Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate
Castro, Joel, Harrington, Andrea M, Hughes, Patrick A, Martin, Christopher M, Ge, Pei, Shea, Courtney M, Jin, Hong, Jacobson, Sarah, Hannig, Gerhard, Mann, Elizabeth, Cohen, Mitchell B, MacDougall, James E, Lavins, Bernard J, Kurtz, Caroline B, Silos-Santiago, Inmaculada, Johnston, Jeffrey M, Currie, Mark G, Blackshaw, L. Ashley, Brierley, Stuart M
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2013)
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Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
Busby, Robert W., Bryant, Alexander P., Bartolini, Wilmin P., Cordero, Etchell A., Hannig, Gerhard, Kessler, Marco M., Mahajan-Miklos, Shalina, Pierce, Christine M., Solinga, Robert M., Sun, Li Jing, Tobin, Jenny V., Kurtz, Caroline B., Currie, Mark G.
Published in European journal of pharmacology (15.12.2010)
Published in European journal of pharmacology (15.12.2010)
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Experimentally Induced Bladder Permeability Evokes Bladder Afferent Hypersensitivity in the Absence of Inflammation
Grundy, Luke, Caldwell, Ashlee, Lumsden, Amanda, Mohammadi, Ehsan, Hannig, Gerhard, Greenwood Van-Meervald, Beverley, Brierley, Stuart M.
Published in Frontiers in neuroscience (23.10.2020)
Published in Frontiers in neuroscience (23.10.2020)
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Linaclotide activates guanylate cyclase‐C/cGMP/protein kinase‐II‐dependent trafficking of CFTR in the intestine
Ahsan, Md. Kaimul, Tchernychev, Boris, Kessler, Marco M., Solinga, Robert M., Arthur, David, Linde, Cristina I., Silos‐Santiago, Inmaculada, Hannig, Gerhard, Ameen, Nadia A.
Published in Physiological reports (01.06.2017)
Published in Physiological reports (01.06.2017)
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A Methionine Aminopeptidase-2 Inhibitor, PPI-2458, for the Treatment of Rheumatoid Arthritis
Bernier, Sylvie G., Lazarus, Douglas D., Clark, Edward, Doyle, Beth, Labenski, Matthew T., Thompson, Charles D., Westlin, William F., Hannig, Gerhard, Erikson, R. L.
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.2004)
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Guanylate cyclase 2C agonism corrects CFTR mutants
Arora, Kavisha, Huang, Yunjie, Mun, Kyushik, Yarlagadda, Sunitha, Sundaram, Nambirajan, Kessler, Marco M, Hannig, Gerhard, Kurtz, Caroline B, Silos-Santiago, Inmaculada, Helmrath, Michael, Palermo, Joseph J, Clancy, John P, Steinbrecher, Kris A, Naren, Anjaparavanda P
Published in JCI insight (05.10.2017)
Published in JCI insight (05.10.2017)
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EP1238: COLORECTAL NOCICEPTIVE PROCESSING IN THE CAUDAL VENTROLATERAL MEDULLA AND THE LATERAL PARABRACHIAL NUCLEI IS INCREASED IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY AND IS REVERSED BY CHRONIC LINACLOTIDE TREATMENT
Harrington, Andrea, Wang, Qingqing, Hannig, Gerhard, Brierley, Stuart
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
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A Novel Methionine Aminopeptidase-2 Inhibitor, PPI-2458, Inhibits Non–Hodgkin's Lymphoma Cell Proliferation In vitro and In vivo
Cooper, Andrew C, Karp, Russell M, Clark, Edward J, Taghizadeh, Nazbeh R, Hoyt, Jennifer G, Labenski, Matthew T, Murray, Michael J, Hannig, Gerhard, Westlin, William F, Thompson, Charles D
Published in Clinical cancer research (15.04.2006)
Published in Clinical cancer research (15.04.2006)
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Su136 COLORECTAL NOCICEPTIVE PROCESSING IN THE ROSTRAL VENTROMEDIAL AND CAUDAL VENTROLATERAL MEDULLA IS INCREASED IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY AND IS REVERSED BY CHRONIC LINACLOTIDE TREATMENT
Harrington, Andrea, Wang, Qingqing, Hannig, Gerhard, Brierley, Stuart
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2021)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2021)
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Su134 INTRACOLONIC ADMINISTRATION OF LINACLOTIDE RELIEVES VISCERAL HYPERSENSITIVITY BY INHIBITING CHRONIC PSYCHOLOGICAL STRESS-INDUCED ACTIVATION OF CENTRAL NOCICEPTIVE PATHWAYS IN RATS
Ligon, Casey O., Hannig, Gerhard, Meerveld, Beverley Greenwood-Van
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2021)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2021)
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EP1239: DESCENDING PAIN MODULATION OF COLORECTAL NOCICEPTIVE PROCESSING IN THE SPINAL CORD IS IMBALANCED IN A MOUSE MODEL OF POST-COLITIS CHRONIC VISCERAL HYPERSENSITIVITY AND IS REDUCED BY CHRONIC ORAL LINACLOTIDE TREATMENT
Harrington, Andrea, Schober, Gudrun, Maddern, Jessica, Wang, Qingqing, Hannig, Gerhard, Brierley, Stuart
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
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240: COLON-TARGETED DELIVERY OF GUANYLATE CYCLASE-C AGONIST IW-3300 RELIEVES COMORBID CHRONIC PELVIC AND SOMATIC PAIN IN A RAT MODEL OF EARLY LIFE STRESS-INDUCED COLONIC HYPERSENSITIVITY
Ligon, Casey O., Ge, Pei, Hannig, Gerhard, Higgins, Carolyn S., Meerveld, Beverley Greenwood-Van
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
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1017 - Guanylate Cyclase 2C Activation Rescues the Folding Defect in F508Del CFTR
Arora, Kavisha, Kessler, Marco, Hannig, Gerhard, Naren, Anjaparavanda P.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2018)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2018)
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Linaclotide treatment reduces endometriosis-associated vaginal hyperalgesia and mechanical allodynia through viscerovisceral cross-talk
Ge, Pei, Ren, Jingmei, Harrington, Andrea M, Grundy, Luke, Castro, Joel, Brierley, Stuart M, Hannig, Gerhard
Published in Pain (Amsterdam) (01.11.2019)
Published in Pain (Amsterdam) (01.11.2019)
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Mo1146 CHRONIC INTRA-COLONIC LINACLOTIDE ADMINISTRATION ALTERS GLIAL ACTIVATION IN A MOUSE MODEL OF CHRONIC VISCERAL HYPERSENSITIVITY
Harrington, Andrea, Garcia-Caraballo, Sonia, Grundy, Luke, Castro, Joel, Hannig, Gerhard, Brierley, Stuart
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2020)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2020)
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Sa1677 – Chronic Colonic Administration of the Guanylate Cyclase-C Agonist Linaclotide Attenuates Colitis Induced Bladder Afferent Hyperactivity
Grundy, Luke, Castro, Joel, Maddern, Jessica, Harrington, Andrea, Hannig, Gerhard, Ge, Pei, Brierley, Stuart
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2019)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2019)
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Sa1681 – Gc-C Agonism with Linaclotide Attenuates Chronic Stressinduced Colonic Hypersensitivity Independently of Elevated Crf Expression in the Central Nucleus of the Amygdala
Ligon, Casey O., Hannig, Gerhard, Ge, Pei, Higgins, Carolyn S., Meerveld, Beverley Greenwood-Van
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2019)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2019)
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Peripheral Guanylate Cyclase‐C modulation of corticolimbic activation and corticotropin‐releasing factor signaling in a rat model of stress‐induced colonic hypersensitivity
Ligon, Casey O., Hannig, Gerhard, Greenwood‐Van Meerveld, Beverley
Published in Neurogastroenterology and motility (01.03.2021)
Published in Neurogastroenterology and motility (01.03.2021)
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