A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
Wakita, Masahiro, Takahashi, Akiko, Sano, Osamu, Loo, Tze Mun, Imai, Yoshinori, Narukawa, Megumi, Iwata, Hidehisa, Matsudaira, Tatsuyuki, Kawamoto, Shimpei, Ohtani, Naoko, Yoshimori, Tamotsu, Hara, Eiji
Published in Nature communications (22.04.2020)
Published in Nature communications (22.04.2020)
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Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion
Okumura, Shintaro, Konishi, Yusuke, Narukawa, Megumi, Sugiura, Yuki, Yoshimoto, Shin, Arai, Yuriko, Sato, Shintaro, Yoshida, Yasuo, Tsuji, Shunya, Uemura, Ken, Wakita, Masahiro, Matsudaira, Tatsuyuki, Matsumoto, Tomonori, Kawamoto, Shimpei, Takahashi, Akiko, Itatani, Yoshiro, Miki, Hiroaki, Takamatsu, Manabu, Obama, Kazutaka, Takeuchi, Kengo, Suematsu, Makoto, Ohtani, Naoko, Fukunaga, Yosuke, Ueno, Masashi, Sakai, Yoshiharu, Nagayama, Satoshi, Hara, Eiji
Published in Nature communications (28.09.2021)
Published in Nature communications (28.09.2021)
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Exosomes maintain cellular homeostasis by excreting harmful DNA from cells
Takahashi, Akiko, Okada, Ryo, Nagao, Koji, Kawamata, Yuka, Hanyu, Aki, Yoshimoto, Shin, Takasugi, Masaki, Watanabe, Sugiko, Kanemaki, Masato T, Obuse, Chikashi, Hara, Eiji
Published in Nature communications (16.05.2017)
Published in Nature communications (16.05.2017)
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Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Yoshimoto, Shin, Loo, Tze Mun, Atarashi, Koji, Kanda, Hiroaki, Sato, Seidai, Oyadomari, Seiichi, Iwakura, Yoichiro, Oshima, Kenshiro, Morita, Hidetoshi, Hattori, Masahira, Honda, Kenya, Ishikawa, Yuichi, Hara, Eiji, Ohtani, Naoko
Published in Nature (London) (04.07.2013)
Published in Nature (London) (04.07.2013)
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Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
Takahashi, Akiko, Loo, Tze Mun, Okada, Ryo, Kamachi, Fumitaka, Watanabe, Yoshihiro, Wakita, Masahiro, Watanabe, Sugiko, Kawamoto, Shimpei, Miyata, Kenichi, Barber, Glen N., Ohtani, Naoko, Hara, Eiji
Published in Nature communications (28.03.2018)
Published in Nature communications (28.03.2018)
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Obesity and Cancer: A Gut Microbial Connection
OHTANI, Naoko, YOSHIMOTO, Shin, HARA, Eiji
Published in Cancer research (Chicago, Ill.) (01.04.2014)
Published in Cancer research (Chicago, Ill.) (01.04.2014)
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Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity
Loo, Tze Mun, Kamachi, Fumitaka, Watanabe, Yoshihiro, Yoshimoto, Shin, Kanda, Hiroaki, Arai, Yuriko, Nakajima-Takagi, Yaeko, Iwama, Atsushi, Koga, Tomoaki, Sugimoto, Yukihiko, Ozawa, Takayuki, Nakamura, Masaru, Kumagai, Miho, Watashi, Koichi, Taketo, Makoto M., Aoki, Tomohiro, Narumiya, Shuh, Oshima, Masanobu, Arita, Makoto, Hara, Eiji, Ohtani, Naoko
Published in Cancer discovery (01.05.2017)
Published in Cancer discovery (01.05.2017)
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The 6th international cell senescence association conference
Kawamoto, Shimpei, Matsumoto, Tomonori, Takasugi, Masaki, Hara, Eiji
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.08.2022)
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.08.2022)
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Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16Ink4a through aberrant PRC1-mediated histone modification
Uni, Masahiro, Masamoto, Yosuke, Sato, Tomohiko, Kamikubo, Yasuhiko, Arai, Shunya, Hara, Eiji, Kurokawa, Mineo
Published in Leukemia (01.01.2019)
Published in Leukemia (01.01.2019)
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Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction
Johmura, Yoshikazu, Shimada, Midori, Misaki, Toshinori, Naiki-Ito, Aya, Miyoshi, Hiroyuki, Motoyama, Noboru, Ohtani, Naoko, Hara, Eiji, Nakamura, Motoki, Morita, Akimichi, Takahashi, Satoru, Nakanishi, Makoto
Published in Molecular cell (03.07.2014)
Published in Molecular cell (03.07.2014)
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Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer
Miyata, Kenichi, Imai, Yoshinori, Satoshi Hori, Mika Nishio, Loo, Tze Mun, Okada, Ryo, Yang, Liying, Nakadai, Tomoyoshi, Maruyama, Reo, Fujii, Risa, Ueda, Koji, Jiang, Li, Zheng, Hao, Toyokuni, Shinya, Sakata, Toyonori, Shirahige, Katsuhiko, Kojima, Ryosuke, Nakayama, Mizuho, Oshima, Masanobu, Nagayama, Satoshi, Seimiya, Hiroyuki, Hirota, Toru, Saya, Hideyuki, Hara, Eiji, Takahashi, Akiko
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2021)
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Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota
Kawamoto, Shimpei, Uemura, Ken, Hori, Nozomi, Takayasu, Lena, Konishi, Yusuke, Katoh, Kazutaka, Matsumoto, Tomonori, Suzuki, Masae, Sakai, Yusuke, Matsudaira, Tatsuyuki, Adachi, Takahiro, Ohtani, Naoko, Standley, Daron M., Suda, Wataru, Fukuda, Shinji, Hara, Eiji
Published in Nature cell biology (01.06.2023)
Published in Nature cell biology (01.06.2023)
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p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
Okuma, Atsushi, Hanyu, Aki, Watanabe, Sugiko, Hara, Eiji
Published in Nature communications (12.12.2017)
Published in Nature communications (12.12.2017)
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