BACE1 inhibitors: A head group scan on a series of amides
Woltering, Thomas J., Wostl, Wolfgang, Hilpert, Hans, Rogers-Evans, Mark, Pinard, Emmanuel, Mayweg, Alexander, Göbel, Martin, Banner, David W., Benz, Jörg, Travagli, Massimiliano, Pollastrini, Martina, Marconi, Guido, Gabellieri, Emanuele, Guba, Wolfgang, Mauser, Harald, Andreini, Matteo, Jacobsen, Helmut, Power, Eoin, Narquizian, Robert
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Get full text
Journal Article
Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE―/― mice
BOT, Ilze, BOT, Martine, BIESSEN, Erik A. L, VAN HEININGEN, Sandra H, VAN SANTBRINK, Peter J, LANKHUIZEN, Inge M, HARTMAN, Peter, GRUENER, Sabine, HILPERT, Hans, VAN BERKEL, Theo J. C, FINGERLE, Jürgen
Published in Cardiovascular research (01.01.2011)
Published in Cardiovascular research (01.01.2011)
Get full text
Journal Article
Efficient Synthesis of Novel NK1 Receptor Antagonists: Selective 1,4-Addition of Grignard Reagents to 6-Chloronicotinic Acid Derivatives
Hoffmann-Emery, Fabienne, Hilpert, Hans, Scalone, Michelangelo, Waldmeier, Pius
Published in Journal of organic chemistry (03.03.2006)
Published in Journal of organic chemistry (03.03.2006)
Get full text
Journal Article
Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice
Jacobsen, Helmut, Ozmen, Laurence, Caruso, Antonello, Narquizian, Robert, Hilpert, Hans, Jacobsen, Bjoern, Terwel, Dick, Tanghe, An, Bohrmann, Bernd
Published in The Journal of neuroscience (27.08.2014)
Published in The Journal of neuroscience (27.08.2014)
Get full text
Journal Article
β‑Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease
Hilpert, Hans, Guba, Wolfgang, Woltering, Thomas J, Wostl, Wolfgang, Pinard, Emmanuel, Mauser, Harald, Mayweg, Alexander V, Rogers-Evans, Mark, Humm, Roland, Krummenacher, Daniela, Muser, Thorsten, Schnider, Christian, Jacobsen, Helmut, Ozmen, Laurence, Bergadano, Alessandra, Banner, David W, Hochstrasser, Remo, Kuglstatter, Andreas, David-Pierson, Pascale, Fischer, Holger, Polara, Alessandra, Narquizian, Robert
Published in Journal of medicinal chemistry (23.05.2013)
Published in Journal of medicinal chemistry (23.05.2013)
Get full text
Journal Article
Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function
Oliverio, Matteo, Schmidt, Elena, Mauer, Jan, Baitzel, Catherina, Hansmeier, Nils, Khani, Sajjad, Konieczka, Sandra, Pradas-Juni, Marta, Brodesser, Susanne, Van, Trieu-My, Bartsch, Deniz, Brönneke, Hella S., Heine, Markus, Hilpert, Hans, Tarcitano, Emilio, Garinis, George A., Frommolt, Peter, Heeren, Joerg, Mori, Marcelo A., Brüning, Jens C., Kornfeld, Jan-Wilhelm
Published in Nature cell biology (01.03.2016)
Published in Nature cell biology (01.03.2016)
Get full text
Journal Article
Bace2 Is a β Cell-Enriched Protease that Regulates Pancreatic β Cell Function and Mass
Esterházy, Daria, Stützer, Ina, Wang, Haiyan, Rechsteiner, Markus P., Beauchamp, Jeremy, Döbeli, Heinz, Hilpert, Hans, Matile, Hugues, Prummer, Michael, Schmidt, Alexander, Lieske, Nora, Boehm, Bernhard, Marselli, Lorella, Bosco, Domenico, Kerr-Conte, Julie, Aebersold, Ruedi, Spinas, Giatgen Andreia, Moch, Holger, Migliorini, Cristiano, Stoffel, Markus
Published in Cell metabolism (07.09.2011)
Published in Cell metabolism (07.09.2011)
Get full text
Journal Article
Synthesis of the HIV-Proteinase Inhibitor Saquinavir: A Challenge for Process Research
Wolfgang Göbring, Surendra Gokbale, Hans Hilpert, Felix Roessler, Markus Schlageter, Peter Vogt
Published in Chimia (27.11.1996)
Published in Chimia (27.11.1996)
Get full text
Journal Article
Identification of Potent and Selective Cathepsin S Inhibitors Containing Different Central Cyclic Scaffolds
Hilpert, Hans, Mauser, Harald, Humm, Roland, Anselm, Lilli, Kuehne, Holger, Hartmann, Guido, Gruener, Sabine, Banner, David W, Benz, Joerg, Gsell, Bernard, Kuglstatter, Andreas, Stihle, Martine, Thoma, Ralf, Sanchez, Rubén Alvarez, Iding, Hans, Wirz, Beat, Haap, Wolfgang
Published in Journal of medicinal chemistry (12.12.2013)
Published in Journal of medicinal chemistry (12.12.2013)
Get full text
Journal Article
Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes
Bénardeau, Agnes, Benz, Jörg, Binggeli, Alfred, Blum, Denise, Boehringer, Markus, Grether, Uwe, Hilpert, Hans, Kuhn, Bernd, Märki, Hans Peter, Meyer, Markus, Püntener, Kurt, Raab, Susanne, Ruf, Armin, Schlatter, Daniel, Mohr, Peter
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Get full text
Journal Article
Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APP London Mice
Jacobsen, Helmut, Ozmen, Laurence, Caruso, Antonello, Narquizian, Robert, Hilpert, Hans, Jacobsen, Bjoern, Terwel, Dick, Tanghe, An, Bohrmann, Bernd
Published in The Journal of neuroscience (27.08.2014)
Published in The Journal of neuroscience (27.08.2014)
Get full text
Journal Article
Combined Treatment with a BACE Inhibitor and Anti-A beta Antibody Gantenerumab Enhances Amyloid Reduction in APP sub(London) Mice
Jacobsen, Helmut, Ozmen, Laurence, Caruso, Antonello, Narquizian, Robert, Hilpert, Hans, Jacobsen, Bjoern, Terwel, Dick, Tanghe, An, Bohrmann, Bernd
Published in The Journal of neuroscience (27.08.2014)
Published in The Journal of neuroscience (27.08.2014)
Get full text
Journal Article
Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones
Banner, David W., Gsell, Bernard, Benz, Jörg, Bertschinger, Julian, Burger, Dominique, Brack, Simon, Cuppuleri, Simon, Debulpaep, Maja, Gast, Alain, Grabulovski, Dragan, Hennig, Michael, Hilpert, Hans, Huber, Walter, Kuglstatter, Andreas, Kusznir, Eric, Laeremans, Toon, Matile, Hugues, Miscenic, Christian, Rufer, Arne C., Schlatter, Daniel, Steyaert, Jan, Stihle, Martine, Thoma, Ralf, Weber, Martin, Ruf, Armin
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2013)
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2013)
Get full text
Journal Article
Structure-based design of indole propionic acids as novel PPARα/γ co-agonists
Kuhn, Bernd, Hilpert, Hans, Benz, Jörg, Binggeli, Alfred, Grether, Uwe, Humm, Roland, Märki, Hans Peter, Meyer, Markus, Mohr, Peter
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Get full text
Journal Article
Discovery of a factor Xa inhibitor (3 R,4 R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate
Anselm, Lilli, Banner, David W., Benz, Jörg, Groebke Zbinden, Katrin, Himber, Jacques, Hilpert, Hans, Huber, Walter, Kuhn, Bernd, Mary, Jean-Luc, Otteneder, Michael B., Panday, Narendra, Ricklin, Fabienne, Stahl, Martin, Thomi, Stefan, Haap, Wolfgang
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Get full text
Journal Article
Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists
Grether, Uwe, Bénardeau, Agnes, Benz, Jörg, Binggeli, Alfred, Blum, Denise, Hilpert, Hans, Kuhn, Bernd, Märki, Hans Peter, Meyer, Markus, Mohr, Peter, Püntener, Kurt, Raab, Susanne, Ruf, Armin, Schlatter, Daniel
Published in ChemMedChem (08.06.2009)
Published in ChemMedChem (08.06.2009)
Get full text
Journal Article