Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors
Hanan, Emily J., Fucini, Raymond V., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Purkey, Hans E., VanderPorten, Erica C., Yang, Wenjin
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
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2-Aminobenzimidazoles as potent Aurora kinase inhibitors
Zhong, Min, Bui, Minna, Shen, Wang, Baskaran, Subramanian, Allen, Darin A., Elling, Robert A., Flanagan, W. Michael, Fung, Amy D., Hanan, Emily J., Harris, Shannon O., Heumann, Stacey A., Hoch, Ute, Ivy, Sheryl N., Jacobs, Jeffrey W., Lam, Stuart, Lee, Heman, McDowell, Robert S., Oslob, Johan D., Purkey, Hans E., Romanowski, Michael J., Silverman, Jeffrey A., Tangonan, Bradley T., Taverna, Pietro, Yang, Wenjin, Yoburn, Josh C., Yu, Chul H., Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Structure–activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists
Zhong, Min, Hanan, Emily J., Shen, Wang, Bui, Minna, Arkin, Michelle R., Barr, Kenneth J., Evanchik, Marc J., Hoch, Ute, Hyde, Jennifer, Martell, Jose R., Oslob, Johan D., Paulvannan, Kumar, Prabhu, Saileta, Silverman, Jeffrey A., Wright, Jasmin, Yu, Chul H., Zhu, Jiang, Flanagan, W. Mike
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors
Fucini, Raymond V., Hanan, Emily J., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Barr, Kenneth J., Zhu, Jiang, Yoburn, Joshua C., Liu, Yang, Fahr, Bruce T., Fan, Junfa, Lu, Yafan, Pham, Phuongly, Choong, Ingrid C., VanderPorten, Erica C., Bui, Minna, Purkey, Hans E., Evanchik, Marc J., Yang, Wenjin
Published in Bioorganic & medicinal chemistry (15.10.2008)
Published in Bioorganic & medicinal chemistry (15.10.2008)
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Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists
Zhong, Min, Shen, Wang, Barr, Kenneth J., Arbitrario, Jennifer P., Arkin, Michelle R., Bui, Minna, Chen, Teresa, Cunningham, Brian C., Evanchik, Marc J., Hanan, Emily J., Hoch, Ute, Huen, Karen, Hyde, Jennifer, Kumer, Jeffery L., Lac, Teresa, Lawrence, Chris E., Martell, Jose R., Oslob, Johan D., Paulvannan, Kumar, Prabhu, Saileta, Silverman, Jeffrey A., Wright, Jasmin, Yu, Chul H., Zhu, Jiang, Flanagan, W. Mike
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme
Elling, Robert A., Fucini, Raymond V., Hanan, Emily J., Barr, Kenneth J., Zhu, Jiang, Paulvannan, Kumar, Yang, Wenjin, Romanowski, Michael J.
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.08.2008)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.08.2008)
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Deletion of a previously uncharacterized lipoprotein lirL confers resistance to an inhibitor of type II signal peptidase in Acinetobacter baumannii
Huang, Ke-Jung, Pantua, Homer, Diao, Jingyu, Skippington, Elizabeth, Volny, Michael, Sandoval, Wendy, Tiku, Varnesh, Peng, Yutian, Sagolla, Meredith, Yan, Donghong, Kang, Jing, Katakam, Anand Kumar, Michaelian, Nairie, Reichelt, Mike, Tan, Man-Wah, Austin, Cary D., Xu, Min, Hanan, Emily, Kapadia, Sharookh B.
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2022)
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Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis
Zhou, Yuebiao, Aliagas, Ignacio, Wang, Shumei, Li, Chun Sing, Liu, Zhiguo, Bowman, Christine M., Burdick, Daniel J., Clark, Kevin R., Dening, Tahnee J., Flygare, John, Ganti, Anjani, Girgis, Hany S., Hanan, Emily J., Harris, Seth F., Hu, Chloe, Kapadia, Sharookh B., Koehler, Michael F.T., Lai, Tommy, Liang, Jun, Liu, Xingrong, Ma, Fang, Mao, Jialin, Nicolai, Jeremy, Sims, Jessica, Unhayaker, Savita, Wai, John, Wang, Xiaojing, Wu, Ping, Xu, Yiming, Yen, Chun-Wan, Zhang, Renwei, Elfert, Torben F., Tan, Man-Wah, Kofoed, Eric M., Crawford, Terry D.
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
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Abstract PR03: Selective degradation of mutant PIK3CA promotes increased mutant specificity in a subset of PI3K ATP-competitive inhibitors
Nguyen, Lan, Edgar, Kyle, Song, Kyung, Schmidt, Stephen, Schutz, Victorai, Ishisoko, Noriko, Torres, Eric, Das, Akash, Murali, Divya, Sideris, Steve, Wendorff, Timothy, Saabye, Matt, Purkey, Hans, Sudhamsu, Jawahar, Staben, Steven, Hanan, Emily, Hatzivassiliou, Georgia, Friedman, Lori, Endres, Nicholas F.
Published in Molecular cancer research (01.10.2020)
Published in Molecular cancer research (01.10.2020)
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Abstract 156: Preclinical characterization of GDC-0077, a specific PI3K alpha inhibitor in early clinical development
Edgar, Kyle, Hanan, Emily, Staben, Steven, Schmidt, Stephen, Hong, Rebecca, Song, Kyung, Young, Amy, Hamilton, Patricia, Arrazate, Alfonso, Cruz, Cecile de la, Belvin, Marcia, Nannini, Michelle, Friedman, Lori S., Sampath, Deepak
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 1735: Discovery of novel and selective reversible inhibitors of EGFR containing the T790M drug resistance mutation with activity in vitro and in vivo
Schaefer, Gabriele, Hanan, Emily J., Chan, Emily, Shao, Lily, Chen, Yuan, Knight, Jamie, Yauch, Robert L., Schmidt, Stephen, Sideris, Steven, Malek, Shiva, Heffron, Timothy P.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE
BRAUN MARIE GABRIELLE, ELLIOTT RICHARD, MACLEOD CALUM, STABEN STEVEN T, HANAN EMILY, HEALD ROBERT ANDREW
Year of Publication 28.08.2019
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Year of Publication 28.08.2019
Patent
벤즈옥사제핀 옥사졸리디논 화합물 및 사용 방법
BRAUN MARIE GABRIELLE, ELLIOTT RICHARD, MACLEOD CALUM, STABEN STEVEN T, HANAN EMILY, HEALD ROBERT ANDREW
Year of Publication 17.01.2018
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Year of Publication 17.01.2018
Patent
거대환형 광범위 항생제
KOEHLER MICHAEL F. T, ROBERTS TUCKER CURRAN, BLENCH TOBY, PARASELLI PRASUNA, SCHWARZ JACOB BRADLEY, HANAN EMILY J, WINSHIP PAUL COLIN MICHAEL, LY CUONG Q, HU HUIYONG, CHEN YONGSHENG, YU ZHIYONG, HIGUCHI ROBERT I, CRAWFORD JAMES JOHN, SMITH PETER ANDREW, MCCLEOD CALUM
Year of Publication 13.11.2019
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Year of Publication 13.11.2019
Patent
마크로시클릭 광범위 항생제
KOEHLER MICHAEL F. T, HANAN EMILY J, ROBERTS TUCKER CURRAN, CHEN YONGSHENG, LY CUONG Q, HU HUIYONG, YU ZHIYONG, PARASELLI PRASUNA, SCHWARZ JACOB BRADLEY, HIGUCHI ROBERT I, CRAWFORD JAMES JOHN, SMITH PETER ANDREW
Year of Publication 11.10.2018
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Year of Publication 11.10.2018
Patent
PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS
MAGNUSON STEVEN R, LYSSIKATOS JOSEPH P, MENDONCA ROHAN, GIBBONS PAUL, HANAN EMILY, ZHU BING YAN, PASTOR RICHARD, ZAK MARK E, RAWSON THOMAS E, SIU MICHAEL, ZHOU AIHE, LIU WENDY
Year of Publication 04.10.2018
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Year of Publication 04.10.2018
Patent
A facile reduction of 2-aminopyrimidines with triethylsilane and trifluoroacetic acid
Baskaran, Subramanian, Hanan, Emily, Byun, Daniel, Shen, Wang
Published in Tetrahedron letters (01.03.2004)
Published in Tetrahedron letters (01.03.2004)
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Journal Article
PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS
MAGNUSON STEVEN R, LYSSIKATOS JOSEPH P, MENDONCA ROHAN, GIBBONS PAUL, HANAN EMILY, ZHU BING YAN, PASTOR RICHARD, ZAK MARK E, RAWSON THOMAS E, SIU MICHAEL, ZHOU AIHE, LIU WENDY
Year of Publication 25.05.2017
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Year of Publication 25.05.2017
Patent
SUBSTITUTED 6,6-FUSED NITROGENOUS HETEROCYCLIC COMPOUNDS AND USES THEREOF
PURKEY HANS EDWARD, LYSSIKATOS JOSEPH P, GAZZARD LEWIS J, HANAN EMILY, KINTZ SAMUEL
Year of Publication 27.11.2013
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Year of Publication 27.11.2013
Patent
Abstract A20: Development and validation of a novel acute myeloid leukemia xenograft model that is dependent on the JAK2V617F mutation for growth in vivo
Lee, Leslie, Hanan, Emily, Zhou, Aihe, Rawson, Thomas, Li, Ji, Kholi, Pawan Bir, Barrett, Kathy, Chang, Christine, Chen, Jacob, Ubhayakar, Savita, Siu, Mike, Kenny, Jane, Blair, Wade, Ghilardi, Nico, Sampath, Deepak
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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