Identification of essential genes in cultured mammalian cells using small interfering RNAs
Harborth, J, Elbashir, S M, Bechert, K, Tuschl, T, Weber, K
Published in Journal of cell science (15.12.2001)
Published in Journal of cell science (15.12.2001)
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Journal Article
The mitotic-spindle-associated protein astrin is essential for progression through mitosis
Gruber, Jens, Harborth, Jens, Schnabel, Jörg, Weber, Klaus, Hatzfeld, Mechthild
Published in Journal of cell science (01.11.2002)
Published in Journal of cell science (01.11.2002)
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Journal Article
GAS41, a Highly Conserved Protein in Eukaryotic Nuclei, Binds to NuMA
Harborth, Jens, Weber, Klaus, Osborn, Mary
Published in The Journal of biological chemistry (13.10.2000)
Published in The Journal of biological chemistry (13.10.2000)
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Journal Article
Targeting Lysophosphatidic Acid Receptor 1 (LPAR1) with siRNA-Lipid Nanoparticles (siRNA-LNP) Is a Potential Therapeutic Approach for CKD -Associated Kidney Fibrosis: SA-PO443
Yu, Xing-Xian (Scott), Liu, Yun, Xia, Fengcheng, Quimbo, Alistair Joseph C., Harborth, Jens, Lee, Jingyuan, Clamme, Jean-Pierre
Published in Journal of the American Society of Nephrology (01.11.2023)
Published in Journal of the American Society of Nephrology (01.11.2023)
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Journal Article
A Novel Lipid Nanoparticle NBF-006 Encapsulating Glutathione S-Transferase P siRNA for the Treatment of KRAS-driven Non-small Cell Lung Cancer
Cina, Cima, Majeti, Bharat, O'Brien, Zhihong, Wang, Li, Clamme, Jean Pierre, Adami, Roger, Tsang, Kwok Yin, Harborth, Jens, Ying, Wenbin, Zabludoff, Sonya
Published in Molecular cancer therapeutics (17.10.2024)
Published in Molecular cancer therapeutics (17.10.2024)
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Journal Article
Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing
Harborth, Jens, Elbashir, Sayda M, Vandenburgh, Kim, Manninga, Heiko, Scaringe, Stephen A, Weber, Klaus, Tuschl, Thomas
Published in Antisense & nucleic acid drug development (01.04.2003)
Published in Antisense & nucleic acid drug development (01.04.2003)
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Journal Article
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Tuschl, Thomas, Elbashir, Sayda M, Harborth, Jens, Lendeckel, Winfried, Yalcin, Abdullah, Weber, Klaus
Published in Nature (London) (24.05.2001)
Published in Nature (London) (24.05.2001)
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Journal Article
Abstract 4060: Discovery and preclinical development of KRAS-targeting siRNA therapeutic modality for the treatment of pancreatic cancer
OBrien, Zhihong (Julie), Wang, Li, Cina, Cima, Majeti, Bharat, Chu, James, Wang, Xiaoen, Baclig, Robiel, Lin, James, Ibarra, Jose, Chatterjee, Dhrubamitra, Jin, Jung-Kang, Clamme, Jean-Pierre, Daniels, Jennifer, Wang, Hai, Harborth, Jens, Ying, Wenbin
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Soutschek, Jürgen, Akinc, Akin, Bramlage, Birgit, Charisse, Klaus, Constien, Rainer, Donoghue, Mary, Elbashir, Sayda, Geick, Anke, Hadwiger, Philipp, Harborth, Jens, John, Matthias, Kesavan, Venkitasamy, Lavine, Gary, Pandey, Rajendra K, Racie, Timothy, Rajeev, Kallanthottathil G, Röhl, Ingo, Toudjarska, Ivanka, Wang, Gang, Wuschko, Silvio, Bumcrot, David, Koteliansky, Victor, Limmer, Stefan, Manoharan, Muthiah, Vornlocher, Hans-Peter
Published in Nature (11.11.2004)
Published in Nature (11.11.2004)
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Journal Article
Analysis of gene function in somatic mammalian cells using small interfering RNAs
Elbashir, Sayda M., Harborth, Jens, Weber, Klaus, Tuschl, Thomas
Published in Methods (San Diego, Calif.) (01.02.2002)
Published in Methods (San Diego, Calif.) (01.02.2002)
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Journal Article
Abstract 5918: A novel glutathione S-transferase P (GSTP) siRNA (NDT-05-1040) for the treatment of KRAS-driven non-small cell lung cancer
Cina, Cima, Harborth, Jens, O'Brien, Zhihong, Beltran-Raygoza, Nish, Jin, Jung-kang, Xu, Jessica, Lee, Sang Jun, Tsang, Kwok, Yao, Jiping, Adami, Roger, Zabludoff, Sonya, Ying, Wenbin
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 5917: A novel lipid nanoparticle (NBF-006) encapsulating glutathione S-transferase P (GSTP) siRNA for the treatment of KRAS-driven non-small cell lung cancer
O'Brien, Zhihong, Wang, Li, Majeti, Bharat, Clamme, Jeanpierre, Baclig, Robiel, Chu, James, Fong, Steven, Harborth, Jens, Ibarra, Jose, Yin, Haiqing, Yu, Jing, Zhang, Clayton, Adami, Roger, Zabludoff, Sonya, Ying, Wenbin
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)
DeVincenzo, John, Cehelsky, Jeffrey E., Alvarez, Rene, Elbashir, Sayda, Harborth, Jens, Toudjarska, Iva, Nechev, Lubomir, Murugaiah, Veeravagu, Vliet, Andre Van, Vaishnaw, Akshay K., Meyers, Rachel
Published in Antiviral research (01.03.2008)
Published in Antiviral research (01.03.2008)
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Journal Article
Effect of Clathrin Heavy Chain- and α-Adaptin-specific Small Inhibitory RNAs on Endocytic Accessory Proteins and Receptor Trafficking in HeLa Cells
Hinrichsen, Lars, Harborth, Jens, Andrees, Lars, Weber, Klaus, Ungewickell, Ernst J.
Published in The Journal of biological chemistry (14.11.2003)
Published in The Journal of biological chemistry (14.11.2003)
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Journal Article
Nucleoplasmic LAP2α-Lamin A Complexes Are Required to Maintain a Proliferative State in Human Fibroblasts
Pekovic, Vanja, Harborth, Jens, Broers, Jos L. V., Ramaekers, Frans C. S., van Engelen, Baziel, Lammens, Martin, von Zglinicki, Thomas, Foisner, Roland, Hutchison, Chris, Markiewicz, Ewa
Published in The Journal of cell biology (15.01.2007)
Published in The Journal of cell biology (15.01.2007)
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Journal Article
RNAi-mediated gene silencing in non-human primates
Wheat, Amanda J, Vornlocher, Hans-Peter, Röhl, Ingo, Lam, Kieu, McClintock, Kevin, Koteliansky, Victor, Yaworski, Ed, Jeffs, Lloyd B, MacLachlan, Ian, Soutschek, Jürgen, Toudjarska, Ivanka, Palmer, Lorne R, Heyes, James A, Zedalis, William, Akinc, Akin, Lee, Amy C. H, Bumcrot, David, Manoharan, Muthiah, Judge, Adam D, Racie, Timothy, Shanmugam, Sumi, Sood, Vandana, Seiffert, Stephan, Bramlage, Birgit, Fedoruk, Matthew N, Harborth, Jens, Zimmermann, Tracy S, John, Matthias, Nechev, Lubomir V
Published in Nature (04.05.2006)
Published in Nature (04.05.2006)
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Journal Article
높은 활성 및 감소한 오프 타겟을 위한 SIRNA 구조
HARBORTH JENS, ZHENG JANE, VAISH NARENDRA, CINA CIMA, YING WENBIN, MINOMI KENJIROU
Year of Publication 30.07.2018
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Year of Publication 30.07.2018
Patent
GST-PI RNA RNA INTERFERENCE AGENTS FOR GST-PI GENE MODULATION
HARBORTH JENS, TAKAHASHI HIROKAZU, ZHANG JUN, AHMADIAN MOHAMMAD, TERADA ERIKA, YING WENBIN, MINOMI KENJIROU
Year of Publication 01.09.2017
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Year of Publication 01.09.2017
Patent