CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Almqvist, Helena, Axelsson, Hanna, Jafari, Rozbeh, Dan, Chen, Mateus, André, Haraldsson, Martin, Larsson, Andreas, Molina, Daniel Martinez, Artursson, Per, Lundbäck, Thomas, Nordlund, Pär
Published in Nature communications (24.03.2016)
Published in Nature communications (24.03.2016)
Get full text
Journal Article
Identification of novel small molecules that inhibit STAT3-dependent transcription and function
Kolosenko, Iryna, Yu, Yasmin, Busker, Sander, Dyczynski, Matheus, Liu, Jianping, Haraldsson, Martin, Palm Apergi, Caroline, Helleday, Thomas, Tamm, Katja Pokrovskaja, Page, Brent D G, Grander, Dan
Published in PloS one (21.06.2017)
Published in PloS one (21.06.2017)
Get full text
Journal Article
Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound
Giovannucci, Tatiana A., Salomons, Florian A., Haraldsson, Martin, Elfman, Lotta H. M., Wickström, Malin, Young, Patrick, Lundbäck, Thomas, Eirich, Jürgen, Altun, Mikael, Jafari, Rozbeh, Gustavsson, Anna-Lena, Johnsen, John Inge, Dantuma, Nico P.
Published in Cell death & disease (06.10.2021)
Published in Cell death & disease (06.10.2021)
Get full text
Journal Article
A drug screening assay on cancer cells chronically adapted to acidosis
Pellegrini, Paola, Serviss, Jason T, Lundbäck, Thomas, Bancaro, Nicolo, Mazurkiewicz, Magdalena, Kolosenko, Iryna, Yu, Di, Haraldsson, Martin, D'Arcy, Padraig, Linder, Stig, De Milito, Angelo
Published in Cancer cell international (25.09.2018)
Published in Cancer cell international (25.09.2018)
Get full text
Journal Article
Enhanced cytotoxicity of a novel family of ATPase inhibitors in colorectal cancer cells with high NAT2 activity
Zhang, Xiaonan, Akcan, Ece, Correia, Mario, Rameika, Natallia, Kundu, Snehangshu, Stoimenov, Ivaylo, Rendo, Veronica, Eriksson, Anna U., Haraldsson, Martin, Globisch, Daniel, Sjöblom, Tobias
Published in Biochemical pharmacology (01.09.2022)
Published in Biochemical pharmacology (01.09.2022)
Get full text
Journal Article
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Published in Nature communications (16.03.2018)
Published in Nature communications (16.03.2018)
Get full text
Journal Article
Discovery of a novel inhibitor of macropinocytosis with antiviral activity
Porebski, Bartlomiej, Christ, Wanda, Corman, Alba, Haraldsson, Martin, Barz, Myriam, Lidemalm, Louise, Häggblad, Maria, Ilmain, Juliana, Wright, Shane C., Murga, Matilde, Schlegel, Jan, Jarvius, Malin, Lapins, Maris, Sezgin, Erdinc, Bhabha, Gira, Lauschke, Volker M., Carreras-Puigvert, Jordi, Lafarga, Miguel, Klingström, Jonas, Hühn, Daniela, Fernandez-Capetillo, Oscar
Published in Molecular therapy (2024)
Published in Molecular therapy (2024)
Get full text
Journal Article
Structure-Guided Design of Novel Thiazolidine Inhibitors of O‑Acetyl Serine Sulfhydrylase from Mycobacterium tuberculosis
Poyraz, Ömer, Jeankumar, Variam Ullas, Saxena, Shalini, Schnell, Robert, Haraldsson, Martin, Yogeeswari, Perumal, Sriram, Dharmarajan, Schneider, Gunter
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
Get full text
Journal Article
High-affinity recognition of the human C-reactive protein independent of phosphocholineElectronic supplementary information (ESI) available: 1H and 13C NMR spectra, mass spectra (HRMS & ESI MS), MALDI-TOF MS for peptide conjugates, SPR sensorgrams from competition experiments. See DOI: 10.1039/c7ob00684e
Yang, Jie, Gustavsson, Anna-Lena, Haraldsson, Martin, Karlsson, Göran, Norberg, Thomas, Baltzer, Lars
Year of Publication 31.05.2017
Year of Publication 31.05.2017
Get full text
Journal Article
Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
Popova, Gergana, Ladds, Marcus J. G. W, Johansson, Lars, Saleh, Aljona, Larsson, Johanna, Sandberg, Lars, Sahlberg, Sara Häggblad, Qian, Weixing, Gullberg, Hjalmar, Garg, Neeraj, Gustavsson, Anna-Lena, Haraldsson, Martin, Lane, David, Yngve, Ulrika, Lain, Sonia
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
Get full text
Journal Article
Photo-physical characterization of high triplet yield brominated fluoresceins by transient state (TRAST) spectroscopy
Demirbay, Baris, Baryshnikov, Glib, Haraldsson, Martin, Piguet, Joachim, Ågren, Hans, Widengren, Jerker
Published in Methods and applications in fluorescence (01.10.2023)
Published in Methods and applications in fluorescence (01.10.2023)
Get full text
Journal Article
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Fernández, Andrés Pastor, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Published in Nature communications (18.08.2023)
Published in Nature communications (18.08.2023)
Get full text
Journal Article
Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy
Giovannucci, Tatiana A., Salomons, Florian A., Stoy, Henriette, Herzog, Laura K., Xu, Shanshan, Qian, Weixing, Merino, Lara G., Gierisch, Maria E., Haraldsson, Martin, Lystad, Alf H., Uvell, Hanna, Simonsen, Anne, Gustavsson, Anna-Lena, Vallin, Michaela, Dantuma, Nico P.
Published in Autophagy (03.07.2022)
Published in Autophagy (03.07.2022)
Get full text
Journal Article
Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase
Kleinschmidt, Thea K, Haraldsson, Martin, Basavarajappa, Devaraj, Lundeberg, Erik, Thulasingam, Madhuranayaki, Ekoff, Maria, Fauland, Alexander, Lehmann, Christoph, Kahnt, Astrid S, Lindbom, Lennart, Haeggström, Jesper Z
Published in The Journal of pharmacology and experimental therapeutics (01.10.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2015)
Get full text
Journal Article
Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C 4 Synthase
Kleinschmidt, Thea K., Haraldsson, Martin, Basavarajappa, Devaraj, Lundeberg, Erik, Thulasingam, Madhuranayaki, Ekoff, Maria, Fauland, Alexander, Lehmann, Christoph, Kahnt, Astrid S., Lindbom, Lennart, Haeggström, Jesper Z.
Published in The Journal of pharmacology and experimental therapeutics (01.10.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2015)
Get full text
Journal Article
Identification of inhibitors of Tartrate‐resistant acid phosphatase (TRAP/ACP5) activity by small‐molecule screening
Reithmeier, Anja, Lundbäck, Thomas, Haraldsson, Martin, Frank, Martin, Ek‐Rylander, Barbro, Nyholm, Per‐Georg, Gustavsson, Anna‐Lena, Andersson, Göran
Published in Chemical biology & drug design (01.07.2018)
Published in Chemical biology & drug design (01.07.2018)
Get full text
Journal Article
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
Zhang, Si Min, Paulin, Cynthia B.J., Shu, Huazhang, Yagüe-Capilla, Miriam, Michel, Maurice, Marttila, Petra, Ortis, Florian, Bwanika, Henri Colyn, Dirks, Christopher, Venkatram, Rajagopal Papagudi, Wiita, Elisée, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Hormann, Femke M., Koolmeister, Tobias, Linde, Erika, Lee, Sun, Llona-Minguez, Sabin, Haraldsson, Martin, Axelsson, Hanna, Strömberg, Kia, Homan, Evert J., Scobie, Martin, Lundbäck, Thomas, Helleday, Thomas, Rudd, Sean G.
Published in iScience (16.02.2024)
Published in iScience (16.02.2024)
Get full text
Journal Article