Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease
Grealish, Shane, Diguet, Elsa, Kirkeby, Agnete, Mattsson, Bengt, Heuer, Andreas, Bramoulle, Yann, Van Camp, Nadja, Perrier, Anselme L., Hantraye, Philippe, Björklund, Anders, Parmar, Malin
Published in Cell stem cell (06.11.2014)
Published in Cell stem cell (06.11.2014)
Get full text
Journal Article
Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease
Le Douce, Juliette, Maugard, Marianne, Veran, Julien, Matos, Marco, Jégo, Pierrick, Vigneron, Pierre-Antoine, Faivre, Emilie, Toussay, Xavier, Vandenberghe, Michel, Balbastre, Yaël, Piquet, Juliette, Guiot, Elvire, Tran, Nguyet Thuy, Taverna, Myriam, Marinesco, Stéphane, Koyanagi, Ayumi, Furuya, Shigeki, Gaudin-Guérif, Mylène, Goutal, Sébastien, Ghettas, Aurélie, Pruvost, Alain, Bemelmans, Alexis-Pierre, Gaillard, Marie-Claude, Cambon, Karine, Stimmer, Lev, Sazdovitch, Véronique, Duyckaerts, Charles, Knott, Graham, Hérard, Anne-Sophie, Delzescaux, Thierry, Hantraye, Philippe, Brouillet, Emmanuel, Cauli, Bruno, Oliet, Stéphane H.R., Panatier, Aude, Bonvento, Gilles
Published in Cell metabolism (03.03.2020)
Published in Cell metabolism (03.03.2020)
Get full text
Journal Article
Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate
Goulay, Romain, Flament, Julien, Gauberti, Maxime, Naveau, Michael, Pasquet, Nolwenn, Gakuba, Clement, Emery, Evelyne, Hantraye, Philippe, Vivien, Denis, Aron-Badin, Romina, Gaberel, Thomas
Published in Stroke (1970) (01.08.2017)
Published in Stroke (1970) (01.08.2017)
Get full text
Journal Article
Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging
Lavisse, Sonia, Guillermier, Martine, Hérard, Anne-Sophie, Petit, Fanny, Delahaye, Marion, Van Camp, Nadja, Ben Haim, Lucile, Lebon, Vincent, Remy, Philippe, Dollé, Frédéric, Delzescaux, Thierry, Bonvento, Gilles, Hantraye, Philippe, Escartin, Carole
Published in The Journal of neuroscience (08.08.2012)
Published in The Journal of neuroscience (08.08.2012)
Get full text
Journal Article
MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates
Aron Badin, Romina, Bugi, Aurore, Williams, Susannah, Vadori, Marta, Michael, Marie, Jan, Caroline, Nassi, Alberto, Lecourtois, Sophie, Blancher, Antoine, Cozzi, Emanuele, Hantraye, Philippe, Perrier, Anselme L
Published in Nature communications (25.09.2019)
Published in Nature communications (25.09.2019)
Get full text
Journal Article
Ectosomes: a new mechanism for non-exosomal secretion of tau protein
Dujardin, Simon, Bégard, Séverine, Caillierez, Raphaëlle, Lachaud, Cédrick, Delattre, Lucie, Carrier, Sébastien, Loyens, Anne, Galas, Marie-Christine, Bousset, Luc, Melki, Ronald, Aurégan, Gwennaëlle, Hantraye, Philippe, Brouillet, Emmanuel, Buée, Luc, Colin, Morvane
Published in PloS one (27.06.2014)
Published in PloS one (27.06.2014)
Get full text
Journal Article
The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases
Ben Haim, Lucile, Ceyzériat, Kelly, Carrillo-de Sauvage, Maria Angeles, Aubry, Fabien, Auregan, Gwennaëlle, Guillermier, Martine, Ruiz, Marta, Petit, Fanny, Houitte, Diane, Faivre, Emilie, Vandesquille, Matthias, Aron-Badin, Romina, Dhenain, Marc, Déglon, Nicole, Hantraye, Philippe, Brouillet, Emmanuel, Bonvento, Gilles, Escartin, Carole
Published in The Journal of neuroscience (11.02.2015)
Published in The Journal of neuroscience (11.02.2015)
Get full text
Journal Article
Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates
Gauvain, Gregory, Akolkar, Himanshu, Chaffiol, Antoine, Arcizet, Fabrice, Khoei, Mina A, Desrosiers, Mélissa, Jaillard, Céline, Caplette, Romain, Marre, Olivier, Bertin, Stéphane, Fovet, Claire-Maelle, Demilly, Joanna, Forster, Valérie, Brazhnikova, Elena, Hantraye, Philippe, Pouget, Pierre, Douar, Anne, Pruneau, Didier, Chavas, Joël, Sahel, José-Alain, Dalkara, Deniz, Duebel, Jens, Benosman, Ryad, Picaud, Serge
Published in Communications biology (27.01.2021)
Published in Communications biology (27.01.2021)
Get full text
Journal Article
Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates
Fayard, Audrey, Fenyi, Alexis, Lavisse, Sonia, Dovero, Sandra, Bousset, Luc, Bellande, Tracy, Lecourtois, Sophie, Jouy, Christophe, Guillermier, Martine, Jan, Caroline, Gipchtein, Pauline, Dehay, Benjamin, Bezard, Erwan, Melki, Ronald, Hantraye, Philippe, Aron Badin, Romina
Published in Neurobiology of disease (01.05.2023)
Published in Neurobiology of disease (01.05.2023)
Get full text
Journal Article
Comparative test-retest variability of outcome parameters derived from brain [18F]FDG PET studies in non-human primates
Goutal, Sébastien, Tournier, Nicolas, Guillermier, Martine, Van Camp, Nadja, Barret, Olivier, Gaudin, Mylène, Bottlaender, Michel, Hantraye, Philippe, Lavisse, Sonia
Published in PloS one (05.10.2020)
Published in PloS one (05.10.2020)
Get full text
Journal Article
THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency
Vautheny, Audrey, Duwat, Charlotte, Aurégan, Gwennaëlle, Joséphine, Charlène, Hérard, Anne-Sophie, Jan, Caroline, Mitja, Julien, Gipchtein, Pauline, Gaillard, Marie-Claude, Buée, Luc, Blum, David, Hantraye, Philippe, Bonvento, Gilles, Brouillet, Emmanuel, Cambon, Karine, Bemelmans, Alexis-Pierre
Published in Neurobiology of disease (01.07.2021)
Published in Neurobiology of disease (01.07.2021)
Get full text
Journal Article
A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin
Damiano, Maria, Diguet, Elsa, Malgorn, Carole, D'Aurelio, Marilena, Galvan, Laurie, Petit, Fanny, Benhaim, Lucile, Guillermier, Martine, Houitte, Diane, Dufour, Noelle, Hantraye, Philippe, Canals, Josep M, Alberch, Jordi, Delzescaux, Thierry, Déglon, Nicole, Beal, M Flint, Brouillet, Emmanuel
Published in Human molecular genetics (01.10.2013)
Published in Human molecular genetics (01.10.2013)
Get full text
Journal Article
In vivo evidence for the selective subcortical degeneration in Huntington's disease
Douaud, Gwenaëlle, Behrens, Timothy E., Poupon, Cyril, Cointepas, Yann, Jbabdi, Saâd, Gaura, Véronique, Golestani, Narly, Krystkowiak, Pierre, Verny, Christophe, Damier, Philippe, Bachoud-Lévi, Anne-Catherine, Hantraye, Philippe, Remy, Philippe
Published in NeuroImage (Orlando, Fla.) (15.07.2009)
Published in NeuroImage (Orlando, Fla.) (15.07.2009)
Get full text
Journal Article
Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology
Duwat, Charlotte, Léal, Pauline, Vautheny, Audrey, Aurégan, Gwennaëlle, Joséphine, Charlène, Gaillard, Marie-Claude, Hérard, Anne-Sophie, Jan, Caroline, Gipchtein, Pauline, Mitja, Julien, Fouquet, Stéphane, Niepon, Marie-Laure, Hantraye, Philippe, Brouillet, Emmanuel, Bonvento, Gilles, Cambon, Karine, Bemelmans, Alexis-Pierre
Published in Neurobiology of disease (01.06.2023)
Published in Neurobiology of disease (01.06.2023)
Get full text
Journal Article
Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat
d'Orange, Marie, Aurégan, Gwénaelle, Cheramy, Dimitri, Gaudin-Guérif, Mylène, Lieger, Sarah, Guillermier, Martine, Stimmer, Lev, Joséphine, Charlène, Hérard, Anne-Sophie, Gaillard, Marie-Claude, Petit, Fanny, Kiessling, Maren Christine, Schmitz, Christoph, Colin, Morvane, Buée, Luc, Panayi, Fany, Diguet, Elsa, Brouillet, Emmanuel, Hantraye, Philippe, Bemelmans, Alexis-Pierre, Cambon, Karine
Published in Brain (London, England : 1878) (01.02.2018)
Published in Brain (London, England : 1878) (01.02.2018)
Get full text
Journal Article
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies
Dujardin, Simon, Lécolle, Katia, Caillierez, Raphaëlle, Bégard, Séverine, Zommer, Nadège, Lachaud, Cédrick, Carrier, Sébastien, Dufour, Noëlle, Aurégan, Gwennaëlle, Winderickx, Joris, Hantraye, Philippe, Déglon, Nicole, Colin, Morvane, Buée, Luc
Published in Acta neuropathologica communications (30.01.2014)
Published in Acta neuropathologica communications (30.01.2014)
Get full text
Journal Article
Long-Term Follow-Up of a Phase I/II Study of ProSavin, a Lentiviral Vector Gene Therapy for Parkinson's Disease
Palfi, Stéphane, Gurruchaga, Jean Marc, Lepetit, Hélène, Howard, Katy, Ralph, G Scott, Mason, Sarah, Gouello, Gaëtane, Domenech, Philippe, Buttery, Philip C, Hantraye, Philippe, Tuckwell, Nicola J, Barker, Roger A, Mitrophanous, Kyriacos A
Published in Human gene therapy. Clinical development (01.09.2018)
Published in Human gene therapy. Clinical development (01.09.2018)
Get more information
Journal Article
In vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin
Kraska, Audrey, Santin, Mathieu D, Dorieux, Olène, Joseph-Mathurin, Nelly, Bourrin, Emmanuel, Petit, Fanny, Jan, Caroline, Chaigneau, Marion, Hantraye, Philippe, Lestage, Pierre, Dhenain, Marc
Published in PloS one (25.09.2012)
Published in PloS one (25.09.2012)
Get full text
Journal Article
Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque
Comoy, Emmanuel E, Mikol, Jacqueline, Jaffré, Nina, Lebon, Vincent, Levavasseur, Etienne, Streichenberger, Nathalie, Sumian, Chryslain, Perret-Liaudet, Armand, Eloit, Marc, Andreoletti, Olivier, Haïk, Stéphane, Hantraye, Philippe, Deslys, Jean-Philippe
Published in Nature communications (02.11.2017)
Published in Nature communications (02.11.2017)
Get full text
Journal Article
The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo
Cresto, Noémie, Gaillard, Marie-Claude, Gardier, Camille, Gubinelli, Francesco, Diguet, Elsa, Bellet, Déborah, Legroux, Laurine, Mitja, Julien, Auregan, Gwenaëlle, Guillermier, Martine, Josephine, Charlène, Jan, Caroline, Dufour, Noëlle, Joliot, Alain, Hantraye, Philippe, Bonvento, Gilles, Déglon, Nicole, Bemelmans, Alexis-Pierre, Cambon, Karine, Liot, Géraldine, Brouillet, Emmanuel
Published in Neurobiology of disease (01.02.2020)
Published in Neurobiology of disease (01.02.2020)
Get full text
Journal Article