Targeting the p300/CBP Axis in Lethal Prostate Cancer
Welti, Jonathan, Sharp, Adam, Brooks, Nigel, Yuan, Wei, McNair, Christopher, Chand, Saswati N, Pal, Abhijit, Figueiredo, Ines, Riisnaes, Ruth, Gurel, Bora, Rekowski, Jan, Bogdan, Denisa, West, William, Young, Barbara, Raja, Meera, Prosser, Amy, Lane, Jordan, Thomson, Stuart, Worthington, Jenny, Onions, Stuart, Shannon, Jonathan, Paoletta, Silvia, Brown, Richard, Smyth, Don, Harbottle, Gareth W, Gil, Veronica S, Miranda, Susana, Crespo, Mateus, Ferreira, Ana, Pereira, Rita, Tunariu, Nina, Carreira, Suzanne, Neeb, Antje J, Ning, Jian, Swain, Amanda, Taddei, David, Schiewer, Matthew J, Knudsen, Karen E, Pegg, Neil, de Bono, Johann S
Published in Cancer discovery (01.05.2021)
Published in Cancer discovery (01.05.2021)
Get full text
Journal Article
Convergent Asymmetric Synthesis of Two Complex TRPV1 Antagonists
Butcher, Kenneth J, Denton, Steven M, Field, Stuart E, Gillmore, Adam T, Harbottle, Gareth W, Howard, Roger M, Laity, Daniel A, Ngono, Christian J, Pibworth, Benjamin A
Published in Organic process research & development (16.09.2011)
Published in Organic process research & development (16.09.2011)
Get full text
Journal Article
In vitro and in vivo SAR of pyrido[3,4- d]pyramid-4-ylamine based mGluR1 antagonists
Mantell, Simon J., Gibson, Karl R., Osborne, Simon A., Maw, Graham N., Rees, Huw, Dodd, Peter G., Greener, Ben, Harbottle, Gareth W., Million, William A., Poinsard, Cedric, England, Steven, Carnell, Pauline, Betts, Alison M., Monhemius, Russell, Prime, Rebecca L.
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Get full text
Journal Article
Microwave-assisted synthesis of mGluR1 ligands: carbon, nitrogen and oxygen linked derivatives of pyrido[3,4- d]pyrimidin-4-ylamines
Harbottle, Gareth W., Feeder, Neil, Gibson, Karl R., Glossop, Mel, Maw, Graham N., Million, William A., Morel, Florence F., Osborne, Simon, Poinsard, Cedric
Published in Tetrahedron letters (11.06.2007)
Published in Tetrahedron letters (11.06.2007)
Get full text
Journal Article
Structure–activity relationships of novel non-competitive mGluR1 antagonists: A potential treatment for chronic pain
Owen, Dafydd R., Dodd, Peter G., Gayton, Simon, Greener, Ben S., Harbottle, Gareth W., Mantell, Simon J., Maw, Graham N., Osborne, Simon A., Rees, Huw, Ringer, Tracy J., Rodriguez-Lens, Margarita, Smith, Graham F.
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Get full text
Journal Article
Cycloaddition of Chiral tert-Butanesulfinimines with Trimethylenemethane
Procopiou, George, Lewis, William, Harbottle, Gareth, Stockman, Robert A
Published in Organic letters (19.04.2013)
Published in Organic letters (19.04.2013)
Get full text
Journal Article
Characterisation of CCS1477: A novel small molecule inhibitor of p300/CBP for the treatment of castration resistant prostate cancer
Pegg, Neil, Brooks, Nigel, Worthington, Jenny, Young, Barbara, Prosser, Amy, Lane, Jordan, Taddei, David, Brown, Richard, Harbottle, Gareth, Shannon, Jonathan, Paoletta, Silvia, Knudsen, Karen E.
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
Get full text
Journal Article
Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B
Procopiou, George, Aggarwal, Pooja, Newton, Annabella F., Richards, David, Mellor, Ian R., Harbottle, Gareth, Stockman, Robert A.
Published in Chemical communications (Cambridge, England) (18.12.2014)
Published in Chemical communications (Cambridge, England) (18.12.2014)
Get full text
Journal Article
Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B′Electronic supplementary information (ESI) available. See DOI: 10.1039/c4cc07287a
Procopiou, George, Aggarwal, Pooja, Newton, Annabella F, Richards, David, Mellor, Ian R, Harbottle, Gareth, Stockman, Robert A
Year of Publication 11.11.2014
Year of Publication 11.11.2014
Get full text
Journal Article
Targeting p300/CBP in lethal prostate cancer
Welti, Jonathan, Sharp, Adam, Brooks, Nigel, Yuan, Wei, McNair, Christopher, Chand, Saswati N., Pal, Abhijit, Figueiredo, Ines, Riisnaes, Ruth, Gurel, Bora, Rekowski, Jan, Bogdan, Denisa, West, William, Young, Barbara, Raja, Meera, Prosser, Amy, Lane, Jordan, Thomson, Stuart, Worthington, Jenny, Onions, Stuart, Shannon, Jonathan, Paoletta, Silvia, Brown, Richard, Smyth, Don, Harbottle, Gareth W., Gil, Veronica S., Miranda, Susana, Crespo, Mateus, Ferreira, Ana, Pereira, Rita, Tunariu, Nina, Carreira, Suzanne, Neeb, Antje J., Ning, Jian, Swain, Amanda, Taddei, David, Schiewer, Matthew J., Knudsen, Karen E., Pegg, Neil, de Bono, Johann S.
Published in Cancer discovery (11.01.2021)
Published in Cancer discovery (11.01.2021)
Get full text
Journal Article
p300 및/또는 CBP의 조절제를 제조하는 방법
TADDEI DAVID MICHEL ADRIEN, TREVORROW JONATHAN, BAGULEY PAUL, HARBOTTLE GARETH, WOOD DAVID, LINDLEY COLIN, MADELEY JOHN PAUL, MOREY JAMES VAUGHAN, GILBERT DONALD ALAN
Year of Publication 11.01.2021
Get full text
Year of Publication 11.01.2021
Patent
Selective fluorination of 1-hydroxyisoquinolines using Selectfluor
Price, David A., James, Kim, Osborne, Simon, Harbottle, Gareth W.
Published in Tetrahedron letters (08.10.2007)
Published in Tetrahedron letters (08.10.2007)
Get full text
Journal Article
약학적 화합물
TADDEI DAVID MICHEL ADRIEN, PEGG NEIL ANTHONY, BROWN RICHARD JAMES, SHANNON JONATHAN, SMYTH DON, PAOLETTA SILVIA, HARBOTTLE GARETH, ONIONS STUART THOMAS
Year of Publication 28.06.2019
Get full text
Year of Publication 28.06.2019
Patent
UREA DERIVATIVES USEFUL AS KINASE INHIBITORS
HASIMBEGOVIC VEDRAN, FYFE MATTHEW COLIN THOR, HARBOTTLE GARETH WILLIAM, THOM STEPHEN MALCOLM, SAMBROOK SMITH COLIN, RIGBY AARON, MEGHANI PREMJI, BAKER THOMAS MATTHEW
Year of Publication 10.12.2015
Get full text
Year of Publication 10.12.2015
Patent
Pharmaceutical compounds
Shannon, Jonathan, Paoletta, Silvia, Pegg, Neil Anthony, Qin, Ting, Harbottle, Gareth, Taddei, David Michel Adrien
Year of Publication 17.02.2022
Get full text
Year of Publication 17.02.2022
Patent
PHARMACEUTICAL COMPOUNDS
PAOLETTA, Silvia, TADDEI, David Michel Adrien, QIN, Ting, PEGG, Neil Anthony, SHANNON, Jonathan, HARBOTTLE, Gareth
Year of Publication 28.04.2021
Get full text
Year of Publication 28.04.2021
Patent
PHARMACEUTICAL COMPOUNDS
PAOLETTA, Silvia, TADDEI, David Michel Adrien, PEGG, Neil Anthony, ONIONS, Stuart Thomas, SHANNON, Jonathan, BROWN, Richard James, HARBOTTLE, Gareth, SMYTH, Don
Year of Publication 26.10.2022
Get full text
Year of Publication 26.10.2022
Patent