanie N, Cheever, Matthew L, Kawano, Takeharu, Tsuboi, Kazuhito, Wang, Xiaoyue, Montell, Craig, Kozasa, Tohru, Sondek, John, Harden, T. Kendall
Published in Science (American Association for the Advancement of Science) (12.11.2010)
Published in Science (American Association for the Advancement of Science) (12.11.2010)
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Journal Article
Structure-Based Design of 3‑(4-Aryl‑1H‑1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists
Junker, Anna, Balasubramanian, Ramachandran, Ciancetta, Antonella, Uliassi, Elisa, Kiselev, Evgeny, Martiriggiano, Chiara, Trujillo, Kevin, Mtchedlidze, Giorgi, Birdwell, Leah, Brown, Kyle A, Harden, T. Kendall, Jacobson, Kenneth A
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Journal Article
Regulation of phospholipase C isozymes by ras superfamily GTPases
Harden, T Kendall, Sondek, John
Published in Annual review of pharmacology and toxicology (01.01.2006)
Published in Annual review of pharmacology and toxicology (01.01.2006)
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Journal Article
Mechanism of Activation and Inactivation of Gq/Phospholipase C-β Signaling Nodes
Harden, T. Kendall, Waldo, Gary L, Hicks, Stephanie N, Sondek, John
Published in Chemical reviews (12.10.2011)
Published in Chemical reviews (12.10.2011)
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Journal Article
UDP-glucose promotes neutrophil recruitment in the lung
Sesma, Juliana I., Weitzer, Clarissa D., Livraghi-Butrico, Alessandra, Dang, Hong, Donaldson, Scott, Alexis, Neil E., Jacobson, Kenneth A., Harden, T. Kendall, Lazarowski, Eduardo R.
Published in Purinergic signalling (01.12.2016)
Published in Purinergic signalling (01.12.2016)
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Journal Article
The UDP-sugar-sensing P2Y14 receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils
Sesma, Juliana I., Kreda, Silvia M., Steinckwich-Besancon, Natacha, Dang, Hong, García-Mata, Rafael, Harden, T. Kendall, Lazarowski, Eduardo R.
Published in American Journal of Physiology: Cell Physiology (01.09.2012)
Published in American Journal of Physiology: Cell Physiology (01.09.2012)
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Journal Article
Crystal structure of Rac1 bound to its effector phospholipase C-β2
Sondek, John, Jezyk, Mark R, Snyder, Jason T, Gershberg, Svetlana, Worthylake, David K, Harden, T Kendall
Published in Nature structural & molecular biology (01.12.2006)
Published in Nature structural & molecular biology (01.12.2006)
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Journal Article
Quantification of Gi-Mediated Inhibition of Adenylyl Cyclase Activity Reveals That UDP Is a Potent Agonist of the Human P2Y14 Receptor
Carter, Rhonda L, Fricks, Ingrid P, Barrett, Matthew O, Burianek, Lauren E, Zhou, Yixing, Ko, Hyojin, Das, Arijit, Jacobson, Kenneth A, Lazarowski, Eduardo R, Harden, T Kendall
Published in Molecular pharmacology (01.12.2009)
Published in Molecular pharmacology (01.12.2009)
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Journal Article
Aberrant Receptor Internalization and Enhanced FRS2-dependent Signaling Contribute to the Transforming Activity of the Fibroblast Growth Factor Receptor 2 IIIb C3 Isoform
Cha, Jiyoung Y., Maddileti, Savitri, Mitin, Natalia, Harden, T.Kendall, Der, Channing J.
Published in The Journal of biological chemistry (06.03.2009)
Published in The Journal of biological chemistry (06.03.2009)
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Journal Article
Phospholipase C isozymes as effectors of Ras superfamily GTPases
Harden, T. Kendall, Hicks, Stephanie N., Sondek, John
Published in Journal of lipid research (01.04.2009)
Published in Journal of lipid research (01.04.2009)
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Journal Article
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms
Healy, Kevin D., Hodgson, Louis, Kim, Tai-Young, Shutes, Adam, Maddileti, Savitri, Juliano, Rudolph L., Hahn, Klaus M., Harden, T. Kendall, Bang, Yung-Jue, Der, Channing J.
Published in Molecular carcinogenesis (01.05.2008)
Published in Molecular carcinogenesis (01.05.2008)
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Journal Article
Synthesis and P2Y receptor activity of nucleoside 5′-phosphonate derivatives
Cosyn, Liesbet, Calenbergh, Serge Van, Joshi, Bhalchandra V., Ko, Hyojin, Carter, Rhonda L., Kendall Harden, T., Jacobson, Kenneth A.
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
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Journal Article